Speed and power-related gene polymorphisms associated with playing position in elite soccer players

Petr, Michal; Thiel, Dan; Kvapilová, Kateřina; Brož, Petr; Malý, Tomáš; Zahálka, František; Vostatková, Pavlína; Wilk, Michał; Chycki, Jakub; Šťastný, Petr

doi:10.5114/biolsport.2022.105333

Cited by 17 publications

(12 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have found that players with the XX genotype have certain susceptibility to developing non-contact musculoskeletal injury [ 18 , 19 ] and need more recovery time to return to play after this type of injury [ 20 ]. Probably, the lower values of quadriceps and hamstrings isokinetic strength in XX than RR players constitute a disadvantage to prevent muscle injuries in football [ 21 ], as most of the non-contact muscle injuries in football are located at the thigh, with a particularly high incidence in hamstring muscle [ 22 ]. However, these findings have been found in samples of male professional football players, while the influence of the ACTN3 XX genotype on the probability of non-contact muscle injury—or any other type of injury— has not been tested in professional women football players.…”

Section: Introductionmentioning

confidence: 99%

Association of the ACTN3 rs1815739 Polymorphism with Physical Performance and Injury Incidence in Professional Women Football Players

Coso

Rodas

Buil³

et al. 2022

Genes

View full text Add to dashboard Cite

The p.R577X polymorphism (rs1815739) in the ACTN3 gene causes individuals with the XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries, in comparison with RR and RX athletes who produce a functional α-actinin-3 in their fast-twitch fibers. This investigation aimed to determine the influence of the ACTN3 R577X polymorphism on physical performance and injury incidence of players competing in the women’s Spanish first division of football (soccer). Using a cross-sectional experiment, football-specific performance and epidemiology of non-contact football-related injuries were recorded in a group of 191 professional football players. ACTN3 R577X genotype was obtained for each player using genomic DNA samples obtained through buccal swabs. A battery of physical tests, including a countermovement jump, a 20 m sprint test, the sit-and-reach test and ankle dorsiflexion, were performed during the preseason. Injury incidence and characteristics of non-contact injuries were obtained according to the International Olympic Committee (IOC) statement for one season. From the study sample, 28.3% of players had the RR genotype, 52.9% had the RX genotype, and 18.8% had the XX genotype. Differences among genotypes were identified with one-way analysis of variance (numerical variables) or chi-square tests (categorical variables). Jump height (p = 0.087), sprint time (p = 0.210), sit-and-reach distance (p = 0.361), and dorsiflexion in the right (p = 0.550) and left ankle (p = 0.992) were similar in RR, RX, and XX football players. A total of 356 non-contact injuries were recorded in 144 football players while the remaining 47 did not sustain any non-contact injuries during the season. Injury incidence was 10.4 ± 8.6, 8.2 ± 5.7, and 8.9 ± 5.3 injuries per/1000 h of football exposure, without differences among genotypes (p = 0.222). Injury rates during training (from 3.6 ± 3.7 to 4.8 ± 2.1 injuries per/1000 h of training exposure, p = 0.100) and match (from 47.8 ± 9.5 to 54.1 ± 6.3 injuries per/1000 h of match exposure, p = 0.209) were also similar in RR, RX, and XX football players. The ACTN3 genotype did not affect the mode of onset, the time needed to return to play, the type of injury, or the distribution of body locations of the injuries. In summary, women football players with different genotypes of the p.R577X ACTN3 polymorphism had similar values of football-specific performance and injury incidence. From a practical perspective, the ACTN3 genotyping may not be useful to predict performance or injury incidence in professional women football players.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of the ACTN3 rs1815739 Polymorphism with Physical Performance and Injury Incidence in Professional Women Football Players

Coso

Rodas

Buil³

et al. 2022

Genes

View full text Add to dashboard Cite

show abstract

“…How ever, regarding the above points and the limited number of soccer players (n = 43) of mixed geographic ancestry (and the lack of con trol group) in the study by Clos et al [76], it is unlikely that this study had sufficient statistical power to detect an association of genotype with playing position. Although a recent study by Petr et al [77] did include a control group (n = 107) and a larger cohort of soccer players (n = 99), the latter sample size was still relatively modest, considering this needed to be segregated into much small er groups for playing position and genetic analyses.…”

Section: Phenotype: Athlete Statusmentioning

confidence: 99%

The Genetic Association with Athlete Status, Physical Performance, and Injury Risk in Soccer

et al. 2023

View full text Add to dashboard Cite

The aim of this review was to critically appraise the literature concerning the genetic association with player status, physical performance and injury risk in soccer. The objectives were to provide guidance on which genetic markers could potentially be used as part of future practice in soccer; and to provide direction for future research in this area. The most compelling evidence identified six genetic polymorphisms to be associated with soccer athlete status (ACE I/D; ACTN3 rs1815739; AGT rs699; MCT1 rs1049434; NOS3 rs2070744; PPARA rs4253778), six with physical performance (ACTN3 rs1815739; AMPD1 rs17602729; BDNF rs6265; COL2A1 rs2070739; COL5A1 rs12722; NOS3 rs2070744), and seven with injury risk (ACTN3 rs1815739; CCL2 rs2857656; COL1A1 rs1800012; COL5A1 rs12722; EMILIN1 rs2289360; IL6 rs1800795; MMP3 rs679620). As well as replication by independent groups, large-scale genome-wide association studies are required to identify new genetic markers. Future research should also investigate the physiological mechanisms associating these polymorphisms with specific phenotypes. Further, researchers should investigate the above associations in female and non-Caucasian soccer players, as almost all published studies have recruited male participants of European ancestry. Only after robust, independently replicated genetic data have been generated, can genetic testing be considered an additional tool to potentially inform future practice in soccer.

show abstract

“…Clos et al, (2021) reported that the RR genotype and the R allele was the most common in wide midfielders, wingers and forwards. Petr et al (2022) reported that the ACTN3 RR genotype in defenders was associated with higher lower limb strength than either the RX or XX genotypes. Previous studies have focused on the association between ACTN3 genotypes and athletic performance in professional players, and the differences in the distribution of ACTN3 genotypes among players at different positions.…”

Section: Introductionmentioning

confidence: 99%

Association between ACTN3 R577x and the physical performance of Chinese 13 to 15-year-old elite and sub-elite football players at different positions

et al. 2023

View full text Add to dashboard Cite

The purpose of this study was to investigate the prevalence of ACTN3 polymorphisms in Chinese elite and sub-elite football players aged 13–15 years at different positions. Specifically we explored whether ACTN3 genotypes were linked with athletic performance of elite and sub-elite players at different positions. The RR genotype frequency of elite defenders (p = 0.018) and midfielders (p = 0.008) was significantly higher than that of sub-elite XX genotype in elite players. Furthermore, the R allele frequency of elite defenders (p = 0.003) and midfielders (p = 0.008) was significantly higher than that of sub-elite players. In all subjects, RR players performed faster and exhibited more explosive power than RX or XX players. RR, RX and XX elite players’ 20 m/30 m sprint, 5 × 25-m repeated sprint ability (5 × 25 m RSA), and standing long jump were stronger than sub-elite players, but there was no significant different in aerobic endurance between elite and sub-elite players at different positions. In conclusion, there were significant differences in ACTN3 genotypes and alleles between elite and sub-elite players at different positions, and the RR genotype was significantly associated with power-related athletic performance in Chinese youth football players.

show abstract

Speed and power-related gene polymorphisms associated with playing position in elite soccer players

Cited by 17 publications

References 58 publications

Association of the ACTN3 rs1815739 Polymorphism with Physical Performance and Injury Incidence in Professional Women Football Players

Association of the ACTN3 rs1815739 Polymorphism with Physical Performance and Injury Incidence in Professional Women Football Players

The Genetic Association with Athlete Status, Physical Performance, and Injury Risk in Soccer

Association between ACTN3 R577x and the physical performance of Chinese 13 to 15-year-old elite and sub-elite football players at different positions

Contact Info

Product

Resources

About