Spectrum of Haemoglobinopathies in a Suburb of Indore (India): A Two Year Study

Narang, Sanjeev; Singh, Anjali; Nema, Shrikant

doi:10.21088/ijprp.2278.148x.62(pt-ii)17.6

Cited by 2 publications

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“…Other studies show relatively high prevalence of Sickle cell trait like Narang et al 4 and Iqbal et al who have quoted a prevalence of 6% and 10.8% respectively.…”

Section: Sickle Cell Traitmentioning

confidence: 85%

“…In our study 8% cases were positive for Beta thalassemia trait. Narang et al 4 had done a study on 200 patients in Indore and found out 6.5% prevalence, Sachdev et al 5 had done a study on 2600 patients in Haryana and found a prevalence of 8.9% and Iqbal et al 11 had done a study on 518 patients in Davangere and reported a prevalence of 7.72% for Beta thalassemia trait.…”

Section: Beta Thalassemia Traitmentioning

confidence: 99%

“…High index of suspicion in anemic subjects especially between 6-15 years of age is the most important factor for curbing this condition by early detection followed by genetic counselling and prenatal diagnosis in subsequent pregnancies. Larger studies spread over a wide geographical area should also be undertaken 4 .…”

Section: Introductionmentioning

confidence: 99%

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Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Bajaj¹,

Gupta²

2021

mvpjms

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Introduction: Thalassemia and other hemoglobinopathies are the most common routinely encountered congenital anemias in India. Sickle cell anemia is very common, so a study to rule out all the hemoglobinopathies is essential. Aims and Objectives: The present study was conducted to diagnose various hemoglobinopathies among clinically suspected cases., the present study was conducted to diagnose various hemoglobinopathies among clinically suspected cases. Materials and Methods: A total of 212 cases cases were undertaken in this study after they met the inclusion and exclusion criteria. HPLC was performed on the samples received in the Central Clinical Laboratory of Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik, Maharashtra. Results: Out of 212 cases, 42 cases showed positivity for thalassemia or presence of abnormal hemoglobin, with 8% cases of Beta thalassemia trait, 1.88% cases of Beta thalassemia major, 4.7% cases of Sickle cell trait, 4.24% cases of Sickle cell disease and 0.94% cases of Sickle-thalassemia. Conclusions: HPLC is a fast, reliable, and cost-effective method to diagnose any suspected case of hemoglobinopathy.

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“…Other studies show relatively high prevalence of Sickle cell trait like Narang et al 4 and Iqbal et al who have quoted a prevalence of 6% and 10.8% respectively.…”

Section: Sickle Cell Traitmentioning

confidence: 85%

Section: Beta Thalassemia Traitmentioning

confidence: 99%

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Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Bajaj¹,

Gupta²

2021

mvpjms

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Evaluation of Microcytic Hypochromic Anemia by Electrophoresis for Hemoglobinopathies in Young Population

SINGH

Saxena

BIDWAI

et al. 2023

Asian J Pharm Clin Res

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Objectives: Hemoglobinopathies are serious genetic blood disorders requiring lifelong blood transfusions and treatment in its most severe and chronic form. If undiagnosed or untreated, these disorders ultimately lead to death. South Asia especially India, Pakistan, and Bangladesh has high populations of hemoglobinopathies. In India, there are an estimated 100,000 thalassemia majors patients and nearly 3.5 to 4 million carriers of this genetic disorder. Tribal populations in India have a range of 5–40% sickle cell anemia (SCA) sufferers. The aim of the study was to detect hemoglobinopathies by electrophoresis in microcytic hypochromic anemia in young population in the area covered by tertiary care center at Index Medical College and Hospital. Methods: A cross-sectional study was carried out in a hospital in rural area of Indore on young patients (10–30 years age group) who attended outpatient department from June 2018 to March 2020. Total 517 cases of moderate to severe anemia were included in the study. All cases were subjected to a series of hematological investigations, which include complete hemogram, peripheral blood smear, and some standard procedures. Sysmex XS800i fully automated Cell counter was used for complete blood count. It is the 5-part differential instrument. It reports on all the five subpopulations, namely, neutrophils, eosinophils, basophils, monocytes, and lymphocytes. A blood smear is a blood test used to look for abnormalities in blood cells. Results: In the study, out of 517 cases 34.4% cases were positive on Hb electrophoresis and 65.6% were negative. On electrophoresis, the number of sickle cell anemia cases was 34.3%, sickle cell trait – 20.8%, sickle beta-thalassemia – 29.8% and beta-thalassemia major – 29.8% was observed. In hemoglobinopathies, of the 73 females, 28.8% were having beta-thalassemia trait, 27.4% were having SCA 23.3% were having sickle beta-thalassemia, and 20.5% were having sickle cell trait. Of the 105 males, 30.5% were having beta-thalassemia trait, 9.5% were having sickle beta-thalassemia, 39.0% were having SCA, and 21.0% were having sickle cell trait. Conclusion: The ANMs, ASHA, and Anganwadis should be taught about the importance of screening of hemoglobinopathies. So that they can explain the purpose of screening to the female during pregnancy and to the families in the rural areas. At primary level, the CHCs and PHCs should be equipped with instruments for basic testing of hemoglobinopathies.

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Spectrum of Haemoglobinopathies in a Suburb of Indore (India): A Two Year Study

Cited by 2 publications

References 0 publications

Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Evaluation of Microcytic Hypochromic Anemia by Electrophoresis for Hemoglobinopathies in Young Population

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