The Genetic Association with Athlete Status, Physical Performance,
                    and Injury Risk in Soccer

Murtagh, Conall F.; Hall, Elliott; Brownlee, Thomas E.; Drust, Barry; Williams, Alun G.; Erskine, Robert M.

doi:10.1055/a-2103-0165

Cited by 4 publications

(1 citation statement)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, we have not provided information regarding genetic markers associated with team (game) and combat sports, flexibility, coordination, personality, cognitive abilities, muscle fibre composition, skeletal muscle hypertrophy, injuries, and responses to training/supplements. These markers are well described elsewhere [ 4 , 24 , 26 , 28 , 37 , 61 , 74 , 79 , 115 , 116 , 117 , 333 , 334 ]. Second, we have not described all studies in detail (ethnicity, specific sporting disciplines, sample size, p -values etc.)…”

Section: Discussionmentioning

confidence: 99%

Genes and Athletic Performance: The 2023 Update

Semenova

Hall

Ahmetov

2023

Genes

Self Cite

View full text Add to dashboard Cite

Phenotypes of athletic performance and exercise capacity are complex traits influenced by both genetic and environmental factors. This update on the panel of genetic markers (DNA polymorphisms) associated with athlete status summarises recent advances in sports genomics research, including findings from candidate gene and genome-wide association (GWAS) studies, meta-analyses, and findings involving larger-scale initiatives such as the UK Biobank. As of the end of May 2023, a total of 251 DNA polymorphisms have been associated with athlete status, of which 128 genetic markers were positively associated with athlete status in at least two studies (41 endurance-related, 45 power-related, and 42 strength-related). The most promising genetic markers include the AMPD1 rs17602729 C, CDKN1A rs236448 A, HFE rs1799945 G, MYBPC3 rs1052373 G, NFIA-AS2 rs1572312 C, PPARA rs4253778 G, and PPARGC1A rs8192678 G alleles for endurance; ACTN3 rs1815739 C, AMPD1 rs17602729 C, CDKN1A rs236448 C, CPNE5 rs3213537 G, GALNTL6 rs558129 T, IGF2 rs680 G, IGSF3 rs699785 A, NOS3 rs2070744 T, and TRHR rs7832552 T alleles for power; and ACTN3 rs1815739 C, AR ≥21 CAG repeats, LRPPRC rs10186876 A, MMS22L rs9320823 T, PHACTR1 rs6905419 C, and PPARG rs1801282 G alleles for strength. It should be appreciated, however, that elite performance still cannot be predicted well using only genetic testing.

show abstract

Section: Discussionmentioning

confidence: 99%

Genes and Athletic Performance: The 2023 Update

Semenova

Hall

Ahmetov

2023

Genes

Self Cite

View full text Add to dashboard Cite

show abstract

Review über die Bedeutung der Gene im Fußball

2024

Sportverletz Sportschaden

View full text Add to dashboard Cite

Harte Arbeit allein reicht nicht aus, um zum Profi-Fußballer heranzureifen. Seit Jahren werden genetische Einflüsse diskutiert und teilweise bestätigt. Die wissenschaftliche Grundlage ist laut Murtagh et al. bislang aber nicht ausreichend robust. Studien konzentrierten sich auf Kandidatengene, hatten geringe Fallzahlen und untersuchten teilweise mehrere Sportarten gemeinsam. Der Review gibt einen Datenüberblick und fasst zusammen, welche genetischen Polymorphismen mit dem Athletenstatus, der körperlichen Performanz und dem Verletzungsrisiko assoziiert waren.

show abstract

Influence of ACTN3 R577X Polymorphism on Blood Creatine Kinase Levels Relative to Number of Sprints in Brazilian Professional Soccer Players

de Almeida,

Zempo,

Saito

et al. 2024

Genes

View full text Add to dashboard Cite

This study sought to assess how post-game creatine kinase (CK) levels correlate with the number of sprints and the impact of the ACTN3 polymorphism on this response. This research constituted a descriptive/observational, retrospective cross-sectional study. DNA was extracted from blood samples for ACTN3 polymorphism genotyping. CK was measured 48 h after official matches, and the number of sprints (>19 km/h) was tracked using Global Positioning System (GPS) technology. The main cohort included 23 professional soccer players from the top tier of the Brazilian Championship. We analyzed 115 GPS + CK data sets. The replication cohort comprised 18 professional soccer players from the First Division of the Championship, had the same methodology applied, and featured a total of 90 GPS (sprints > 25.2 km/h) + CK data sets. For the main cohort, a significant positive correlation was seen between the number of sprints and the CK levels (p = 0.009). Athletes with the ACTN3 RR genotype had higher CK levels as more sprints were performed during the match (p = 0.017). However, the relationship was not found for X allele carriers (p > 0.05). For the replication cohort, there was a near-significant correlation between CK levels and the number of sprints (p = 0.05), and RR individuals showed a significant association (p = 0.01), whereas X allele carriers did not (p = 0.06). A greater number of sprints during matches is linked to higher CK levels, primarily among players with the ACTN3 RR genotype, which is potentially due to an increased presence of type II muscle fibers. These findings were replicated for both cohorts of elite Brazilian soccer players, emphasizing the importance of genetic factors in injury prevention.

show abstract

The Genetic Association with Athlete Status, Physical Performance, and Injury Risk in Soccer

Cited by 4 publications

References 195 publications

Genes and Athletic Performance: The 2023 Update

Genes and Athletic Performance: The 2023 Update

Review über die Bedeutung der Gene im Fußball

Influence of ACTN3 R577X Polymorphism on Blood Creatine Kinase Levels Relative to Number of Sprints in Brazilian Professional Soccer Players

Contact Info

Product

Resources

About