Spectroscopic studies on the in vitro antioxidant capacity of isopentyl ferulate

Machado, Keylla C.; Oliveira, George Laylson da Silva; Sousa, Élida Batista Vieira de; Costa, Iwyson Henrique Fernandes da; Machado, Kátia Conceição; Sousa, Damião Pergentino de; Satyal, Prabodh; Freitas, Rivelilson Mendes de

doi:10.1016/j.cbi.2014.11.008

Cited by 16 publications

(9 citation statements)

References 35 publications

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“…Moreover, an antioxidant capacity against the hydroxyl radical and nitric oxide were also evaluated as well as the inhibition of lipid peroxidation by TBARS method. 20…”

Section: Oh Coohmentioning

confidence: 99%

Natural antioxidants–properties and possible applications

Żymańczyk–Duda¹,

Szmigiel-Merena²,

Brzezińska-Rodak³

et al. 2018

JABB

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There is an interest in the use of compounds able to prevent organism damages. Antioxidants are such compounds that can protect from cells damages caused by free radicals and may be used in the treatment and prevention on many diseases, such as cancer, cardiovascular disease, diabetes, brain stroke, skin diseases as well as they delay the aging process. There are many sources of antioxidants. They can be synthetic or natural and especially those derived from natural sources, demand special attention. Phenolic compounds are substances which mainly possess such activity, but also vitamins and minerals. There are a lot of antioxidants, but in that review, the chosen compounds with outstanding antioxidant activity, mainly used in pharmaceuticals and cosmetics were described. The review shows the activity of phenolic acids (ferulic acid and caffeic acid) and polyphenols (ellagic acid, curcumin, genistein, hydroxytyrosol, resveratrol) and vitamins (C and E).

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“…Moreover, an antioxidant capacity against the hydroxyl radical and nitric oxide were also evaluated as well as the inhibition of lipid peroxidation by TBARS method. 20…”

Section: Oh Coohmentioning

confidence: 99%

Natural antioxidants–properties and possible applications

Żymańczyk–Duda¹,

Szmigiel-Merena²,

Brzezińska-Rodak³

et al. 2018

JABB

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“…The hydroxyl of the aromatic ring plays an important role in the antioxidant activity via the homolytic fragmentation of the O-H bond [28, 29]. It has been reported that vanillin exhibited hydroxyl radical [30] and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS ∙ + ) [23] scavenging activities.…”

Section: Antioxidant and Prooxidant Effectsmentioning

confidence: 99%

Overview of the Role of Vanillin on Redox Status and Cancer Development

Bezerra

Soares

Sousa

2016

Oxidative Medicine and Cellular Longevity

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Bioactive natural products play critical roles in modern drug development, especially anticancer agents. It has been widely reported that various pharmacological activities of such compounds are related to their antioxidant properties. Vanillin is a natural substance widely found in many plant species and often used in beverages, foods, cosmetics, and pharmaceutical products. Antioxidant and anticancer potential have been described for this compound. Considering the importance of vanillin in the area of human health and food and pharmaceuticals sectors, in this review, we discuss the role of vanillin on redox status and its potential contribution to the prevention and the treatment of cancer.

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“…Natural compounds (MF, MpC, and PE) were prepared according to Machado et al (2015) and Lima et al (2014) in the laboratory of Prof. Dr. Damião Pergentino de Sousa, University of Paraíba, João Pessoa, PB, Brazil. Ethanol, D-glucose, potassium dichromate, sodium chloride, and potassium dihydrogen phosphate were purchased from Merck, Darmstadt, Germany.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

In vitroandin vivotoxicological evaluations of methyl ferulate, methylp-coumarate, and pulegone 1,2-epoxide

Raza

Muhammad

Sousa

et al. 2015

Pharmaceutical Biology

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Objectives: The objective of this study is to evaluate the toxicity of methyl ferulate (MF), methyl p-coumarate (MpC), and pulegone 1,2-epoxide (PE) with in vitro and in vivo assays. Materials and methods:The in vitro toxicity of MF, MpC, and PE was assessed at a concentration of 10 mg/ml with the Ames assay using two strains of Salmonella typhimurium TA98 and TA100.Human red blood cells (RBC) were used to determine the hemolytic activity of these compounds. The cytotoxicity of above compounds was determined with brine shrimp lethality bioassay (BSLB) at the concentrations of 0.1-20 mg/ml. While dermal and ocular irritation studies were conducted on healthy rabbits (n ¼ 8) for 96 and 12 h post-topical application of test compounds, respectively.Results: PE produced 6-8% hemolysis of RBCs at all the tested concentrations while MF and MpC produced 10-5% hemolysis up to 20 mg/ml, and 50-85% hemolysis at concentrations of 40 and 80 mg/ml, respectively. The Ames assay indicated that MF, MpC, and PE were nonmutagenic as the test values were not significantly higher as compared with background values of the assay. BSLB suggested the lethal concentration (LC 50 ) values of MF, MpC, and PE as 4.38, 6.74, and 25.91 mg/ml, respectively. In vivo ocular and dermal irritation scores of MF, MpC, and PE were comparable with ethanol (control) in rabbits indicating the non-irritant nature of these natural compounds. Conclusion:The present studies suggest that these compounds are non-toxic/non-irritant and might be used for medicinal purposes.

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Spectroscopic studies on the in vitro antioxidant capacity of isopentyl ferulate

Cited by 16 publications

References 35 publications

Natural antioxidants–properties and possible applications

Natural antioxidants–properties and possible applications

Overview of the Role of Vanillin on Redox Status and Cancer Development

In vitroandin vivotoxicological evaluations of methyl ferulate, methylp-coumarate, and pulegone 1,2-epoxide

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