2005
DOI: 10.1007/s00280-004-0990-z
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Abstract: The use of infusional chemotherapy, especially in an ambulatory setting, absolutely requires that the individual agents remain stable in solution at room temperature and that the drugs be compatible. Because of this, investigation of the chemical compatibilities of chemotherapeutic drug combinations given in the same infusion solution is quite important especially if the drugs are to remain in solution for long periods. Thus, the visual and chemical compatibility of irinotecan and epirubicin in the same infusi… Show more

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Cited by 8 publications
(2 citation statements)
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“…Epirubicin belongs to the anthracycline anti-tumor antibiotics, a class of chemotherapy drugs with a broad activity against a wide range of tumors, including breast and lung ones [1]. Numerous methods have been developed using high-performance liquid chromatography (HPLC) with various detectors.…”
Section: Introductionmentioning
confidence: 99%
“…Epirubicin belongs to the anthracycline anti-tumor antibiotics, a class of chemotherapy drugs with a broad activity against a wide range of tumors, including breast and lung ones [1]. Numerous methods have been developed using high-performance liquid chromatography (HPLC) with various detectors.…”
Section: Introductionmentioning
confidence: 99%
“…However, toxicity is not the only issue, since several compounds amongst these present physicochemical incompatibilities between them. This is the case for Irinotecan versus Gemcitabine and Epirubicin, and Fluorouracil versus Doxorubicin, Daunorubicin, and Cytarabine . Thus, this method is useful for the detection of cross‐contamination with these seven drugs in a centralized pharmacy unit in a hospital environment.…”
Section: Resultsmentioning
confidence: 99%