Spectrum of FDG PET/CT Findings of Uterine Tumors

Kitajima, Kazuhiro; Murakami, Koji; Kaji, Yuichi; Sugimura, Kazuro

doi:10.2214/ajr.09.4074

Cited by 113 publications

(58 citation statements)

References 13 publications

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“…However, if the malignant change manifests as a discrete mass within adenomyosis, it can be detectable on MRI as in our case. On in benign uterine lesions such as leiomyomas [10]. In our case, MRI demonstated a subserosal, predominantly cystic mass with solid areas in the uterus.…”

Section: Discussionsupporting

confidence: 48%

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Kh²,

Kim³

et al. 2011

BJR

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ABSTRACT. There are several reports of adenocarcinoma developing within adenomyosis of the uterus, but imaging features of MRI, including diffusion-weighted imaging (DWI) and positron emission tomography (PET)-CT, have not been published. Herein we report a rare case of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis to emphasise the unusual growth features, as well as the imaging findings of the tumour on MRI and PET-CT.

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Section: Discussionsupporting

confidence: 48%

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Kh²,

Kim³

et al. 2011

BJR

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“…2.5), only 3 patients had high scores and 2 had negative scores in GLUT-1 expression. Although the expression of GLUT-1 may be a major cause for the high 18 F-FDG uptake in uterine tumors, other factors are also related such as expression of hexokinase II (31), tumor cell proliferation, hormonal dependency, microvessel density, and the presence of inflammatory cells (5). 18 F-FDG uptake includes many complicated factors, and it would be difficult to make a differential diagnosis in mesenchymal uterine tumors using 18 F-FDG SUV alone.…”

Section: Discussionmentioning

confidence: 99%

¹⁸F-FES and ¹⁸F-FDG PET for Differential Diagnosis and Quantitative Evaluation of Mesenchymal Uterine Tumors: Correlation with Immunohistochemical Analysis

et al. 2013

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The aim of this study was to investigate the relationship between the tumor uptake of 16a-18 F-fluoro-17b-estradiol ( 18 F-FES) and 18 F-FDG using PET and expressions of sex hormone receptors, such as estrogen receptor (ER), as well as glucose transporter 1 (GLUT-1) and Ki-67 analyzed by the immunohistochemistry method in mesenchymal uterine tumors. Methods: Forty-seven patients with mesenchymal uterine tumors were studied with 18 F-FES and 18 F-FDG PET. Postoperative pathologic diagnosis revealed 33 uterine leiomyomas and 14 uterine sarcomas. Tissue samples were assayed for expression of ERa, ERb, progesterone receptor (PR), PR-B, GLUT-1, and Ki-67 by an immunohistochemistry method. Standardized uptake values (SUVs) for 18 F-FES and 18 F-FDG were compared with the semiquantitative immunoreactive score (0-12) and quantitative labeling index (LI) for Ki-67 in immunohistochemistry. Results: 18 F-FES uptake was significantly lower (P , 0.001) and the 18 F-FDG uptake and SUV ratio of 18 F-FDG to 18 F-FES ( 18 F-FDG/ 18 F-FES ratio) (P , 0.005 and P , 0.001, respectively) were significantly higher in uterine sarcomas than in leiomyomas. Immunohistochemistry analysis showed significantly higher expressions of ERa, PR, and PR-B in uterine leiomyomas than in sarcomas. The Ki-67 LI was significantly greater in uterine sarcomas than in leiomyomas. Correlation analysis for all tumors showed positive correlations between 18 F-FES SUV and immunohistochemistry scores of ERa, PR (P , 0.001), and PR-B (P , 0.005) as well as between 18 F-FDG SUV and GLUT-1 and Ki-67 (P , 0.001). However, the 18 F-FDG/ 18 F-FES ratio showed significantly negative correlations with ERa, PR (P , 0.001), and PR-B (P , 0.005) and a positive correlation with Ki-67 LI (P , 0.001). In uterine sarcomas, ERa and 18 F-FES SUV showed a positive correlation (P , 0.001) in a low SUV range, and the 18 F-FDG/ 18 F-FES ratio showed positive correlations with ERb and GLUT-1 expression (P , 0.005). Conclusion: 18 F-FES and 18 F-FDG PET showed correlations between tracer uptake and expressions of sex hormone receptors, GLUT-1, and Ki-67 in mesenchymal uterine tumors. The 18 F-FDG/ 18 F-FES ratio was correlated with Ki-67, GLUT-1, and ERb in uterine sarcoma. Functional PET imaging and PET parameters would be useful noninvasive biomarkers for the assessment of tumor hormone receptor expression, glucose metabolism, and proliferation and for differential diagnosis of uterine leiomyoma and sarcoma.

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“…In addition, PET cannot reliably differentiate leiomyosarcoma from leiomyoma. 7) However, few reports of pleural leiomyomas describe MRI or PET examination. Such studies may be useful for diagnosis if the numbers of cases increase.…”

Section: Discussionmentioning

confidence: 99%

Giant Leiomyoma Arising from the Mediastinal Pleura: A Case Report

Haratake

Fukushima

Kozuma

et al. 2017

ATCS

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Spectrum of FDG PET/CT Findings of Uterine Tumors

Abstract: Benign uterine tumors generally have mild FDG uptake, and leiomyoma rarely shows high uptake. Uterine malignant tumors generally have intense FDG uptake, whereas malignant uterine tumors that are small or that have low cellular density often show minimal uptake.

Cited by 113 publications

References 13 publications

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

¹⁸F-FES and ¹⁸F-FDG PET for Differential Diagnosis and Quantitative Evaluation of Mesenchymal Uterine Tumors: Correlation with Immunohistochemical Analysis

Giant Leiomyoma Arising from the Mediastinal Pleura: A Case Report

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Spectrum of FDG PET/CT Findings of Uterine Tumors

Abstract: Benign uterine tumors generally have mild FDG uptake, and leiomyoma rarely shows high uptake. Uterine malignant tumors generally have intense FDG uptake, whereas malignant uterine tumors that are small or that have low cellular density often show minimal uptake.

Cited by 113 publications

References 13 publications

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

18F-FES and 18F-FDG PET for Differential Diagnosis and Quantitative Evaluation of Mesenchymal Uterine Tumors: Correlation with Immunohistochemical Analysis

Giant Leiomyoma Arising from the Mediastinal Pleura: A Case Report

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¹⁸F-FES and ¹⁸F-FDG PET for Differential Diagnosis and Quantitative Evaluation of Mesenchymal Uterine Tumors: Correlation with Immunohistochemical Analysis