Spectrophotometric study of stability constants of cimetidine–Ni(II) complex at different temperatures

Hydrothermal synthesis of zeolite composite membranes and crystals as potential vectors for drug-delivering biomaterials

“…In particular, in the crystalline structures resolved by single crystal X-ray method, famotidine was found to be coordinated to Co(III), Cu(II) [44] and Ni(II) [45,46] like a tetradentate ligand, although both complexes differ in one of nitrogen donors involved in the coordination. In solution phase, this drug is an excellent chelating agent for Pd(II) and Pt(II): a mononuclear Pd-famotidine complex with cisplatin-like geometry (where famotidine acts like a bidentate chelate agent) and a dinuclear Pt-famotidine complex (where famotidine acts like a tridentate chelate agent) were synthesized and characterized [49][50][51].…”

“…An increased pH value produce the formation of two complexes formally written as Cu(LH)H À1 and Cu(LH) 2 H À2 (because this pH leads to release of one or two protons originating from the thiazole ring nitrogen) and having their concentration maximum centered at pH around 6.5 and 7.4, respectively. Moreover, famotidine is a strong ligand for copper(II) [44] with stability constants for CuL and CuL 2 complexes equal to 7.27 and 14.03, respectively. Although this drug has a complicated set of potential donors the metal ion coordination is not able to change some conformational features, which could be an biologically important factor [52].…”

“…Thus, both species could exists and the drug adsorption percentage reveals a minimum value for all sample, in this range of pH range, because the electrostatic interactions with zeolite materials decrease. In solution phase, famotidine is an efficient chelating agent for different transition metals, and its complexes with Cu(II) [40][41][42][43][44], Ni(II) [40,[45][46][47] and Co(III) [48] have been recently synthesized and characterized. It offers various potential coordination sites such as the guanidine, thiazole nitrogen, thioether sulphur and amine group nitrogen, but the peculiarities of the transition metal ions as well as the experimental conditions used can influence the type of drug coordination.…”

A simple and effective method for determination of the antithyroid drug carbimazole using ruthenium trichloride

“…17 The color intensity and absorbance were constant for a maximum of 12 h. The stability constant can be calculated from the following equation:…”

Conductometry, spectrophotometry and mass spectrometric investigation of Mg(II) and Ca(II) complexes with an antiretroviral drug, zidovudine

“…This equation is widely used as the only assumption for this method is that there can be at the most only two absorbing species which obey the Beer's Law. For comparison purpose, the formation constant of the complexes was also evaluated by two other methods, the Job's method and mole ratio method, as studied previously for drug-metal ion complexation [31,32]. For Job's method the following equation was used,…”