The absorption and transport of chromium in the body

Vincent, John B.; Edwards, Kyle

doi:10.1016/b978-0-444-64121-2.00004-0

Cited by 3 publications

(3 citation statements)

References 115 publications

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“…In fact, chromium (VI) is more absorbed in the small intestine than chromium (III) because of the structural similarity between chromium VI and sulphates. In humans, the adsorption of chromium III does not exceed 1%, whereas that of chromium VI can be around 10% [48,49]. Moreover, once absorbed, chromium VI represents the real danger for the human body.…”

Section: Chromiummentioning

confidence: 99%

The Toxicity of Environmental Pollutants

Ismaël¹,

Sorho²

2022

The Toxicity of Environmental Pollutants

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In view of the growing threat of trace metals to human health, this work set itself the objective of documenting the toxicity of the trace metals most in contact with humans on human health through food. Thus, this study revealed that organic matter, pH and CEC are the main soil parameters that influence the passage of trace metals from soil to plants. The study also revealed that agriculture, industry and road traffic contribute greatly to the input of trace metals into the environment. Regarding the mechanisms of toxicity, the study showed that chromium VI and copper manifested their toxicity by the formation of free radicals after reduction, those of zinc, nickel, manganese and nickel resulting from the disfunctioning of homeostasis. The study showed that lead caused toxic effects by replacing certain cations such as Ca2+, Mg2+, Fe2+, Na+ which have important functions in the cell. Cadmium expresses its toxicity by binding to albumin, thus altering the homeostasis of metals such as calcium. All these mechanisms have revealed both acute and chronic toxic effects.

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Section: Chromiummentioning

confidence: 99%

The Toxicity of Environmental Pollutants

Ismaël¹,

Sorho²

2022

The Toxicity of Environmental Pollutants

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“…In systematic exposure, chromium mostly enter the human body via oral consumption of certain chromium sources such as food or food supplement [29], foodstuff [30], and drinking water [31] or from applications of chromium-based implants [32]. In the digestive system, most of Cr(III) consumed are excreted to feces and some of it (~2%) is absorbed by epithelial cells covering the stomach and enterocytes covering the intestines through passive absorption (diffusion) [33]. This absorption was affected (increased or decreased) by the presence of various ligand such as amino acids, vitamins, carbohydrates, plasma proteins, certain metals, and other chelating agents [34].…”

Section: Source and Exposure Route Of Chromium In The Skinmentioning

confidence: 99%

“…After the absorption, Cr(III) complex would be accumulated inside the cells or actively transported to the blood stream by still an Dermatologic Toxicities and Biological Activities of Chromium DOI: http://dx.doi.org/10.5772/intechopen.90347 unknown transporter. Cr(III) ions then bound to transferrin (siderophilin) or other plasma proteins in the blood stream and travel to the whole body [33,34].…”

Section: Source and Exposure Route Of Chromium In The Skinmentioning

confidence: 99%

Dermatologic Toxicities and Biological Activities of Chromium

Jumina¹,

Harizal²

2021

Trace Metals in the Environment - New Approaches and Recent Advances

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Chromium is a versatile metal with various industrial applications and biological activities. However, as a transition metal, this element forms several species, i.e. oxidation states of −4 to +6, with different degrees of toxicities that affect ecosystems and organisms including human beings. The skin is the outermost organ that usually interacts directly with chromium species in nature. These contact and interaction induce the formation of several acute and chronic negative effects including contact dermatitis, skin cancer, allergy, etc. In this chapter, toxicity and biological activity of several chromium species, such as chromium zero-valent, trivalent, hexavalent, will be reviewed to obtain better comprehension in chromium toxicity. Sources and routes of exposure, toxicity and possible treatment, and biological activity on the skin are arranged and explained systematically.

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