Hydrothermal synthesis of zeolite composite membranes and crystals as potential vectors for drug-delivering biomaterials

Tavolaro, Adalgisa; Riccio, Ilaria Iolanda; Tavolaro, Palmira

doi:10.1016/j.micromeso.2012.04.024

Cited by 25 publications

(14 citation statements)

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“…Nevertheless, there are not many works studying the relationship between biologically lively molecules and zeolite synthetic as the subsidiary therapy of hematologic disorder [47]. Recently, the zeolite membranes and crystals have been hydrothermally synthesized as biomaterials for drug-delivering [48]. The investigation results showed that the desorption manners of B-silicate is exceptional and has the main entanglement for biomedical application.…”

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

“…Famotidine adsorption on B-silicate, and ZSM-5 nano zeolite crystal : (a) adsorption isotherms at pH 7.8 and (b) pH effect on famotidine adsorbed [48] Zeolite for Bone Implant…”

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

“…The porous structure and powder form is the zeolite properties which are the main consideration in its development, however, the corrosion resistance of metals directly influenced by synthesis of the zeolite coating layer on the metal surface [29,30]. Bedi et al [48] have shown that the high silica zeolite (HSZ) MFI can be an alternative material in corrosion protecting Ti6Al4V and hinder the liberation of cytotoxic ions. The MFI zeolite coating layer has been revealing to have excellent resistance to corrosion and the eminent adhesion for a variety of metallic substrate like titanium-based alloy.…”

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

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Zeolite-based biomaterials for biomedical application: A review

Purnomo

Setyarini

Sulistyaningsih

2018

AIP Conference Proceedings

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Abstract. This review focuses on the latest reports of the use of zeolites, natural as well as synthetic, as biomedical materials. Discussion on biocompatibility, non-toxicity, zeolite for drug delivery materials, zeolite for bone implants and implant coatings, and the mechanical properties of polymer-zeolite composites are included. The section on the interaction between body tissues and zeolite-based biomaterials focuses on their biocompatibility, non-toxicity, and bioactivity. The next section concerns drug delivering biomaterials. Including delivery of a controlled drug, ionic removal, and synthesized drug delivering materials. The final section concern bone graft substitutes and implant-coating to improve corrosion resistance and osteointegration. The implant material system discussed in a further section is an investigation of the mechanical properties of high-density polyethylene(HDPE)-zeolite composites developed as skull bone implant materials.

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Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

“…Famotidine adsorption on B-silicate, and ZSM-5 nano zeolite crystal : (a) adsorption isotherms at pH 7.8 and (b) pH effect on famotidine adsorbed [48] Zeolite for Bone Implant…”

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

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Zeolite-based biomaterials for biomedical application: A review

Purnomo

Setyarini

Sulistyaningsih

2018

AIP Conference Proceedings

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“…ZSM‐5 zeolites are aluminosilicate molecular sieves with pores of molecular dimensions, which have been widely used in applications such as catalysis, ion exchange, adsorption, and separations . Recently, researchers have found that zeolites exhibit non‐toxicity and good biocompatibility, so they have great potentials for biomedical applications . Bedi et al have synthesized zeolite mordenite framework inverted (MFI) coatings on Ti6Al4V substrates.…”

Section: Introductionmentioning

confidence: 99%

“…The zeolite coatings not only prevent the release of cytotoxic Al and V ions intohuman tissue because of the high stability in solutions, but also promote thedifferentiation of human fetal osteoblasts into mature osteoblasts, and the production of a mineralized matrix at earlier times in culture, indicating the higher osteoinductive property of zeolite coatings than bare Ti6Al4V . Moreover, zeolites exhibit the ordered microporous structure and high surface area, which make them have great potentials as drug delivery systems . As compared with nonporous materials, microporous materials have the greater drug loading capacity because high doses of drugs may enter into the microporous channels.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal fabrication of ZSM‐5 zeolites: Biocompatibility, drug delivery property, and bactericidal property

et al. 2013

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The bone graft-associated infection is widely considered in orthopedic surgery, which may lead to implant failure, extensive bone debridement, and increased patient morbidity. In this study, we fabricated ZSM-5 zeolites for drug delivery systems by hydrothermal method. The structure, morphology, biocompatibility, drug delivery property, and bactericidal property of the ZSM-5 zeolites were investigated. The ZSM-5 zeolites have mordenite framework inverted-type structure and exhibit the disk-like shape with the diameter of ∼350 nm and thickness of ∼165 nm. The biocompatibility tests indicate that human bone marrow stromal cells spread out well on the surfaces of the ZSM-5 zeolites and proliferate significantly with increasing culture time. As compared with the conventional hydroxyapatite particles, the ZSM-5 zeolites possess greater drug loading efficiency and drug sustained release property because of the ordered micropores, large Brunauer-Emmett-Teller (BET) surface areas, and functional groups. For the gentamicin-loaded ZSM-5 zeolites, the sustained release of gentamicin minimizes significantly bacterial adhesion and prevents biofilm formation against Staphylococcus epidermidis. The excellent biocompatibility, drug delivery property, and bactericidal property of the ZSM-5 zeolites suggest that they have great application potentials for treating implant-associated infections.

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