In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N⁴-(7′-chloroquinolin-4′-ylamino) thiosemicarbazide

Abstract

-(7 0 -chloroquinolin-4 0 -ylamino)thiosemicarbazide with 2-hydroxybenzaldehyde. The structures of the complexes were determined on the basis of the elemental analyses, spectroscopic data (IR, electronic, 1 H and 13 C NMR and Mass spectra) along with magnetic susceptibility measurements, molar conductivity and thermogravimetric analyses. Electrical conductance measurement revealed the non-electrolytic nature of the complexes. The resulting colored products are mononuclear in nature. On the basis of the above studies, only one ligand was suggested to be coordinated to each metal atom by thione sulfur, azomethine nitrogen and phenolic oxygen to form mononuclear complexes in which the thiosemicarbazone behaves as a monobasic tridendate ligand. The ligand and its metal complexes were tested against Gram þ ve bacteria (Staphylococcus aureus), Gram 2 ve bacteria (Escherichia coli), fungi (Candida albicans) and (Fusarium solani). The tested compounds exhibited significant activity.

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“…(C=S) [20,21], which is shifted to lower wavenumber in metal chelates by 25 cm -1 to 50 cm -1 , indicating coordination of sulfur to metal atom. Which is further confirmed by band observed at 354 cm -1 to 326 cm -1 assigned for v(M-S) frequency [22,23]. The single band observed in the range of 3000 cm -1 to 3200 cm -1 which correspond to assignment of v(-NH-) stretch.…”

New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

“…Thiosemicarbazone derivatives and their metal complexes have been extensively explored in pharmacology due to their broad spectrum of biological activities, including antimicrobial, anticancer, and antiviral activities [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Thiosemicarbazones are known to have a general formula of R 1 R 2 C=N-NH-C=S-NR 3 R 4, which make them significant donor ligands through their hydrazine nitrogen and sulfur atoms.…”

Palladium (II) and platinum (II) complexes containing organometallic thiosemicarbazone ligands: Synthesis, characterization, X-ray structures and antitubercular evaluation

“…Several research groups have focused their studies on the development of new transition metal TSCs-containing compounds to be used (both in vitro and in vivo) as potential antiviral [15], antitumoral [16][17][18][19], antiparasital [20,21], antifungal [22,23] and antibacterial agents [24][25][26].…”