Speed of sound in normal and degenerated bovine articular cartilage

Töyräs, Juha; Laasanen, Mikko S.; Saarakkala, Simo; Lammi, Mikko J.; Rieppo, Jarno; Kurkijärvi, Jatta; Lappalainen, Reijo; Jurvelin, Jukka S.

doi:10.1016/s0301-5629(02)00708-1

Cited by 106 publications

(46 citation statements)

References 40 publications

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“…Previous research work reported a variation of speed of sound between different measurement sites and degenerative states. 41,56,65 The speed of sound is slightly lower in OA cartilage than in normal cartilage 65 and digestion of PGs may reduce the speed of sound in cartilage as well. 63 As reported by Toyras et al, 65 with considering the variable speed of sound, the use of a predefined speed of sound, 1636 m/s, 56 may induce an error of (mean ± SD) 2.9 ± 1.9% for the measurement of cartilage thickness, which would further induce an error of 0.9 ± 0.6% for the stiffness ratio.…”

Section: Discussionmentioning

confidence: 99%

Noncontact Evaluation of Articular Cartilage Degeneration Using a Novel Ultrasound Water Jet Indentation System

Zheng

Huang

et al. 2008

Ann Biomed Eng

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Assessment of articular cartilage degeneration induced by degenerative diseases using quantitative ultrasound method is promising but challenging. Currently, in literature, proposed methods have limited diagnostic abilities, and some quantitative ultrasound cartilage evaluation results are inconsistent or hard to compare with each other. Thus it is desirable to find a parameter which is easier to compare and can sensitively reflect changes due to cartilage degeneration. In the present study, a new parameter "averaged magnitude ratio" (AMR) was defined as an indicator to detect articular cartilage degeneration. In vitro experiments were conducted on 12 cartilage-bone samples from porcine knee joints. Six of the samples were digested using 0.25% trypsin solution. Ultrasound V (z, t) signal was collected from the samples using a broadband ultrasound transducer with center frequency of 15MHz. Integrated reflection coefficient (IRC), apparent integrated backscattering coefficient (AIB) and AMR were computed from ultrasound signal. Young's modulus of the samples was measured using atomic force microscopy (AFM). With Mann-Whitney U test, statistically significant decrease in IRC and increase in AMR were observed after digestion. With Pearson's correlation analysis, Young's modulus was significantly correlated with AMR, IRC, and AIB. Our results demonstrate that AMR is sensitive to enzymatically induced cartilage changes. AMR is easier to compute, needs no reference material and can achieve equivalent or even better performance than IRC and AIB in detecting cartilage degeneration.

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Section: Discussionmentioning

confidence: 99%

Noncontact Evaluation of Articular Cartilage Degeneration Using a Novel Ultrasound Water Jet Indentation System

Zheng

Huang

et al. 2008

Ann Biomed Eng

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“…The acoustic and mechanical properties of the sample disks were determined simultaneously with a custommade apparatus (Laasanen et al 2002;Töyräs et al 2003) (Fig. 1).…”

Section: Mechano-acoustic Testingmentioning

confidence: 99%

Ultrasound Speed in Articular Cartilage Under Mechanical Compression

Nieminen

Julkunen

Töyräs

et al. 2007

Ultrasound in Medicine & Biology

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“…Myers et al (20) and Töyräs et al (21) measured the thickness of articular cartilage in advance and then measured the sound velocity from the times of flight of ultrasonic waves from the articular cartilage surface and subchondral bone. They observed a significant decrease in sound velocity-from about 1 650 m/s in intact cartilage to about 1 550 m/s in degenerated articular cartilage.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, compared with cartilage degeneration, the rates of change for these measured values are as small as 10% or less (20), (21) . Contrary, in evaluation using the signal intensity, the articular cartilage thickness or other information is not necessary and a small device with one transducer is sufficient.…”

Section: Discussionmentioning

confidence: 99%

Non-Contact Evaluation for Articular Cartilage Using Ultrasound

Mori

Nakagawa

Kuroki

et al. 2006

JSME Int. J., Ser. A

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In orthopedic field, various new treatments of articular cartilage defect, for example autogenous osteochondral grafts, have been developed. With the spread of these treatments, orthopedists began to focus on the mechanical properties of recovered articular cartilage. The quantitative evaluation of articular cartilage before and after these treatments gives orthopedists the important information to improve these treatments and develop new treatments. We have been investigating the non-contact ultrasonic evaluation for articular cartilage under arthroscopy. In this paper, it was hypothesized that the ultrasonic evaluation depended on the collagen fiber in cartilage. The enzymatically degradation of collagen fiber in cartilage surface was performed. The effect of the degradation on sound velocity, attenuation coefficient and signal intensity, which is the index of cartilage stiffness calculated from the proposed method, was measured. The numerical analysis was performed to clear the relation between the cartilage character and ultrasonic parameters. Experimental and numerical results suggest that the present method can be expanded the sensitive evaluation for cartilage disease in clinical field.

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Speed of sound in normal and degenerated bovine articular cartilage

Cited by 106 publications

References 40 publications

Noncontact Evaluation of Articular Cartilage Degeneration Using a Novel Ultrasound Water Jet Indentation System

Noncontact Evaluation of Articular Cartilage Degeneration Using a Novel Ultrasound Water Jet Indentation System

Ultrasound Speed in Articular Cartilage Under Mechanical Compression

Non-Contact Evaluation for Articular Cartilage Using Ultrasound

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