Spectroscopic and structural studies of the Schiff base 3-methoxy-N-salicylidene-o-amino phenol complexes with some transition metal ions and their antibacterial, antifungal activities

Abo-Aly, M.M.; Salem, A.; Sayed, M. A.; Aziz, Ayman A. Abdel

doi:10.1016/j.saa.2014.09.122

Cited by 78 publications

(34 citation statements)

References 32 publications

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“…Proof of the type of bonding type of H 2 L with the metal ions was also confirmed by recording their 1 H NMR spectra in DMSO‐ d 6 and in the deutrated solvent . In the spectrum of H 2 L a singlet peak appears at 5.68 ppm (s, 2H, COOH carboxylic).…”

Section: Resultsmentioning

confidence: 83%

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Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Mahmoud

Deghadi

Mohamed

2016

Applied Organom Chemis

118

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A novel Schiff base ligand (H2L) was prepared through condensation of 2,6‐diaminopyridine and o‐benzoylbenzoic acid in a 1:2 ratio. This Schiff base ligand was characterized using elemental and spectroscopic analyses. A new series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal complexes of H2L were prepared and characterized using elemental analysis, spectroscopy (1H NMR, mass, UV–visible, Fourier transform infrared, electron spin resonance), magnetic susceptibility, molar conductivity, X‐ray powder diffraction and thermal analysis. The complexes are found to have trigonal bipyramidal geometry except Cr(III), Mn(II) and Fe(III) complexes which have octahedral geometry based on magnetic moment and solid reflectance measurements. The infrared spectral studies reveal that H2L behaves as a neutral bidentate ligand and coordinates to the metal ions via the two azomethine nitrogens. 1H NMR spectra confirm the non‐involvement of the carboxylic COOH proton in complex formation. The presence of water molecules in all reported complexes is supported by thermogravimetric studies. Kinetic and thermodynamic parameters were determined using Coats–Redfern and Horowitz–Metzger equations. The synthesized ligand and its complexes were screened for antimicrobial activities against two Gram‐positive bacteria (Bacillus subtilis and Staphylococcus aureus), two Gram‐negative bacteria (Escherichia coli and Neisseria gonorrhoeae) and one fungus (Candida albicans). Anticancer activities of the ligand and its metal complexes against human breast cancer cell line (MCF7) were investigated. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 83%

“…The coordination of the azomethine nitrogen is supported by the appearance of a new metal–ligand weak band at 458–489 cm −1 due to ν(M‐N) …”

Section: Resultsmentioning

confidence: 99%

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Mahmoud

Deghadi

Mohamed

2016

Applied Organom Chemis

118

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“…The measured 1 H NMR spectroscopic data of ligands and their complexes in DMSO‐ d 6 , along with the corresponding assignments, are shown in Figure . The azomethine group (HCN–) of the H 2 L ligand gives a singlet at δ 6.52.…”

Section: Resultsmentioning

confidence: 99%

Spectroscopic, thermal analysis, and nematicidal evaluation of new mixed ligand complexes of bidentate Schiff base and 1,10 phenanthroline with some transition metals

El‐Attar

2018

J Chinese Chemical Soc

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Mononuclear Co(II), Cu(II), Y(III), Zr(IV), La(III), and U(VI) complexes of 2‐[(2‐hydroxybenzylidene)‐amino]‐benzoic acid (H2L) ligand in presence of 1,10‐phenanthroline (Phen) were synthesized and characterized by elemental analysis, spectroscopic techniques (IR, UV–vis, and 1H‐NMR), X‐ray powder diffraction and magnetic measurements. The results prove that H2L acts with the mentioned metal salts as a bidentate ON donor ligand and Phen as an NN donor ligand. The calculated bond length and force constant F(UO) in the uranyl complex are 1.732 Å and 708.90 nM−1, respectively. The electronic spectra and the magnetic susceptibility data support the octahedral geometry for the mononuclear Co(II), Y(III), Zr(IV), La(III), and U(VI) complexes and square‐pyramidal geometry for the Cu(II) complex. Thermogravimetric analysis was performed to determine the thermal stability of the synthesized compounds. The kinetic parameters, that is, the activation energy (E*), pre‐exponential factor (A), entropy of activation (ΔS*), enthalpy of activation (ΔH*) and free energy of activation (ΔG*), of the thermal degradation process were evaluated using Coats–Redfern (C–R) and Horowitz–Metzger (H–M) methods for all the complexes, and the best fit results could be obtained. In the present work, all the synthesized complexes showed nematicidal activity against the root knot nematode (Meloidgyne javanica) by inhibiting egg hatching and causing larval mortality of second‐stage juveniles.

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“…This is mainly due to their ease of preparation, good solubility in common solvents, structural diversities, magnetic, spectral, redox, and catalytic properties [3][4][5][6][7][8]. Transition metal complexes contain oxygen and nitrogen donor Schiff base ligands, which can be modified by choosing the appropriate amine precursors and the ring may serve in coordination field [9].…”

Section: Introductionmentioning

confidence: 99%

Elaborated studies on nano-sized homo-binuclear Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) complexes derived from N2O2 Schiff base, thermal, molecular modeling, drug-likeness, and spectral

Shah

Abou‐Melha

Saad

et al. 2015

J Therm Anal Calorim

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A series of new homo-binuclear nano Mn(II), Fe (III), Co(II), Ni(II), and Cu(II) complexes were synthesized using a Schiff base ligand derived by condensation of p-phenylenediamine with 2-hydroxy-1-naphthaldehyde. The prepared complexes were characterized using elemental, thermal analyses, FTIR, 1 HNMR, 13 CNMR, UV-Vis, XRD, SEM, molar conductance, and magnetic moment measurements. FTIR spectral studies revealed the interaction of the ligand as bi-negative tetra-dentate towards Mn(II) and Fe(III) atoms, whereas the ligand molecule coordinates in neutral tetra-dentate mode towards Co(II), Ni(II), and Cu (II) ions. The geometries proposed are mainly octahedral configuration surrounds the central atoms referring to the electronic spectral data and magnetic measurements. The calculations abstracted from XRD patterns propose the nano-sized complexes. The SEM images show the nanosized appearance of the particles except for the Ni(II)-complex. Thermo-gravimetric analysis was used to ensure the nature of the presence of solvent molecules attaching to the complexes. Molecular modeling was performed to assert the structural formula proposed for the ligand and some of its complexes. Also, drug-likeness was theoretically estimated to display the probable biological activity of the free ligand through a theoretical comparison with known drugs.

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Spectroscopic and structural studies of the Schiff base 3-methoxy-N-salicylidene-o-amino phenol complexes with some transition metal ions and their antibacterial, antifungal activities

Cited by 78 publications

References 32 publications

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Spectroscopic, thermal analysis, and nematicidal evaluation of new mixed ligand complexes of bidentate Schiff base and 1,10 phenanthroline with some transition metals

Elaborated studies on nano-sized homo-binuclear Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) complexes derived from N2O2 Schiff base, thermal, molecular modeling, drug-likeness, and spectral

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