Spectroscopic analysis of the interaction between chromium (III) and apoovotransferrin

Li, Yingqi; Liu, Bin; Yang, Binsheng

doi:10.1016/j.jlumin.2010.07.015

Cited by 11 publications

(1 citation statement)

References 22 publications

(30 reference statements)

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“…54,182,193 Another limitation of all these analytical techniques is their poor sensitivities (require mM concentrations of V), 182 although computer modelling can be used to extrapolate the results to biologically relevant V concentrations (low mM range). 194,195 Early electronic and EPR spectroscopic data, 196 supported by more recent data, 197 showed that Cr(III) is capable of binding specifically to Fe(III) binding sites of transferrin. Hence, this was assumed to act as the main Cr(III) transport protein, at a time it was considered as essential.…”

Section: Mammalian Metabolism and Speciation Of Anti-diabetic Metal C...mentioning

confidence: 77%

Metal-based anti-diabetic drugs: advances and challenges

2011

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The current status and likely future directions of complexes of V(V/IV), Cr(III), Mo(VI), W(VI), Zn(II), Cu(II), and Mn(III) as potential oral drugs against type 2 diabetes are reviewed. We propose a unified model of extra- and intracellular mechanisms of anti-diabetic efficacies of V(V/IV), Mo(VI), W(VI), and Cr(III), centred on high-oxidation-state oxido/peroxido species that inhibit protein tyrosine phosphatases (PTPs) involved in insulin signalling. The postulated oxidative mechanism of anti-diabetic activity of Cr(III) via carcinogenic Cr(VI/V) (which adds to safety concerns) is consistent with recent clinical trials on Cr(III) picolinate, where activity was apparent only in patients with poorly controlled diabetes (high oxidative stress), and the correlation between the anti-diabetic activities and ease of oxidation of Cr(III) supplements and their metabolites in vivo. Zn(II) and Cu(II) anti-diabetics act via different mechanisms and are unlikely to be used as specific anti-diabetics due to their diverse and unpredictable biological activities. Hence, future research directions are likely to centre on enhancing the bioavailability and selectivity of V(V/IV), Mo(VI), or W(VI) drugs. The strategy of potentiating circulating insulin with metal ions has distinct therapeutic advantages over interventions that stimulate the release of more insulin, or use insulin mimetics, because of many adverse side-effects of increased levels of insulin, including increased risks of cancer and cardiovascular diseases.

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Section: Mammalian Metabolism and Speciation Of Anti-diabetic Metal C...mentioning

confidence: 77%

Metal-based anti-diabetic drugs: advances and challenges

2011

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Fluorescence Spectroscopy in Food Analysis

Albani

2012

Encyclopedia of Analytical Chemistry

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Food is vital for life, thus it is very important to know how to maintain its quality and thus to detect and analyse all components interfering with food quality. This article describes application of spectrofluorometry combined with high‐performance liquid chromatography (HPLC) in food analysis. Spectrofluorometry allows measuring structural changes in food proteins, whereas HPLC combined with fluorescence helps to study toxins, pathogenic microbes, heating effects, fat oxidation, vitamins, additives, amino acids, and enzyme activity in food.

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The absorption and transport of chromium in the body

Vincent

Edwards

2019

The Nutritional Biochemistry of Chromium (III)

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Spectroscopic analysis of the interaction between chromium (III) and apoovotransferrin

Cited by 11 publications

References 22 publications

Metal-based anti-diabetic drugs: advances and challenges

Metal-based anti-diabetic drugs: advances and challenges

Fluorescence Spectroscopy in Food Analysis

The absorption and transport of chromium in the body

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