Rhein incorporated silk fibroin hydrogels with antibacterial and anti-inflammatory efficacy to promote healing of bacteria-infected burn wounds

Yin, Chuanjin; Han, Xiangsheng; Lu, Qingyang; Qi, Xueju; Guo, Chenglin; Wu, Xiaochen

doi:10.1016/j.ijbiomac.2021.12.156

Cited by 41 publications

(27 citation statements)

References 30 publications

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“…In order to prevent bacterial infections, the scientific community is currently focused on developing advanced dressings that can exhibit great protection against certain pathogens [53]. Yin et al, (2022) developed SF-based hydrogels and incorporated rhein into its structure, due to the fact that rhein possesses certain antibacterial and anti-inflammatory properties. After developing the target biomaterial, the authors determined the hydrogel biocompatibility by evaluating the hemolysis ratio observed after the blood was exposed to the hydrogel for 1 h. Their results showed favorable biocompatibility.…”

Section: Biocompatibilitymentioning

confidence: 99%

“…After developing the target biomaterial, the authors determined the hydrogel biocompatibility by evaluating the hemolysis ratio observed after the blood was exposed to the hydrogel for 1 h. Their results showed favorable biocompatibility. Furthermore, the authors used mice as an animal model to demonstrate in vivo the protective activity against infections, thus highlighting the feasibility of using SF-based dressings for accelerated tissue healing [ 54 ].…”

Section: Sf Key Propertiesmentioning

confidence: 99%

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The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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Silk fibroin (SF) is a natural protein (biopolymer) extracted from the cocoons of Bombyx mori L. (silkworm). It has many properties of interest in the field of biotechnology, the most important being biodegradability, biocompatibility and robust mechanical strength with high tensile strength. SF is usually dissolved in water-based solvents and can be easily reconstructed into a variety of material formats, including films, mats, hydrogels, and sponges, by various fabrication techniques (spin coating, electrospinning, freeze-drying, and physical or chemical crosslinking). Furthermore, SF is a feasible material used in many biomedical applications, including tissue engineering (3D scaffolds, wounds dressing), cancer therapy (mimicking the tumor microenvironment), controlled drug delivery (SF-based complexes), and bone, eye and skin regeneration. In this review, we describe the structure, composition, general properties, and structure–properties relationship of SF. In addition, the main methods used for ecological extraction and processing of SF that make it a green material are discussed. Lastly, technological advances in the use of SF-based materials are addressed, especially in healthcare applications such as tissue engineering and cancer therapeutics.

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Section: Biocompatibilitymentioning

confidence: 99%

Section: Sf Key Propertiesmentioning

confidence: 99%

The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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“…These motifs constitute the crystallinity domain of SF, while other amino acids with larger side chains constitute the amorphous domain [ 9 , 10 ]. Due to its excellent mechanical properties [ 11 ] and biocompatibility, with no immunogenicity or toxic side effects, SF fiber has received attention recently in research on the application and development of biomaterials, for example, dye adsorption material [ 12 ], antibacterial material [ 13 ], conductive material [ 14 , 15 ], and especially materials that are suitable for medical tissue engineering, drug-carrying composite materials [ 16 ], and bone tissue engineering scaffold [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Silk Protein Composite Bioinks and Their 3D Scaffolds and In Vitro Characterization

Li¹,

Zhao²,

Zhang³

2022

IJMS

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This paper describes the use of silk protein, including fibroin and sericin, from an alkaline solution of Ca(OH)2 for the clean degumming of silk, which is neutralized by sulfuric acid to create calcium salt precipitation. The whole sericin (WS) can not only be recycled, but completely degummed silk fibroin (SF) is also obtained in this process. The inner layers of sericin (ILS) were also prepared from the degummed silk in boiling water by 120 °C water treatment. When the three silk proteins (SPs) were individually grafted with glycidyl methacrylate (GMA), three grafted silk proteins (G-SF, G-WS, G-ILS) were obtained. After adding I2959 (a photoinitiator), the SP bioinks were prepared with phosphate buffer (PBS) and subsequently bioprinted into various SP scaffolds with a 3D network structure. The compressive strength of the SF/ILS (20%) scaffold added to G-ILS was 45% higher than that of the SF scaffold alone. The thermal decomposition temperatures of the SF/WS (10%) and SF/ILS (20%) scaffolds, mainly composed of a β-sheet structures, were 3 °C and 2 °C higher than that of the SF scaffold alone, respectively. The swelling properties and resistance to protease hydrolysis of the SP scaffolds containing sericin were improved. The bovine insulin release rates reached 61% and 56% after 5 days. The L929 cells adhered, stretched, and proliferated well on the SP composite scaffold. Thus, the SP bioinks obtained could be used to print different types of SP composite scaffolds adapted to a variety of applications, including cells, drugs, tissues, etc. The techniques described here provide potential new applications for the recycling and utilization of sericin, which is a waste product of silk processing.

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“…Multifunctional composite hydrogels are ideal wound dressing materials because of their multifunctional properties. The advanced composite hydrogels can control body fluid, moist environment, accelerate healing, reduce inflammation, and hinder bacterial growth by being biocompatible ( Yin et al, 2022 ). Composite hydrogels are multifunctional biomaterials made up of a variety of natural and synthetic polymers as well as fillers.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Arabinoxylan-functionalized-Graphene Oxide Based Composite Hydrogel for Skin Tissue Engineering

Khan

Razak

Hassan

et al. 2022

Front. Bioeng. Biotechnol.

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Wound healing is an important physiological process involving a series of cellular and molecular developments. A multifunctional hydrogel that prevents infection and promotes wound healing has great significance for wound healing applications in biomedical engineering. We have functionalized arabinoxylan and graphene oxide (GO) using the hydrothermal method, through cross-linking GO-arabinoxylan and polyvinyl alcohol (PVA) with tetraethyl orthosilicate (TEOS) to get multifunctional composite hydrogels. These composite hydrogels were characterized by FTIR, SEM, water contact angle, and mechanical testing to determine structural, morphological, wetting, and mechanical behavior, respectively. Swelling and biodegradation were also conducted in different media. The enhanced antibacterial activities were observed against different bacterial strains (E. coli, S. aureus, and P. aeruginosa); anticancer activities and biocompatibility assays were found effective against U-87 and MC3T3-E1 cell lines due to the synergic effect of hydrogels. In vivo activities were conducted using a mouse full-thickness skin model, and accelerated wound healing was found without any major inflammation within 7 days with improved vascularization. From the results, these composite hydrogels might be potential wound dressing materials for biomedical applications.

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Rhein incorporated silk fibroin hydrogels with antibacterial and anti-inflammatory efficacy to promote healing of bacteria-infected burn wounds

Cited by 41 publications

References 30 publications

The Contribution of Silk Fibroin in Biomedical Engineering

The Contribution of Silk Fibroin in Biomedical Engineering

Silk Protein Composite Bioinks and Their 3D Scaffolds and In Vitro Characterization

Multifunctional Arabinoxylan-functionalized-Graphene Oxide Based Composite Hydrogel for Skin Tissue Engineering

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