Spectrophotometric determination of some histamine H1-antagonists drugs in their pharmaceutical preparations

Hаssаn, Wаfаа S.; Elhenawee, Magda; Gouda, Ayman A.

doi:10.1016/j.saa.2007.03.040

Cited by 33 publications

(17 citation statements)

References 35 publications

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“…The general formula of the ternary complex denoted here as L-S-D (ligand L is the investigated drug, the second ligand S is SCN¯ and D is Mo) has been widely used in spectrophotometric analysis of some drugs like chloroquine and pyrimethamine [28], ampicillin, dicloxacillin, flucloxacillin and amoxicillin [29], trazodone, amineptine and amitriptyline hydrochloride [30], metoclopramide and oxybuprocaine [31], and some H1-antihistaminics [32] in pharmaceutical preparations using Mo(V)thiocyanate reagent.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of novel analytical methods for estimation of doxofylline in bulk and dosage forms

Sunil¹,

Saradhi

Sekaran³

et al. 2011

Eur. J. Chem.

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KEYWORDSThree simple, sensitive and accurate spectrophotometric methods (A, B and C) were developed to determine doxofylline in bulk and in its dosage forms. Method A is based on charge-transfer complex formation of the drug with p-chloranilic acid. Method B involves the formation of colored chloroform extractable ion-pair complex of the drug with bromophenol blue under acidic condition. Method C is based on ternary complex formation of the drug with molybdenum(V) thiocyanate binary complex. The colored products are quantitated spectrophotometrically at 540, 390 and 690 nm by methods A, B and C, respectively. The variables, which affected the reactions were carefully studied and optimized. The linear ranges for the proposed methods were 4-32 μg/mL (method A & B) and 2-16 μg/mL (method C). Analytical performance of the methods was statistically validated. The proposed methods were successfully applied to the analysis of doxofylline in its dosage forms and were found to be comparable with that of reference method.

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Section: Introductionmentioning

confidence: 99%

Development and validation of novel analytical methods for estimation of doxofylline in bulk and dosage forms

Sunil¹,

Saradhi

Sekaran³

et al. 2011

Eur. J. Chem.

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“…Analysis of organic samples by extraction of ionpairs with acidic and basic dyestuffs using molecular spectrophotometry has been known for many years [26][27][28][29][30][31][32]. AMB has also been determined in this way using acidic dyes as ion-pairing reagents [12,[33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Colorimetric and Atomic Absorption Spectrometric Determination of Mucolytic Drug Ambroxol Through Ion-Pair Formation with Iron and Thiocyanate

Levent¹,

Şentürk

2010

CCHTS

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Colorimetric and atomic absorption spectrometric methods have been developed for the determination of mucolytic drug Ambroxol. These procedures depend upon the reaction of iron(III) metal ion with the drug in the presence of thiocyanate ion to form stable ion-pair complex which is extractable in chloroform. The red-colored complex was determined either colorimetrically at 510 nm or by indirect atomic absorption spectrometry (AAS) via the determination of the iron content in the formed complex. The optimum experimental conditions for pH, concentrations of Fe 3+ and SCN, shaking time, phase ratio, and the number of extractions were determined. Under the proposed conditions, linearity was obeyed in the concentration ranges 4.1x10 -6 -5.7x10 -5 M (1.7-23.6 g mL -1 ) using both methods, with detection limits of 4.6x10 -7 M (0.19 g mL -1 ) for colorimetry and 1.1x10 -6 M (0.46 g mL -1 ) for AAS. The proposed methods were applied for the determination of Ambroxol in tablet dosage forms. The results obtained were statistically analyzed and compared with those obtained by applying the high-performance liquid chromatographic method with diode-array detection.

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“…Several methods have been reported in the literature for the determination of Ch-HCl including spectrophotometric methods [2][3][4][5][6][7][8], potentiometric method using NIO Metrhom electrode [9], thin layer chromatography [10,11], plastic membrane ion selective electrode based on Tetrakis (4-chlorophenyl)borate [12], indirectly via its complexation with metal ions using Atomic Absorption Spectrometry [13], polarography [14] and differential pulse voltammetry [15].…”

Section: Introductionmentioning

confidence: 99%

Flow injection potentiometric determination of Chlorphenoxamine Hydrochloride

Abdel‐Ghani

Hussein

2010

J Appl Electrochem

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New Chlorphenoxamine (Ch) ion selective plastic membrane electrodes for both conventional and coated wire types based on the ion associate of Ch-HCl with sodium tetraphenylborate (NaTPB) and phosphotungestic acid (PTA) were prepared. The conventional type electrode was fully characterized in terms of membrane composition, plasticizer, filling solution, life span, pH, ionic strength, temperature. The membranes of optimum compositions were used for the preparation of both graphite and cupper coated wire electrodes. The prepared electrodes were used for the potentiometric determination of the investigated drug in raw material and pharmaceutical preparations under batch and flow injection analysis conditions. The selectivity of the electrodes towards a large number of excipients like inorganic cations, sugars, amino acids and other antihistaminic drugs was tested. Determination of Ch-HCl, the solubility product of the ion associate and the formation constant of the precipitation reaction leading to the ion associate formation of Ch-HCl with NaTPB and PTA were carried out using conductimetric measurements.

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Spectrophotometric determination of some histamine H1-antagonists drugs in their pharmaceutical preparations

Cited by 33 publications

References 35 publications

Development and validation of novel analytical methods for estimation of doxofylline in bulk and dosage forms

Development and validation of novel analytical methods for estimation of doxofylline in bulk and dosage forms

Colorimetric and Atomic Absorption Spectrometric Determination of Mucolytic Drug Ambroxol Through Ion-Pair Formation with Iron and Thiocyanate

Flow injection potentiometric determination of Chlorphenoxamine Hydrochloride

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