Spectrum of Non Neoplastic Skin Diseases: A Histopathology Based Clinicopathological Correlation Study at a Tertiary Health Care Centre

Abstract

Introduction: Skin biopsy probably is the most important ancillary aid to confirm clinical diagnosis. The interpretation of many skin biopsies requires the identification and integration of two different morphological features -the tissue reaction pattern and the pattern of inflammation. Aim: To correlate histopathological diagnosis with clinical diagnosis in various non neoplastic skin lesions. Materials and Methods: The present study was a prospective and observational type of study. A total number of 197 participants were included after satisfying the eligibility criteria with due permission from Department of Dermatology. Only those patients who had given valid informed consent were included in the study. Results: Out of 197 biopsies studied, histopathological diagnosis in 167 biopsies (84.8%) was consistent with clinical diagnosis, while in 30 biopsies (15.2%) histopathological diagnosis was not consistent with clinical diagnosis. Conclusion: Out of 197 cases (M=111, F=86) biopsies studied, histopathological diagnosis was consistent with clinical diagnosis in 167 biopsies (84.8%), while in 30 biopsies (15.2%) the histopathological diagnosis was not consistent with clinical diagnosis. The skin biopsy remains the gold standard for diagnosis which can be supported with other techniques to confirm the diagnosis. This emphasizes the significance of histopathology in diagnosing non neoplastic skin disorders.

Histomorphological analysis and clinical correlation of neoplastic and non neoplastic skin lesions: a study in a tertiary care centre of Western Uttar Pradesh, India

“…In another case, a diagnosis of lichen planus pigmentosus was given clinically diagnosed as eruptive lichen planus. In about 25% of the cases, the clinical 5,7,9 In this study maximum clinical lesions presented as plaque like lesions, similar to finding by study of Bajaj et al 7 In this study, with respect to duration of illnesses, 39.16% of cases presented with a duration of 1-6 months in agreement with the study of Vaghela et al where also, most cases (44%) presented within 0-6 months. 10 In this study authors observed that maximum number of cases i.e.…”

“…5 Vesicobullous lesions were less common in our study with 5 (4.16%) reported cases. Leprosy was also the most common lesion in studies by Bajaj et al, Narang et al, D Costa et al(Study in pediatric population) and Rohit et al 2,7,9 In another study also conducted in western UP over a 4 year period by Grover et al, inflammatory diseases (Bullous lesions and Psoriasis) was the most common group (73.47% cases) while infectious diseases was the second most common group (22.99% cases), leprosy being the most common. 13 In this study, leprosy comprised 87.7% of the infectious lesions, this percentage was 78.26% in study by Rohit et al 2 In, a study of Non neoplastic skin lesions by Vaghela et al in Gujarat, most common lesion was observed to be inflammatory disease of the dermis and epidermis (51%), while infectious diseases of skin (25%) was the second most common.…”

“…This is similar to a study by Bajaj et al where they found clinicopathologic consistency to be 75.34%. 7 for all the skin lesions and 84.8% for the non neoplastic lesions. Aslan et al reported 76.8% cases having positive histopathologic correlation.…”