Spectroscopy properties of the amide group in valpromide and some derivatives with antiepileptic activity

Massa, N. E.; Castro, Eduardo A.; Jubert, Alicia H.

doi:10.1002/jrs.2322

Cited by 5 publications

(2 citation statements)

References 23 publications

(17 reference statements)

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“…The IR spectrum of 2,2-diethylacetamide 3 (Figure 4, black trace) is very similar to its spectrum in KBr pellets reported by Jart [21]. It is also similar to IR spectra of homologous acetamides (acetamide, propionamide, butyramide, isobutyramide, isovaleramide, valpromide) [21,22].…”

Section: Ir Spectra 15supporting

confidence: 79%

Distinct molecular structures and hydrogen bond patterns of α,α-diethyl-substituted cyclic imide, lactam, and acetamide derivatives in the crystalline phase

Krivoshein

Ordonez

Khrustalev

et al. 2016

Journal of Molecular Structure

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,-Dialkyland -alkyl--aryl-substituted cyclic imides, lactams, and acetamides show promising anticonvulsant, anxiolytic, and anesthetic activities. While a number of crystal structures of various -substituted cyclic imides, lactams, and acetamides were reported, no indepth comparison of crystal structures and solid-state properties of structurally matched compounds have been carried out so far. In this paper, we report molecular structure and intermolecular interactions of three ,-diethyl-substituted compounds-3,3-diethylpyrrolidine-2,5-dione, 3,3-diethylpyrrolidin-2-one, and 2,2-diethylacetamide-in the crystalline phase, as studied using single-crystal X-ray diffraction and IR spectroscopy. We found considerable differences in the patterns of H-bonding and packing of the molecules in crystals. These differences correlate with the compounds' melting points and are of significance to physical pharmacy and formulation development of neuroactive drugs.

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Section: Ir Spectra 15supporting

confidence: 79%

Distinct molecular structures and hydrogen bond patterns of α,α-diethyl-substituted cyclic imide, lactam, and acetamide derivatives in the crystalline phase

Krivoshein

Ordonez

Khrustalev

et al. 2016

Journal of Molecular Structure

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“…Amide groups contribute significantly to the protein structure. A variety of techniques such as IR, NMR, Raman, ultrasonic absorption, and UV/Vis spectroscopies have been used to characterize both the intermolecular and intramolecular bonding in amide compounds [19][20][21][22]. Salicylamide is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Absorption Spectroscopy of Benzamide, Acrylamide, Caprolactam, Salicylamide, and Sulfanilamide in the Solid State

Jiang

Zhou

Wen

et al. 2014

Journal of Spectroscopy

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Terahertz (THz) absorption spectra of the similarly structured molecules with amide groups including benzamide, acrylamide, caprolactam, salicylamide, and sulfanilamide in the solid phase at room temperature and 7.8 K for salicylamide are reported and compared to infrared vibrational spectral calculations using density functional theory. The results of THz absorption spectra show that the molecules have characteristic bands in the region of 0.2–2.6 THz (~7–87 cm−1). THz technique can be used to distinguish different molecules with amide groups. In the THz region benzamide has three bands at 0.83, 1.63, and 1.73 THz; the bands are located at 1.44 and 2.00 THz for acrylamide; the bands at 1.24, 1.66 and 2.12 THz are observed for caprolactam. The absorption bands are located at 1.44, 1.63, and 2.39 THz at room temperature, and at 1.22, 1.46, 1.66, and 2.41 THz at low temperature for salicylamide. The bands at 1.63, 1.78, 2.00, and 2.20 THz appear for sulfanilamide. These bands in the THz region may be related to torsion, rocking, wagging, and other modes of different groups in the molecules.

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Recent advances in linear and nonlinear Raman spectroscopy. Part IV

Nafie

2010

J Raman Spectroscopy

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The purpose of the review is to provide a concise overview of recent advances in the broadly defined field of Raman spectroscopy as reflected in part by the many articles published each year in the Journal of Raman Spectroscopy (JRS) as well as in trends across all related journals publishing in this research area. Context for the review is provided by considering statistical data on citations for the Thompson Reuters ISI Web of Science by year and by subfield of Raman spectroscopy. Additional statistics of number of papers and posters presented by category at the XXII International Conference on Raman Spectroscopy (ICORS 2010) is also provided. Papers published in JRS in 2009, as reviewed here, reflect trends at the cutting edge of Raman spectroscopy which is expanding rapidly as a sensitive photonic probe of matter at the molecular level with an ever widening sphere of novel applications.

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Spectroscopy properties of the amide group in valpromide and some derivatives with antiepileptic activity

Cited by 5 publications

References 23 publications

Distinct molecular structures and hydrogen bond patterns of α,α-diethyl-substituted cyclic imide, lactam, and acetamide derivatives in the crystalline phase

Distinct molecular structures and hydrogen bond patterns of α,α-diethyl-substituted cyclic imide, lactam, and acetamide derivatives in the crystalline phase

Terahertz Absorption Spectroscopy of Benzamide, Acrylamide, Caprolactam, Salicylamide, and Sulfanilamide in the Solid State

Recent advances in linear and nonlinear Raman spectroscopy. Part IV

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