Spectroscopic characterization of both aqueous and solid-state diacerhein/hydroxypropyl-β-cyclodextrin inclusion complexes

Petralito, Stefania; Zanardi, Iacopo; Spera, Romina; Memoli, Adriana; Travagli, Valter

doi:10.1016/j.saa.2014.02.055

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…The inclusion complex between fluconazole and HP-

-CD was prepared with 1:1 molar ratio by the kneading method [ 27 ]. Equimolar amounts of the two components were ground in a mortar until a homogeneous mixture was obtained.…”

Section: Materials and Methodsmentioning

confidence: 99%

Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation with Hydroxypropyl-β-Cyclodextrin

et al. 2020

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Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the Biopharmaceutical Classification System) as a model drug. At a low concentration of Gly drug precipitation occurred while, for higher concentrations of Gly, a significant deterioration of mucoadhesive and mechanical properties was observed. One possible way to overcome all these problems could be the addition of hydroxypropyl-β-cyclodextrin (HP-β-CD) to the GG-Gly formulation as a drug-precipitation inhibitor. In this work the effect of cyclodextrin addition on the mechanical, mucoadhesive, swelling and release properties of GG-Gly films was investigated. In-vitro drug release studies were carried out using the paddle type dissolution apparatus (USP II) and the millifluidic flow-through device (MFTD). A moving-boundary model for swelling dynamics and release in USP II is proposed to estimate the effective diffusivity of the solvent, HP-β-CD, fluconazole and complex fluconazole/HP-β-CD in the swelling film. Experimental results, supported by theoretical modeling, confirmed that gellan gum-low glycerol thin films including HP-β-CD represent a suitable formulation for fluconazole drug delivery. A sustained release was observed when GG-Gly film is loaded with a preformed complex fluconazole/HP-β-CD.

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“…The inclusion complex between fluconazole and HP-

-CD was prepared with 1:1 molar ratio by the kneading method [ 27 ]. Equimolar amounts of the two components were ground in a mortar until a homogeneous mixture was obtained.…”

Section: Materials and Methodsmentioning

confidence: 99%