Spectrophotometric microdetermination of anti-Parkinsonian and antiviral drug amantadine HCl in pure and in dosage forms

Omara, Hany A.; Amin, Alaa S.

doi:10.1016/j.arabjc.2010.06.048

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…58 Several spectrophotometric, NMR and IR studies of the amantadine hydrochloride salt (Ama·HCl) focus mostly on analytical applications of this drug molecule. 54,59–62…”

Section: Introductionmentioning

confidence: 99%

Infrared spectra and structures of protonated amantadine isomers: detection of ammonium and open-cage iminium ions

George

Dopfer

2022

Phys. Chem. Chem. Phys.

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“…58 Several spectrophotometric, NMR and IR studies of the amantadine hydrochloride salt (Ama·HCl) focus mostly on analytical applications of this drug molecule. 54,59–62…”

Section: Introductionmentioning

confidence: 99%

Infrared spectra and structures of protonated amantadine isomers: detection of ammonium and open-cage iminium ions

George

Dopfer

2022

Phys. Chem. Chem. Phys.

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“…However, in solid dosage formulations, most excipients are mainly inorganics and are chromophore‐free to absorb in the UV region. The excipients and additives usually presented in solid dosage pharmaceutical formulation are sodium lauryl sulfate, magnesium stearate, starch sodium glycolate, lactose spray dried, carboxymethylcellulose (CMC), talc, titanium dioxide, microcrystalline cellulose, hydroxypropylcellulose, and pregelanitizated starch [34]. These substances are methanol‐insolubles and free of chromophores.…”

Section: Resultsmentioning

confidence: 99%

“…The proposed method have shown the propensity of being free from interferences likely to be caused by excipients such as glucose, lactose, and starch, and/or from common degradation products compared to the HPLC method, where residual build‐ups of analytes and impurities in columns may interfere with analysis [17,34]. The amount of organic solvent consumed was significantly higher for HPLC compared to the TLC–UV method [17].…”

Section: Resultsmentioning

confidence: 99%

Simple thin layer chromatography–ultraviolet spectrophotometric method for quality assessment of binary fixed‐dose‐combinations of lamivudine/tenofovir disoproxil fumarate and lamivudine/zidovudine in tablet formulations

Vaikosen

Kashimawo

Soyinka

et al. 2020

J of Separation Science

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Antiretroviral fixed-dose-combination drugs are best assayed with high-performance liquid chromatography, or liquid chromatography-tandem mass spectrometry. However, most scientists in developing nations have no access to these expensive instruments. A more affordable quantitative technique is the use of ultraviolet-visible spectroscopy-where often the absorption spectra of these antiretrovirals are overlapping; thus complex derivative methodologies are required for quantification. A simple, rapid, and accurate thin layer chromatography-ultraviolet spectrophotometric method for the quantification of binary mixtures of lamivudine, zidovudine, and tenofovirdisoproxil-fumarate in tablet formulations was developed. Lamivudine/tenofovirdisoproxil-fumarate and lamivudine/zidovudine were extracted and separated on glass thin-layer chromatography plates. Drugs were identified in ultraviolet light at 254 nm and quantified in acidic medium using ultraviolet spectrophotometry. The retardation factors were 0.43, 0.79, and 0.81 for lamivudine, tenofovir-disoproxilfumarate, and zidovudine, respectively, with corresponding absorption maxima at 270, 260, and 265 nm. Linearity ranged from 1 to 40 µg/mL for all drugs (R = 0.9998-0.9999), while recovery studies were 95.10-102.11% and amount in formulations ranged from 97.99 ± 0.63 to 101.47 ± 2.39%. The paired t-test (n = 5) indicated no significant difference between the proposed and high-performance liquid chromatography methods, hence comparable and can be used as an alternative method in routine quality determination of antiretroviral medicines. K E Y W O R D S

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“…The liberated Fe (II) can be determined using selective chelating agents, such as 1,10-phenanthroline and 2,2bipyridyl [26]. The proposed methods are based on the formation of tris(o-phenanthroline)-iron(II) [Phen] or tris (bipyridyl)-iron(II) [Bip] chelates upon the reduction of the corresponding Fe (III) complexes with different carbapenem derivatives [21,25,[27][28][29] with maximum absorptions at 510 and 520 nm, respectively (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

New spectrophotometric microdetermination of carbapenem antibiotics derivatives in pharmaceutical formulations

Homoda

Kamel

Khaled

2016

Journal of Taibah University for Science

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A new sensitive spectrophotometric method was developed to determine three carbapenem antibiotics: imipenem, meropenem and ertapenem. The proposed method was based on the formation of the coloured tris(o-phenanthroline)-iron(II) complex (ferroin) [Phen] or Fe (II)-2,2 -bipyridyl complex [Bip] in the reaction of the tested drugs with the corresponding iron (III)-complexes in an acetate pH 4 buffer. The formed coloured complexes showed maximum absorbance at 510 and 520 nm for [Phen] and [Bip], respectively. The reaction conditions, including the pH, reagent concentration, reaction time, temperature and stability of the formed coloured species, were optimized to achieve the highest sensitivity. Linear calibration curves were obtained in the concentration ranges from 0.2 to 10, 0.5 to 10 and 0.5 to 10 g mL −1 for the aforementioned drugs in the same order. The developed method was successfully applied to determine the investigated carbapenems in their pharmaceutical formulations with average recoveries of 100.8, 99.8 and 99.4% for the Phen method and 98.9, 101.7 and 100.6% for the Bip method for imipenem, meropenem and ertapenem, respectively. A statistical comparison of the results with the reference method showed good concurrence and indicated no significant difference in accuracy or precision.

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Spectrophotometric microdetermination of anti-Parkinsonian and antiviral drug amantadine HCl in pure and in dosage forms

Cited by 12 publications

References 20 publications

Infrared spectra and structures of protonated amantadine isomers: detection of ammonium and open-cage iminium ions

Infrared spectra and structures of protonated amantadine isomers: detection of ammonium and open-cage iminium ions

Simple thin layer chromatography–ultraviolet spectrophotometric method for quality assessment of binary fixed‐dose‐combinations of lamivudine/tenofovir disoproxil fumarate and lamivudine/zidovudine in tablet formulations

New spectrophotometric microdetermination of carbapenem antibiotics derivatives in pharmaceutical formulations

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