Spectroscopic and microbiological characterization of labdane diterpene 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione isolated from the stems of Croton jacobinensis

Bernardino, A.C.S.S.; Teixeira, Alexandre Magno Rodrigues; Menezes, Jane Eire Silva Alencar de; Pinto, Cleonilda Claita Carneiro; Santos, Hélcio Silva dos; Freire, Paulo; Coutinho, Henrique Douglas Melo; Sena, Diniz M.; Bandeira, Paulo Nogueira; Braz-Filho, Raimundo

doi:10.1016/j.molstruc.2017.06.084

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…Their structures, molecular formula, names, corresponding sources, and references are collected in Figure 5 and Table 5 12 new labdanes ( 228 , 249 – 259 ) were isolated from C . laui [ 21 , 76 , 77 ]. From the leaves of C .…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Among them, crotonlaevins A–B ( 233 , 234 ), represents rare labdanes with a dodecahydronaphtho [1,2-c] furan moiety [ 79 ]. Three new labdane diterpenoids ( 260 – 262 ) were found from C. jacobinensis [ 77 ] and C. decalvatus [ 80 ], respectively. Bicrotonol A ( 263 ), one dimeric labdane-type diterpenoid, was obtained from the roots of C .…”

Section: Chemical Constituentsmentioning

confidence: 99%

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Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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The genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018. A total of 399 new compounds, including 339 diterpenoids, were reported. Diterpenoids are characteristic components of the Croton species. These isolated compounds exhibited a broad spectrum of bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting properties. The present review provides a significant clue for further research of the chemical constituents from the Croton species as potential medicines.

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Section: Chemical Constituentsmentioning

confidence: 99%

Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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“…An example of the 49 Syn-NPs-CAAs for EC is the methanolic extracts of edible plants Psidium guajava L., Persea americana Mill., Camellia sinensis L., Mangifera indica L., Coula edulis Baill., and Citrus sinensis L. [93]. Other plant extracts inhibited EC growth with focus on foodborne, hospital acquired infections and veterinary [117, 86, 29, 118, 119, 120, 30, 121, 122, 27, 123, 124, 100, 125, 126, 127, 128, 129, 92, 130, 48, 131, 132, 93, 133, 134, 135, 136, 137, 138, 99, 139, 93, 140, 141, 142, 143, 144, 95, 89, 145, 146, 147, 78, 80, 81, 82, 93].…”

Section: Resultsmentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

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Background: Opportunistic resistant bacteria are health and economically relevant in the health care systems and in industries worldwide, especially in the so-called resistant bacteria era (RBE). Enhancing the activity of commercially available antibiotics (CAAs) with di erent types of natural products (NPs) is a successful antimicrobial strategy, for instance the amoxicillin and clavulanate mixture. Objective: To nd research trends in this eld during 2015-2020 and to detect potential drug hits with potential to diversify formulations and materials design that can be useful to manage the RBE. Systematic review results: It yielded 190 reports of synergistic e ects of CAAs and NPs. The analyzed variables were: a) natural products origin: plant family, genera, secondary metabolite type; b) strains: +/- Gram, genera, most frequent species, application eld; and c) CAAs: family, most frequent CAAs. The families with potential to have more bioactive species were Apocynaceae, Rubiaceae, Euphorbiaceae (Isbio factor). Lonicera had the highest reports amount. Polyphenols and avonoids were the majority of pure NPs tested. Several potential drug hits for antibiotic activity enhancement at synergistic level were identi ed together with potential mechanisms of action: berberine (drug e ux inhibitor{DEI, bio lm inhibitor{BI), curcumin (BI), essential oils (BI), 3-o-metyl-butylgallato (inhibition of fatty acid saturation), among others. About the half of the tested strains were gram positive, being Methicillin Resistant Staphylococcus aureus (MRSA) the most frequently tested. Escherichia coli was the gram negative strain most frequently reported, including enterotoxigenic and extended spectrum beta-lactamases producers. The growth of other foodborne genera strains, such as Listeria and Salmonella, were also inhibited. Aminoglycosides were the family most reported, with gentamicin as the most commonly studied. Conclusions: NPs as either as plant extracts from a variety of families, or as puri ed compounds specially avonoids and polyphenols, have shown e ective results to enhance the antibiotic activity of CAAs against gram positive and negative strains relevant to HC and FI. Their mechanisms of action are starting to be determined, as the case EPIs and BIs. Further research is needed to achieve co-formulations and materials design useful for those elds, that can certainly be positively impacted by pursuing this strategy.

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“…Os estudos realizados com espécies de Croton têm mostrado uma alta diversidade de estruturas químicas: terpenos (KAWAKAMI et al, 2015;CHAVEZ et al, 2013;PIZZOLATTI et al, 2013;ALDAHAER et al, 2017;QIU et al, 2018;MORA et al,2011;MATEU et al, 2012;PEREIRA et al, 2012;BERNARDINO et al, 2017;PALMEIRA et al, 2006;TENE et al, 2009), alcalóides e flavonóides também são comuns no gênero (ARAUJO-JUNIOR et al, 2004;SUÁREZ et al, 2004).…”

Section: Introductionunclassified

Avaliação Da Segurança Não Clínica Do Triterpeno Ácido Acetil Aleuritólico (Aaa) Isolado De Croton Zehntneri Em Zebrafish (Danio Rerio) Adulto

Bezerra

Ferreira

Silva

et al. 2020

BJD

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Este trabalho busca a avaliação da segurança não clínica do triterpeno AAA frente aos ensaios com zebrafish (Danio rerio) adulto. O triterpeno AAA foi isolado da raiz de Croton zehntneri. Soluções desta substância foram preparadas com salina 0,9 %, nas concentrações de (4,0 mg/kg ou 12 mg/kg ou 40 mg/kg; 20 μL i.p) e submetidas ao teste de toxicidade aguda frente ao modelo zebrafish. As mesmas doses foram investigadas quanto ao possível efeito ansiolítico, através do teste de campo aberto. As três dosagens de AAA testadas não foram tóxicas nos zebrafish e não reduziram a atividade locomotora do animal, tendo assim uma possível ação nociceptiva pois a amostra não alterou a atividade locomotora dos animais.

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Spectroscopic and microbiological characterization of labdane diterpene 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione isolated from the stems of Croton jacobinensis

Cited by 13 publications

References 29 publications

Chemical Constituents from Croton Species and Their Biological Activities

Chemical Constituents from Croton Species and Their Biological Activities

Perspectives on the enhancement of commercially available antibiotics by natural products

Avaliação Da Segurança Não Clínica Do Triterpeno Ácido Acetil Aleuritólico (Aaa) Isolado De Croton Zehntneri Em Zebrafish (Danio Rerio) Adulto

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