Spectroscopic studies on the utility of charge transfer interactions for determination of phenytoin sodium

Abstract

Electron donor acceptor complexes (EDA) of the phenytoin sodium (Pyn) as a rich donor with different π-acceptors like p-chloranil (p-CHL), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), tetracyanoquinodimethane (TCNQ), chloranilic acid (CLA), N-bromosuccinimide (NBS) and picric acid (PA) have been synthesized. Spectroscopic and physical data such as formation constant (K CT ), molar extinction coefficient (ε CT ), standard free energy (∆G 0 ), oscillator strength (ƒ), transition dipole moment (μ), resonance energy (R N ) and ionization potential (I p ) have been determined. Based on the elemental analysis and photometric titrations the CT-complexes were found to have 1 : 1 stoichiometry.

Visible-Light-Mediated (sp3)Cα–H Functionalization of Ethers Enabled by Electron Donor–Acceptor Complex

“…The above results offer compelling evidence to rationalize the mechanism. Based on the mechanistic experiments and literature precedence, 48 we envisioned that the reaction initiated by forming an activated colored NBS-THF EDA complex I. Irradiation of this EDA complex I by visible light (blue or purple LEDs) facilitates the generation of radical cation II and radical anion III. Elimination of bromine radical IV leads to the formation of anionic species V. Intermediate V then abstracts one proton from intermediate II to deliver the THF radical VII.…”

Determination of phenytoin in exhaled breath condensate using electromembrane extraction followed by capillary electrophoresis

“…Analytical methods for determination of AEDs, including PHT, have been reviewed in a previous articles [4]. PHT alone and PHT in combination with other AEDs have been determined using a number of analytical techniques including colorimetric [5], spectrophotometric [6,7], immunoassay [8–10], HPLC‐UV [11–19], LC–MS/MS [20–22], GC with a thermionic specific detector (GC‐TSD) [23], and MEKC [24]. Immunoassay methods are rapid and accurate [25] but their reagents are more expensive [2].…”