Spectrum of Nonpuerperal Galactorrhea: Report of Two Cases Evolving Through the Various Syndromes¹

Cushing' Disease: Management by Transsphenoidal Pituitary Microsurgery*

“…Complete bilateral adrenalectomy has been associated with subsequent emergence of an expanding ACTH-secreting pituitary tumor in some patients (27) and also necessarily leaves the patient dependent upon exogenous glucocorticoid and mineralocorticoid therapy. A transfrontal intracranial surgical approach was taken in some patients who had demonstrated obvious abnormalities of the sella turcica by standard radiographic techniques (28)(29)(30)(31)(32)(33)(34). The transfrontal approach allowed only limited visualization of the adenohypophysis, and selective tumor removal was virtually impossible.…”

SUCCESSFUL TREATMENT OF GALACTORRHOEA AND AMENORRHOEA AND SUBSEQUENT RESTORATION OF OVARIAN FUNCTION BY a NEW ERGOT ALKALOID 2‐BROM‐α‐ERGOCRYPTINE

“…The primary cause of the development of these syndromes is not yet known. Patients have been reported evolving through the various syndromes with the additional manifestation at a later stage of Cushing's disease due to chromophobe adenomas of the pituitary gland (Young et al, 1967;Mahesh et al, 1969).…”

Plasma Prolactin Activity in Inappropriate Lactation

“…These are not distinct entities, however, since patients may progress from one syndrome to another and finally may develop acromegaly or Cushing's disease (Young et al, 1967;Mahesh et al, 1969). We have shown significant plasma prolactin activity in four out of six patients with the galactorrhoea-amenorrhoea-pituitary tumour syndrome and in half of the other patients with inappropriate lactation.…”