Spectroscopic studies on the complexation of some transition metals with Chloramphenicol drug

Spectroscopic and thermal characterization of Cu(II), Co(II), Ni(II) and Mn(II) complexes of fluorescent dye 4-N,N-dimethyl-ethanolamine-N-allyl-1,8-naphthalimide (4DMEAN)

“…Conductivity measurements provide a method of testing the degree of ionization of the complexes, the molecular ions that a complex liberates in solution (in case of presence anions outside the coordination sphere), the higher will be its molar conductivity and vice versa [31][32][33][34]. It is clear from the obtained data that the complexes present seem to be non-electrolytes.…”

Enzymatic regioselective production of chloramphenicol esters

“…Furthermore, its efficiency in the treatment of tetracycline-resistant cholera, staphylococcal brain abscesses, meningitis, influenza, pneumonia, and several infections has effectively been demonstrated over the years. 4 Unfortunately, it can also produce adverse effects such as aplastic anaemia, bone marrow suppression, childhood leukemia, and gray baby syndrome, so this compound requires medical prescription. For the administration of this drug there are currently several ways, for instance capsules, oily or liquid form, but the bitter taste of the pharmaceutical has led to the production of different alternatives such as chloramphenicol succinate or chloramphenicol palmitate (2a, Figure 1) esters by selective modification of the primary hydroxyl group.…”

Synthesis, spectroscopic characterization, thermal analysis and electrical conductivity studies of Mg(II), Ca(II), Sr(II) and Ba(II) vitamin B2 complexes

“…The activation energies of decomposition were found to be in the range 30-127 kJ mol À1 . The high values of the activation energies reflect the thermal stability of the complexes [19][20][21][22][23]. The entropy of activation was found to have negative values in all the complexes which indicate that the decomposition reactions proceed with a lower rate than the normal ones.…”

“…Our research group has been trended in a synthesized, structural, spectroscopic characterization, thermal behavior and kinetic investigation of the thermal decomposition processes occurring through the metal ions drug interactions [16][17][18][19][20][21][22][23][24]. As a continuation in this trend, the main task of this paper is synthesized and characterizing the structures of the 1:2 metal:ligand Mg(II), Ca(II), Sr(II) and Ba(II) complexes with riboflavin and to interpretative in details its 0022-2860/$ -see front matter Ó 2011 Elsevier B.V. All rights reserved.…”