Spectrophotometric determination of tryptophan by reaction with nitrous acid

Verma, Krishna K.; Jain, Archana; Gasparič, J.

doi:10.1016/0039-9140(88)80008-0

Cited by 24 publications

(8 citation statements)

References 27 publications

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“…From the results, we concluded that the presence of excess of all concomitant compounds did not significantly influence the determination of Trp upon the experimental conditions, and the method is relatively selective for determination of the Trp in the pharmaceutical samples. On the other hand, this table indicates the high accuracy and precision of the present work as compared with those previously reported by other methods [12,15,16], which require more complicated instrumentations or time-consuming pretreatment steps.…”

Section: Voltammetric Analysis Of Pharmaceutical Synthetic Samples Bysupporting

confidence: 51%

“…So far, several analytical methods for the determination of pharmaceutical mixtures including voltammetry [2,10], HPLC [11][12][13][14], spectrofluorimetry [15], spectrophotometry [16], capillary electrophoresis [17,18], flow-injection analysis [19][20][21], gas chromatography/mass spectrometry [22], thin-layer chromatography/ fluorescence detection [23], ion exchange chromatography [24], amperometric determination [25], far-IR absorption and reflection spectra [26], ion chromatography [27], cyclic voltammetry [28] and liquid chromatography with fluorescence detection [29] have been reported. Concentration of amino acids in biological samples is low; therefore, it is necessary to use a highly sensitive method that provides determination of these analytes at subordinate concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of voltammetric biosensor for tryptophan using multi-walled carbon nanotubes

Kia

Islamnezhad

Shariati

et al. 2011

Korean J. Chem. Eng.

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Multi-walled carbon nanotubes (MWCNTs) were grown by chemical vapor deposition. The effect of the composition of carbon paste electrode on its voltammograms was evaluated in basic solution with 5.0×10 −5 M tryptophan (Trp). It was found that addition of MWCNTs to the carbon paste would generate the peak current of Trp because of its catalytic effect on the redox process. The pH strongly affects the peak potential of Trp. The best analytical response was obtained at pH 13.0. The anodic peak currents were proportional to Trp concentrations in the range of 1.0×10 −9 -1.0×10 −4 M under the optimized experimental conditions. The detection limit was 2.2×10 −10 M. The effect of potential scan rate on the peak potential and peak current of tryptophan was investigated. The correlation of the peak currents against v 1/2 (v is the scan rate) is linear, which is very similar to a diffusion-controlled process. The proposed biosensor was applied to the determination of Trp in pharmaceuticals formulations successfully.

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Section: Voltammetric Analysis Of Pharmaceutical Synthetic Samples Bysupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Preparation of voltammetric biosensor for tryptophan using multi-walled carbon nanotubes

Kia

Islamnezhad

Shariati

et al. 2011

Korean J. Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…Trp is usually determined by high-performance liquid chromatography [6], capillary electrophoresis [7], spectrophotometry [8], fluorescence [9] and chemiluminescence [10]. At the same time, Trp is an electroactive substance, which can be detected by the electrochemical method.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

Liu

Feng

et al. 2020

Nanomaterials

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In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare GCE, PVP/GCE, and GR/GCE, the oxidation peak current of Trp increased dramatically at PVP-GR/GCE. The oxidation mechanism of Trp on the PVP-GR/GCE was discussed and the experimental conditions were optimized. Under the best experimental conditions, the oxidation peak current of Trp was proportional to its concentration in the range of 0.06 µM–10.0 µM and 10.0–100.0 µM, and the limit of detection (LOD) was 0.01 µM (S/N = 3). The target modified electrode with excellent repeatability, stability and selectivity, was successfully applied to detectTrp in drugs and biological samples.

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“…It was the precursor of the neurotransmitter serotonin [1], and played an important role in brain function and related regulatory mechanisms [2][3][4]. Up to now, several analytical methods for the determination of tryptophan, including voltammetry [5,6], HPLC [7,8], spectrofluorimetry [9], spectrophotometry [10] and capillary electrophoresis [11] had been reported.…”

Section: Introductionmentioning

confidence: 99%

Flow-injection chemiluminescence determination of tryptophan through its peroxidation and epoxidation by peroxynitrous acid

Liang

Song

2005

Journal of Pharmaceutical and Biomedical Analysis

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Spectrophotometric determination of tryptophan by reaction with nitrous acid

Cited by 24 publications

References 27 publications

Preparation of voltammetric biosensor for tryptophan using multi-walled carbon nanotubes

Preparation of voltammetric biosensor for tryptophan using multi-walled carbon nanotubes

Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

Flow-injection chemiluminescence determination of tryptophan through its peroxidation and epoxidation by peroxynitrous acid

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