Spectrum of Causative Pathogens and Resistance Rates to Antibacterial Agents in Bacterial Prostatitis

Abstract

Objective: To evaluate spectrum and resistance rates to antibacterial agents in causative pathogens of bacterial prostatitis in patients from Southern Europe, the Middle East, and Africa. Materials: 1027 isolates from cultures of urine or expressed prostatic secretion, post-massage urine or seminal fluid, or urethral samples were considered. Results: Escherichia coli (32%) and Enterococcus spp. (21%) were the most common isolates. Other Gram-negative, Gram-positive, and atypical pathogens accounted for 22%, 20%, and 5%, respectively. Resistance was <15% for piperacillin/tazobactam and carbapenems (both Gram-negative and -positive pathogens); <5% for glycopeptides against Gram-positive; 7%, 14%, and 20% for aminoglycosides, fosfomycin, and macrolides against Gram-negative pathogens, respectively; 10% for amoxicillin/clavulanate against Gram-positive pathogens; <20% for cephalosporins and fluoroquinolones against to Gram-negative pathogens (higher against Gram-positive pathogens); none for macrolides against atypical pathogens, but 20% and 27% for fluoroquinolones and tetracyclines. In West Africa, the resistance rates were generally higher, although the highest rates for ampicillin, cephalosporins, and fluoroquinolones were observed in the Gulf area. Lower rates were observed in Southeastern Europe. Conclusions: Resistance to antibiotics is a health problem requiring local health authorities to combat this phenomenon. Knowledge of the spectrum of pathogens and antibiotic resistance rates is crucial to assess local guidelines for the treatment of prostatitis.

Microbial etiology of bacterial chronic prostatitis: systematic review

“…Este análisis etiológico no ha tenido en cuenta los estudios de Choi Y et al [ 17 ], Wan CD et al [ 7 ] y Trinchieri A et al [ 18 ] ya que, la información relacionada con el número de microorganismos aislados solo se presenta en forma de porcentaje, sin especificar el número absoluto de bacterias que corresponde a cada valor porcentual.…”

“…En relación con el análisis que nos ocupa, debemos discutir en último lugar el papel trimetoprim-sulfametoxazol. En la revisión observamos cómo, a excepción de Cai T et al [ 10 ], la tasa de resistencia antibiótica es elevada: 31,5% en el estudio de Seo Y et al [ 8 ] y 96% en el trabajo de Trinchieri et al [ 18 ]. En lo referente a E. coli , el porcentaje medio de resistencia en todos los estudios oscila en torno al 20-25%, encontrando Seo Y et al [ 8 ] una tasa de resistencia superior (31,5%).…”

Innate Immune Program in Formation of Tumor-Initiating Cells from Cells-of-Origin of Breast, Prostate, and Ovarian Cancers

“…Chronic bacterial prostatitis is defined as recurrent UTIs with the same organism in prostatic secretions during asymptomatic periods [120]. The most common pathogenic agents of chronic bacterial prostatitis are also Escherichia coli or other Gram-negative Enterobacteriaceae [121].…”

In Vitro Modelling of Chlamydia trachomatis Infection in the Etiopathogenesis of Male Infertility and Reactive Arthritis

“…Prostatitis, one of the most common urologic problems for men younger than 50 years, and risk factor for infertility (Khan et al, 2017), has a prevalence of approximately 8% to 16%, and around 5% to 10% of all cases have a bacterial origin, with C. trachomatis involved in up to 27% of all bacterial infections of the prostate (Ostaszewska et al, 1998;Badalyan et al, 2003;Krieger et al, 2008;Ouzounova-Raykova et al, 2010;Trinchieri et al, 2021). Nevertheless, chronic bacterial prostatitis is frequently underestimated because urinary tract infections often remain undocumented and thus neglected (Ouzounova-Raykova et al, 2010).…”