Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Sh, Heo; Kh, Lee; Kim, Jin Woong; Yy, Jeong

doi:10.1259/bjr/24318075

Cited by 14 publications

(10 citation statements)

References 11 publications

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“…The incidence of adenomyosis in women with endometrioid adenocarcinoma ranges between 10 and 70% [71]. The exact prevalence is difficult to determine because of the relatively small case series available and because of the lack of consistency in diagnosing adenomyosis [113].…”

Section: Resultsmentioning

confidence: 99%

“…Other rare malignancies identified in adenomyosis or its variants include adenosarcoma [70] and endometrioid adenocarcinoma arising from subserosal cystic adenomyosis [65, 71]. The exact number of cases reported in literature is difficult to determine as classification of many of the cases has been disputed, but considering the authors’ original classification, the total number of cases of malignancy originating in adenomyosis is in the region of 78 cases.…”

Section: Endometrial Cancer Arising Within Adenomyotic Focimentioning

confidence: 99%

See 1 more Smart Citation

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

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To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.

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Section: Resultsmentioning

confidence: 99%

Section: Endometrial Cancer Arising Within Adenomyotic Focimentioning

confidence: 99%

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

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“…However, solid areas of the mass were clearly enhanced on gadolinium-enhanced T1weighted images in our case as well as in the case of previously reported endometrioid adenocarcinoma arising from cystic adenomyosis. 11 These facts indicate that MRI with contrast enhancement will be useful for detecting the malignant transformation of the intrauterine cystic lesions.…”

Section: Discussionmentioning

confidence: 98%

“…reviewed the published work and reported that only 44 cases of malignant transformation of adenomyosis have been documented so far . Furthermore, reported malignant neoplasms originating from cystic adenomyosis are much more rarely available; only one case of clear cell adenocarcinoma arising from a giant cystic adenomyosis, and only one case of endometrioid adenocarcinoma arising from cystic adenomyosis have been documented to date. Other types of malignant transformation of cystic adenomyosis have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Rare case of endometrioid adenocarcinoma arising from cystic adenomyosis

Mori

Furusawa

Kino

et al. 2014

J of Obstet and Gynaecol

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Few reports on malignant transformation of adenomyosis are available, and endometrioid adenocarcinoma arising from cystic adenomyosis is further rarely reported. We report a case of a 67-year-old asymptomatic woman who was referred to our hospital for evaluation of a cystic lesion in the pelvis, which had been diagnosed as cystic degeneration of leiomyoma for 3 years. Magnetic resonance imaging revealed a cystic mass measuring 11 cm in diameter, which was contiguous with uterine myometrium. The lesion contained solid areas enhanced on gadolinium-enhanced T1 -weighted imaging. Transabdominal simple total hysterectomy with bilateral salpingo-oophorectomy was performed. Pathological examination revealed endometrioid adenocarcinoma arising from cystic adenomyosis. The patient underwent six courses of adjuvant combination chemotherapy with paclitaxel and carboplatin. No metastasis or recurrence has been demonstrated for 16 months following surgery. Our case demonstrates that cystic adenomyoma possesses the risk of malignant transformation, indicating the importance of long-term follow-up with imaging examination.

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“…Rolly published the first report in 1897 (55). In our review, to date, 44 cases of malignant tumors arising from adenomyosis have been documented (48,51,(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70).…”

Section: Malignant Transformation Of Adenomyosismentioning

confidence: 99%

Pathogenesis and malignant transformation of adenomyosis (Review)

et al. 2012

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Abstract. The aim of our review was to identify the current information with regard to the pathogenesis and malignant transformation of adenomyosis. The current literature was reviewed by searching MEDLINE/PubMed, using the following keywords: adenomyosis, myometrium, stromal cells, malignant transformation, pathogenesis, etiology, genome-wide and microarray. Early signs of the development of adenomyosis are considered to be the penetration of stromal cells into the inner layer of the myometrium. Adenomyosis smooth muscle cells are developed, possibly, through a remodeling pathway via reactivation of coelomic epithelial cells as a result of estrogeninduced epithelial mesenchymal transition. Smooth muscle cell hyperplasia and hypertrophy are a reflection of a reaction of the surrounding tissue. The development of adenocarcinoma arising from adenomyosis is a relatively rare occurrence. In our literature review, to date, 44 cases of malignant tumors arising from adenomyosis have been documented. Studies reporting results of genetic abnormalities, epigenetic changes, monoclonal expansion, mutational analysis and the inactivation of specific tumor suppressor genes are very few in this field. In conclusion, adenomyosis can be a precursor of some carcinomas. The exact molecular mechanisms that lead to the malignant transformation are poorly understood.

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Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Cited by 14 publications

References 11 publications

Adenomyosis and Endometrial Cancer: Literature Review

Adenomyosis and Endometrial Cancer: Literature Review

Rare case of endometrioid adenocarcinoma arising from cystic adenomyosis

Pathogenesis and malignant transformation of adenomyosis (Review)

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