Background: Breast lesions shows a wide spectrum of lesions including inflammatory, benign, and malignant conditions. This spectrum varies according to sex, age, regional geographical factors. There are diverse regional and environmental conditions which affects the cytomorphological spectrum of breast lesions in Kumaon region. Methods: A retrospective study was carried out in Department of Pathology, Government Medical College from March 2015 to February 2019. A total of 414 cases were included in the study and lesions were divided into inflammatory, benign, and malignant conditions. Result: A total of 414 cases were included in the study and divided into three broad categories including inflammatory, benign, and malignant lesions. 65 cases (15.7%) were inflammatory, 295 cases were benign (71.26%), and 54 cases (13.04%) were malignant. Among benign lesions, most common age group was 21 to 30 years and in malignant lesions, most common age group were 31 to 40 years and 41 to 50 years. Conclusion: Wide spectrum of lesions can be seen in breast including inflammatory, benign, and malignant conditions. They may show overlap of signs and symptoms in different age groups. Different parameters like age, sex, laterality and quadrant helps in diagnosing its cytomorphological spectrum.