Spectrum of hemoglobinopathies with hematological and biochemical profile: A five year experience from a tertiary care hospital

Mansoor, Neelum; Meraj, Fatima; Shaikh, Ameerah; Jabbar, Naeem

doi:10.12669/pjms.38.8.5935

Cited by 3 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This component derived from the first phase of glycation of haemoglobin HbA, which is a rapid, reversible and dependent phase of the plasma glucose concentration (10). A falsely low HbA1c concentration can result from several conditions, including prolonged stay at high altitude, pregnancy, bleeding, blood transfusion, erythropoietin management, iron supplementation, haemolytic anaemia, chronic kidney failure, liver cirrhosis, alcoholism, sickle cell anaemia and spherocytosis (3,8,(10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Undetectable high-performance liquid chromatography haemoglobin A1c on variant haemoglobin E phenotype

Marpaung,

Sadriani

2023

Biochem. med. (Online)

View full text Add to dashboard Cite

The gold standard for long-term monitoring of diabetic patients is glycated haemoglobin (HbA1c), which is routinely tested for glycaemic control. Furthermore, the National glycohemoglobin standardization program (NGSP) has designated high-performance liquid chromatography (HPLC) as the reference method for HbA1c measurement. A woman from the Sumba tribe, Indonesia, aged 52, visited the Internal Medicine Clinic for a routine check-up. She had been taking diabetic and hypertension medicines on a regular basis for over 10 years. The HPLC procedure yielded “no result” for the patient’s HbA1c assessment and there was no peak on the HPLC graphic. However, there was a discrepancy between the data history of HbA1c measured by turbidimetric method (average of 51 mmol/mol, reference range < 48 mmol/mol), fasting blood glucose (average of 7.7 mmol/L, reference range < 7.0 mmol/L) and 2-hour plasma glucose (average of 13 mmol/L, reference range < 11.1 mmol/L). Glycated albumin was 3.1 mmol/L (reference range 1.8-2.4 mmol/L). Haemoglobin electrophoresis identified homozygote haemoglobinopathy E (HbE). Patients with haemoglobin variants are proposed to utilize glycated albumin.

show abstract

Section: Discussionmentioning

confidence: 99%

Undetectable high-performance liquid chromatography haemoglobin A1c on variant haemoglobin E phenotype

Marpaung,

Sadriani

2023

Biochem. med. (Online)

View full text Add to dashboard Cite

show abstract

“…Thyroid dysfunction is very commonly encountered in clinical practice. The prevalence of thyroid dysfunction is approximately 5–10% during a lifetime [3]. Management of thyroid disorders depends on accurate clinical assessment and appropriate investigations [4].…”

Section: Introductionmentioning

confidence: 99%

The utility of technetium-99m pertechnetate thyroid scintigraphy assessing thyroid/salivary ratio as an alternative to thyroid uptake percentage in evaluation of thyroid function, with establishing normal reference values of both parameters: single Egyptian center study

Abdelhamed

Soliman

Mahmoud

et al. 2022

Nuclear Medicine Communications

View full text Add to dashboard Cite

Background/Objective Management of thyroid disorders depends on accurate clinical assessment, appropriate investigations and radionuclide imaging, which plays an established important role either qualitatively or quantitatively. The aim of this study was to assess the utility of the thyroid/salivary ratio (TSR) as an alternative to technetium-99m (Tc99m) pertechnetate thyroid uptake (TcU) percentage in the evaluation of thyroid function and in the same time to establish reference range for the thyroid uptake of Tc99m-pertechnetate and TSR among Egyptian populations. Patients and methods This retrospective study enrolled 270 patients, out of which 250 with different thyroid disorders and 20 without thyroid diseases, as a control group who all underwent full clinical examination, thyroid function tests and Tc99m pertechnetate thyroid scintigraphy. The TcU percentage and TSR were calculated and then correlated to the thyroid hormonal profile. Results The normal reference ranges of TcU and TSR were 0.75–3.5% and 1.25–4.8%, respectively. The sensitivity and specificity of TSR to diagnose hyperthyroidism were slightly lower compared with TcU (84.5 and 92.3% vs. 86.2 and 98.3%, respectively) at TSR cutoff value of more than 4.8 and TcU cutoff value of more than 3.5. Meanwhile, they had comparable sensitivity and specificity to diagnose hypothyroidism (86.0 and 93.3% vs. 86.5 and 94.5%) at cutoff values <0.75 and <1.25, respectively. Conclusion The current study established a reference range for TcU and TSR in our institution. TSR is comparable to TcU in the evaluation of thyroid function among hyper-and hypothyroid patients and TSR can be used in doubtful cases of mal-thyroid function for confirmation of the diagnosis.

show abstract

Detection of HbD Punjab Trait in Saurashtra Region of Gujarat by HPLC Method

Dholariya,

Parchwani,

Sonagra

et al. 2023

Ind J Clin Biochem

View full text Add to dashboard Cite

Spectrum of hemoglobinopathies with hematological and biochemical profile: A five year experience from a tertiary care hospital

Cited by 3 publications

References 22 publications

Undetectable high-performance liquid chromatography haemoglobin A1c on variant haemoglobin E phenotype

Undetectable high-performance liquid chromatography haemoglobin A1c on variant haemoglobin E phenotype

The utility of technetium-99m pertechnetate thyroid scintigraphy assessing thyroid/salivary ratio as an alternative to thyroid uptake percentage in evaluation of thyroid function, with establishing normal reference values of both parameters: single Egyptian center study

Detection of HbD Punjab Trait in Saurashtra Region of Gujarat by HPLC Method

Contact Info

Product

Resources

About