Spectroscopic and photoacoustic characterization of encapsulated iron oxide super-paramagnetic nanoparticles as a new multiplatform contrast agent

Armanetti, Paolo; Flori, Alessandra; Avigo, Cinzia; Conti, Luca; Valtancoli, Barbara; Petroni, Debora; Doumett, Saer; Cappiello, Laura; Ravagli, Costanza; Baldi, Giovanni; Bencini, Alessandro; Menichetti, Luca

doi:10.1016/j.saa.2018.03.025

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…In the presence of a magnetic field, they exhibit magnetic properties; this effect ceases totally when the magnetic field is removed. These characteristics make MBs very useful for many different applications [86], including purification processes in bioanalytics; instead of centrifugation, filtration, or precipitation procedures, a simple magnet is sufficient. MB-assisted electrochemical biosensors pave the way for fast and handy protocols by decreasing electrode biofouling [87,88].…”

Section: Peptides As Substrate and Signal Development Agents In Catalytic Biosensorsmentioning

confidence: 99%

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

et al. 2021

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Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described.

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Section: Peptides As Substrate and Signal Development Agents In Catalytic Biosensorsmentioning

confidence: 99%

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

et al. 2021

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“…Iron oxide and gold nanoparticle systems have shown an excellent propensity for photoacoustic nanoprobes, producing detectable acoustic signal from a range of optical excitation wavelengths, including in the NIR spectrum. These materials are also widespread in research due to their good biocompatibility and varying functionalities and are well developed as commercially available products for biomedical usage [ 137 , 138 ]. A number of Iron Oxide Nanoprobes (IONPs) have been developed as photoacoustic molecular imaging agents, and they target human epidermal growth factor receptor 2 (HER2), which is a protein overexpressed in various ovarian cancer subtypes [ 139 , 140 ].…”

Section: Recent Developments Of Nanoparticles For Ovarian Cancer Diagnosticsmentioning

confidence: 99%

The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

et al. 2021

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Ovarian cancer remains as one of the most lethal gynecological cancers to date, with major challenges associated with screening, diagnosis and treatment of the disease and an urgent need for new technologies that can meet these challenges. Nanomaterials provide new opportunities in diagnosis and therapeutic management of many different types of cancers. In this review, we highlight recent promising developments of nanoparticles designed specifically for the detection or imaging of ovarian cancer that have reached the preclinical stage of development. This includes contrast agents, molecular imaging agents and intraoperative aids that have been designed for integration into standard imaging procedures. While numerous nanoparticle systems have been developed for ovarian cancer detection and imaging, specific design criteria governing nanomaterial targeting, biodistribution and clearance from the peritoneal cavity remain key challenges that need to be overcome before these promising tools can accomplish significant breakthroughs into the clinical setting.

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“…The mechanism of photo-acoustic imaging relies on the excitation of a tissue with a nanosecond pulsed laser of 680-970 nm emission wavelength, 10 Hz frequency, and 10-100 mJ cm À2 power, resulting in a slight temperature increase and thermoelastic expansion of the tissue, which further generates an acoustic wave that provides an image of tissue following detection and processing of the signal by an echograph of typical ultrasound frequency 5-50 MHz. [43][44][45] Chromophores such as melanin and hemoglobin that are strong optical absorbers can act as intrinsic PAI contrast agents. However, in some cases they are not available, e.g.…”

Section: Photo-acoustic Imaging (Pai)mentioning

confidence: 99%

Iron oxide nanoparticles as multimodal imaging tools

Alphandéry

2019

RSC Adv.

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Spectroscopic and photoacoustic characterization of encapsulated iron oxide super-paramagnetic nanoparticles as a new multiplatform contrast agent

Cited by 14 publications

References 22 publications

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

Iron oxide nanoparticles as multimodal imaging tools

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