Spectroscopic, thermal and electrochemical studies on some nickel(II) thiosemicarbazone complexes

El-Shazly, Rafat M.; Al‐Hazmi, Gamil A.A.; Ghazy, S. E.; El-Shahawi, M.S.; El‐Asmy, Ahmed A.

doi:10.1016/j.saa.2004.02.035

Cited by 87 publications

(34 citation statements)

References 28 publications

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“…In addition of this, they have been screened for their medical properties because they possess some cytotoxic effect. They also stabilize uncommon oxidation states, generate a different coordination number in transition metal complexes in order to participate in various redox reactions [16,17]. It is well known that several metal ions enhance and modify the biological activities of thiosemicarbazones [13].…”

Section: Introductionmentioning

confidence: 99%

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

Melha¹

2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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-(7 0 -chloroquinolin-4 0 -ylamino)thiosemicarbazide with 2-hydroxybenzaldehyde. The structures of the complexes were determined on the basis of the elemental analyses, spectroscopic data (IR, electronic, 1 H and 13 C NMR and Mass spectra) along with magnetic susceptibility measurements, molar conductivity and thermogravimetric analyses. Electrical conductance measurement revealed the non-electrolytic nature of the complexes. The resulting colored products are mononuclear in nature. On the basis of the above studies, only one ligand was suggested to be coordinated to each metal atom by thione sulfur, azomethine nitrogen and phenolic oxygen to form mononuclear complexes in which the thiosemicarbazone behaves as a monobasic tridendate ligand. The ligand and its metal complexes were tested against Gram þ ve bacteria (Staphylococcus aureus), Gram 2 ve bacteria (Escherichia coli), fungi (Candida albicans) and (Fusarium solani). The tested compounds exhibited significant activity.

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Section: Introductionmentioning

confidence: 99%

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

Melha¹

2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Therefore, from the IR spectra, it is concluded that the reported ligand behaves as neutral pentadentate in all the complexes and coordinates to the metal ion via the pyridyl nitrogen, the two nitrogen atoms of the primary amine groups and the two sulfur atoms of the ligand system. The low frequency bands in all the complexes in the region 535 -570 cm -1 and 421 -455 cm -1 are assigned to υ(Cu-N) and υ(Cu-S), respectively and provide a compelling evidence for the presence of metal-nitrogen and metal-sulfur bond in the complexes molecules [20,21]. For all complexes medium to strong bands present in the region around 4500 cm −1 , assignable to υ(OH), clearly confirm the presence of surface or lattice water.…”

Section: Ir Spectral Studies:-mentioning

confidence: 84%

Synthesis and Characterization of N3s2 Donors Macrocyclic Copper(ii) Complexes. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity.

Ramadan¹,

Shaban²,

Khalil³

et al. 2017

IJAR

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A new series of hexa-, and five-coordinated copper(II) complexes, having the molecular formulae of [CuLX]X H 2 O, 1, 2, 3 (X = Cl¯, Br¯, NO 3¯) and [CuL]X 2 nH 2 O, 4, 5 (X= AcO¯ and ClO 4¯) respectively and L is pentadentate pyridine based ligand have been synthesized. Structural characterization of these newly synthesized compounds was achieved by several physicochemical methods including elemental and thermal analysis (TGA and DTG), electrical molar conductance, magnetic moment measurements and spectral investigations such as IR, UV-Vis and ESR. The spectral and magnetic measurements in addition to the electrolytic conductance results demonstrated the octahedral and square-pyramidal stereochemistries for the hexa, and five coordinated copper(II) chelates respectively. Catechol oxidase and phenoxazinone synthase biomimetic catalytic activity of the inspected copper(II) chelates was studied and the results obtained indicated that, the catalytic reactivity is markedly depends on the structural properties of these newly synthesized copper(II) complexes. …………………………………………………………………………………………………….... Introduction:-Functional models of the metalloenzymes that activate molecular oxygen possess great potential as catalyst for specific oxidation reactions and as guides for the development of efficient small molecule catalysts [1]. Since, the oxidation of organic substrates with molecular oxygen under mild conditions is of great interest for industrial [2] and synthetic processes both from an economical and environmental [3] point of view, most of the focus of ongoing biomimetic and bioinspired synthetic approaches is on reproducing some structural and/or functional feature of the title enzymes. The synthesis and reactivity studies of transition metal complexes, as functional model compounds for metalloenzymes with oxidase activity, are of particular interest for the development of bioinspired catalysts for oxidation reactions.The potential role played by copper ions in the active sites of a large number of metalloproteins has stimulated efforts to design and characterize copper complexes as models for providing better understanding of biological systems and for assisting in the development of new homogeneous catalysts for selective oxidation. Particularly, the

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“…39,40) The low intensities of the d-d bands compared to intra-ligand and metal to ligand charge transfer absorptions prevent an accurate assignment for the C4 com- plex. The Zn(II) complex has not shown any d-d absorptions.…”

Section: Resultsmentioning

confidence: 99%

A Study of Anti-inflammatory and Analgesic Activity of New 2,3-Disubstituted 1,2-Dihydroquinazolin-4(3H)-one Derivative and Its Transition Metal Complexes

Hunoor

Patil

Badiger

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Quinazolinones and their derivatives have drawn much attention owing to their various pharmacological properties. They exhibit diverse biological properties like, antimicrobial, [1][2][3] antiviral, 4) anticancer, 5) anticonvulsant, 6) CNS depressant 7) and antihypertensive activity. 8) Amongst these, C-2 and N-3 disubstituted quinazolines with aryl and heteroaryl groups at N-3 position have shown enhanced anti-inflammatory activity as a result of their nitric oxide inhibitory activities. 9)A good deal of research has been carried out on the coordinating behavior of 2,3-disubstituted quinazolin-4(3H)-ones which offer various potential donor sites. [10][11][12][13][14][15] In comparison, 2,3-disubstituted 1,2-dihydroquinazolinones and their metal complexes are not much explored. We have recently reported the synthesis of 1,2-dihydroquinazolinones by the condensation of 2-aminobenzoylhydrazide with aryl and heteroaryl aldehydes and their chelating behavior towards transition and inner transition metal ions. [16][17][18][19][20][21][22] Their antimicrobial potency is also tested against different bacterial and fungal strains. Our continued research in this perspective resulted in a new approach, in which 2-aminobenzoylhydrazide is converted to hydrazone in the first step. The reaction of this hydrazone with aromatic aldehydes results in the formation of biologically active 1,2-dihydroquinazolinones, with different substituent at C-2 and N-3 positions.Aroylhydrazones of salicylaldehyde, which typically act as tridentate planar chelate coordinating through phenolic oxygen, amide oxygen and imine nitrogen (Chart 1a) are known for their interesting biological activities.23) Keeping the framework of coordinating sites of aroylhydrazones intact, we have designed quinazoline analogue (Chart 1b) of aroylhydrazone of o-hydroxyacetophenone which is structurally similar with aroylhydrazones of salicylaldehyde. Recent investigation show that coordination of organic molecules and anti-inflammatory drugs with Co(II), Ni(II), Cu(II), Fe(II) and Zn(II) metal ions resulted in the enhancement of their activity. [24][25][26] Thus, the present article charts the progress of our methodology in the synthesis of new 1,2-dihydroquinazolin-4(3H)-one derivative viz., 2-hydroxy-2-ethyl-(3-carboxylideneamino)-3-(2-(4-methyl-phenyl))-1,2-dihydroquinazolin-4(3H)-one (HECMDQ) (C1) with different substituent at C-2 and N-3 positions and its coordinating behavior towards Co(II), Ni(II), Cu(II) and Zn(II) ions. The results of analgesic activity are impressive and perhaps suggestive of future success. ExperimentalMaterials Methylanthranilate (S.D. Fine Chemicals, India), hydrazinehydrate (Spectrochem, India) o-hydroxyacetophenone (Himedia, India), pmethylbenzaldehyde (Spectrochem, India) and metal(II) chlorides used in the present study were of AR grade and used as supplied. All the solvents were distilled before use. o-Aminobenzoylhydrazide 27) and o-hydroxyacetophenone-o-aminobenzoylhydrazone 28) were prepared following the literature procedures.P...

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Spectroscopic, thermal and electrochemical studies on some nickel(II) thiosemicarbazone complexes

Cited by 87 publications

References 28 publications

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

Synthesis and Characterization of N3s2 Donors Macrocyclic Copper(ii) Complexes. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity.

A Study of Anti-inflammatory and Analgesic Activity of New 2,3-Disubstituted 1,2-Dihydroquinazolin-4(3H)-one Derivative and Its Transition Metal Complexes

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Spectroscopic, thermal and electrochemical studies on some nickel(II) thiosemicarbazone complexes

Cited by 87 publications

References 28 publications

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N4-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N4-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

Synthesis and Characterization of N3s2 Donors Macrocyclic Copper(ii) Complexes. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity.

A Study of Anti-inflammatory and Analgesic Activity of New 2,3-Disubstituted 1,2-Dihydroquinazolin-4(3H)-one Derivative and Its Transition Metal Complexes

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In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide