Speech and the unspeakable in the “place” of the unconscious

Scott, Charles E.

doi:10.1007/bf02633644

Cited by 5 publications

(9 citation statements)

References 1 publication

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“…Reference materials were Cu 2 O (cuprite), CuO (tenorite), PbO (litharge), PbO 2 (plattnerite), PbSO 4 (anglesite), PbCO 3 (cerussite), PbCl 2 (cotunnite), all Merck reagents, accompanied by 2PbCO 3 ⋅ Pb(OH) 2 , (synthetic hydrocerussite, Sigma‐Aldrich) and CuCl (De Haën). Azurite (K10200) and malachite (K10300) were Kremer pigments, whereas brochantite and different copper trihydroxychlorides (atacamite, clinoatacamite) were prepared by means of recommended procedures 44.…”

Section: Methodsmentioning

confidence: 99%

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

et al. 2014

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Water is ubiquitously present in any biological system and has therefore to be regarded as an additional binding partner in the protein-ligand binding process. Upon complex formation, a new solvent-exposed surface is generated and water molecules from the first solvation layer will arrange around this newly formed surface. So far, the influence of such water arrangements on the ligand binding properties is unknown. In this study, the binding modes of nine congeneric phosphonamidate-type inhibitors with systematically varied, size-increasing hydrophobic P2 ' substituents (from methyl to phenylethyl) addressing the hydrophobic, solvent-exposed S2 ' pocket of thermolysin were analyzed by high-resolution crystal structures and correlated with their thermodynamic binding profiles as measured by isothermal titration calorimetry. Overall, ΔΔG spreads over 7.0 kJ mol(-1) , ΔΔH varies by 15.8 kJ mol(-1) , and -TΔΔS by 12.1 kJ mol(-1) . Throughout the series, these changes correlate remarkably well with the geometric differences of water molecules arranged adjacent to the P2 ' substituents. Ligands with medium-sized P2 ' substituents exhibit highest affinities, presumably because of their optimal solvation patterns around these complexes. The addition, removal, or rearrangement of even a single methyl group can result in a strong modulation of the adjacent water network pattern shifting from enthalpy to entropy-driven binding. In conclusion, the quality of a water network assembled around a protein-ligand complex influences the enthalpy/entropy signature and can even modulate affinity to a surprising extent.

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Section: Methodsmentioning

confidence: 99%

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

et al. 2014

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“…[12][13][14][15][16] However, more detailed investigation of works of art revealed that a huge variety of Cu salts were also used as pigments (sulphates, phosphates, chlorides). [5,[17][18][19][20][21][22][23] This fact implies that the identification of Cu in a green area cannot be straightforwardly interpreted as related to the presence of the traditional pigments malachite or verdigris, but a deeper investigation is required. [5] For example, the simulta-neous detection of Cu and Cl could be related, at the same time, to the natural mineral atacamite or to the synthetic copper phtalocyanine green, which is a modern synthetic pigment.…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopy of green minerals and reaction products with an application in Cultural Heritage research

Coccato

Bersani

Coudray

et al. 2016

J Raman Spectroscopy

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Raman spectroscopy is a powerful technique for the characterization of materials and is of valuable use in archaeometrical research in general. Green compounds of natural or synthetic origin are found in many research areas, ranging from mineralogy, to pigment identification, to corrosion studies. However, a detailed and comprehensive database of spectra and references is still missing in the literature. This paper provides both, a literature review and downloadable Raman spectra of reference products, to the researcher dealing with green materials in cultural heritage. Moreover, it tackles nomenclature issues. The collected spectra are discussed in relation to the preliminary/commercial identification of the material itself and to the published data. Practical aspects regarding the laser wavelength selection are also discussed with regards to the comparison to published reference spectra. The range of studied green materials is wide and encompasses Cu containing compounds (natural and synthetic, more or less known as pigments or degradation products, including polymorphs of the same formula), Fe based (green earths and synthetic organic pigments), modern Cr and Co green pigments. This approach is illustrated by analysing a cross section of a green zone of the Early Netherlandish panel painting ‘Ghent Altarpiece’ by the Van Eyck brothers. Copyright © 2016 John Wiley & Sons, Ltd.

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“…It shows that tin oxide will form as a main product in corroded bronze artefacts in soil and may be present in the Sn‐rich phases in Haft Tappeh objects. Nevertheless, presence of a high amount of soluble Cl and the negative Gibbs free energy of formation (∆G f ) for copper chloride compounds have led to formation of atacamite and paratacamite as the significant corrosion products in Haft Tappeh copper alloys. On the other hand, results of previous works on Haft Tappeh and the presence of cassiterite in one sample in this research prove that Sn‐rich phases are available in corrosion layers especially in white‐grey central phase in some corroded samples .…”

Section: Resultsmentioning

confidence: 99%

“…During burial or after excavation, nantokite will form atacamite or paratacamite (copper trihydroxychlorides) in the presence of moisture and oxygen. This so‐called phenomenon ‘bronze disease’ is a cyclic reaction not needing the further introduction of oxygen or chlorine ions and will continue until all metal/alloy are transformed into copper corrosion products . The first product of the reaction is nantokite (CuCl) .…”

Section: Introductionmentioning

confidence: 99%

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Multianalytical study of corrosion layers in some archaeological copper alloy artefacts

Oudbashi

2015

Surface & Interface Analysis

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Corrosion layers in some copper and bronze archaeological objects from Haft Tappeh archaeological site, southwest Iran, were studied. For this purpose, optical microscopy, scanning electron microscopy with energy dispersive X‐ray microanalysis, micro‐Raman spectroscopy and X‐ray diffraction methods were applied to observe corrosion stratigraphy and their characteristics as well as identification of chemical composition and phase determination of different corrosion layers. Based on optical and electron microscopy, three different corrosion strata were identified in cross section of different metallic objects including various red, green, white‐grey powdery and dark internal compact layers. Scanning electron microscopy with energy dispersive X‐ray microanalysis on different corrosion layers revealed that Cu, Sn and Cl are the main elements in the chemical composition of different layers. Tin‐rich phases were detected in white‐grey and dark layers that may be formed because of the internal oxidation of tin as well as the decuprification (selective dissolution of copper) phenomena occurring during long‐term burial period in the soil. Also, the XRD and micro‐Raman spectroscopy results proved that the main corrosion products are nantokite (CuCl), copper trihydroxychlorides and copper oxides. The combination of these analytical methods allows us to explore the surface and internal corrosion layers of the archaeological copper and bronze samples, and major interest is on studying their chemistry, microstructural properties and corrosion stratigraphy. Copyright © 2015 John Wiley & Sons, Ltd.

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Speech and the unspeakable in the “place” of the unconscious

Cited by 5 publications

References 1 publication

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

Raman spectroscopy of green minerals and reaction products with an application in Cultural Heritage research

Multianalytical study of corrosion layers in some archaeological copper alloy artefacts

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