Spectrum of clinico-pathological profile and treatment response in children with nephrotic immunoglobulin a nephropathy

Pradhan, Subal Kumar; Sivaraj, Pradeep; Das, Leena; Swain, Arakhita

doi:10.4103/1319-2442.160149

Cited by 2 publications

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“…Nephrotic syndrome is a chronic condition of childhood with around 80-90% chances of relapse. 5 This study population showed a similar percentage of relapses (88%). The relapse pattern is thought to be dependent on numerous factors by various investigators i.e.…”

Section: Discussionsupporting

confidence: 56%

Prediction of relapses in children with idiopathic steroid sensitive nephrotic syndrome: a retrospective study

Prasun

Payas

Sujaya

2017

Int J Contemp Pediatr

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Frequent relapsers are at high risk of developing complications related to steroid therapy as they need repeated courses of steroid for treatment. If such relapses could be fairly predicted at the onset of disease, it would lead to a better long term management of the disease. The purpose of our study is to identify the factors at the onset ABSTRACT Background: Nephrotic syndrome is a chronic recurrent disease commonly affecting children belonging to the age group 1-10 years. The purpose of the study was to identify the factors at the onset of disease responsible for relapses in nephrotic syndrome. Methods: It was a retrospective observational study conducted in a tertiary care hospital in North India consisting of children aged 1-15 years diagnosed as nephrotic syndrome (1 st episode) and followed for 12 months. Variables extracted from records (after January 2008) were age of presentation, days to remission, hematuria, and hypertension. Results: Out of 88 cases, 23 were frequent relapsers and 65 were infrequent relapsers. It was observed that cases remitting after 2 weeks have increased chances of frequent relapses. On stratification based on presence or absence of hematuria or hypertension, it was observed that both these variables predispose the patient towards frequent relapses. Conclusions: We concluded that variables like days to remission, haematuria and hypertension can fairly predict future relapses.

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Section: Discussionsupporting

confidence: 56%

Prediction of relapses in children with idiopathic steroid sensitive nephrotic syndrome: a retrospective study

Prasun

Payas

Sujaya

2017

Int J Contemp Pediatr

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Risk factors for relapse in childhood steroid sensitive nephrotic syndrome

Balaji¹,

Kumaravel²,

Punitha³

et al. 2017

Indian J Child Health

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Background: Nephrotic syndrome (NS) generally tends to follow a benign and chronic relapsing course. Relapses are a major problem in children with steroid sensitive NS (SSNS). Objective: To identify the risk factors for frequent relapse (FR) in the first episode childhood SSNS. Methods: This prospective study was conducted in the Government Dharmapuri Medical College Hospital, Tamil Nadu, between July 2013 and January 2016. Children aged 9 months - 12 years with a diagnosis of SSNS (first episode) who came for follow-up for at least 12 months in the pediatric nephrology clinic were included. The enrolled cases were divided into 2 groups: (1) frequent relapser (FR) and (2) infrequent relapser (IFR). 9 factors were studied as possible risk factorsfor relapse. The data collected were analyzed using Chi-square test and Student’s t-test. Results: Of 160 SSNS children, there were 92 (57.5%) cases of IFR and 68 (42.5%) cases of FR. There were 97 males (60.6%) and 63 females (39.4%) with a male to female ratio of 1.5:1. The mean age of presentation was 4.37±2.32 years. The mean time taken to achieve remission during the first episode was 1.94±1.04 weeks. The interval between remission and first relapse was 5.56±4.51 months. Incidence of infection and hypertension was 31.9% and 37.5%, respectively. Risk factors significantly associated with FR were: Time taken to achieveremission during the first episode (>14 days) (p<0.0001), mean duration of interval between remission and first relapse (within 6 months) (p<0.0001), associated infections (p<0.0001) and hypertension (p<0.0001). Age at onset, sex, serum albumin, 24 h urine protein, and azotemia did not influence the FR in our study. Conclusion: More than 14 days to achieve remission during the first episode, relapse within first 6 months, associated infections and hypertension were the factors associated with FRs.

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Spectrum of clinico-pathological profile and treatment response in children with nephrotic immunoglobulin a nephropathy

Cited by 2 publications

References 1 publication

Prediction of relapses in children with idiopathic steroid sensitive nephrotic syndrome: a retrospective study

Prediction of relapses in children with idiopathic steroid sensitive nephrotic syndrome: a retrospective study

Risk factors for relapse in childhood steroid sensitive nephrotic syndrome

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