Spectrophotometric determination of some fluoroquinolone antibacterials by binary complex formation with xanthene dyes

El-Brashy, A.; Metwally, Mohammed El‐Sayed; El-Sepai, Fawzi

doi:10.1016/j.farmac.2004.07.001

Cited by 136 publications

(61 citation statements)

References 32 publications

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“…Generally, the limited aqueous solubility of the produced drug-dye complexes was solved by either extracting the complex with an organic solvent [54] or adding a non-ionic surfactant as methyl cellulose [55]. Alternatively, El-Brashy et al [56] reported a simpler solution for such a problem, which is based on keeping the sample concentration at maximum dilution before adding the dye solution and mixing the solution well before the addition of buffer solution. Accordingly, by adopting the above procedure, the stability and solubility of the produced MCP-ESN complex were achieved without the need of lengthy extraction steps or the use of non-ionic surfactants.…”

Section: Citationmentioning

confidence: 99%

Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

AH¹,

TAS²,

AS³

2017

Pharm Anal Acta

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Three simple, selective, accurate and precise spectrophotometric methods were developed for the determination of Metoclopramide Hydrochloride (MCP) in dosage forms. The first method (Method A) is based on coupling reaction of diazotized MCP with 2,5-diphenyl-2,4-dihydro-pyrazol-3-one (DPP) in alkaline medium to form azo dye. The second method (Method B) is based on Schiff's base formation reaction between MCP and 4-hydroxybenzaldehyde (HBD). The last method (Method C) is based on the formation of colored ion-pair complex from the reaction of MCP with Eosin Y (ESN). Beer's law was obeyed in the concentration range of 1.35-40.37, 1.01-5.05 and 1.01-10.09 µg/mL MCP at 426, 386 and 543 nm with molar absorptivity of 1.51×10 4 L mol -1 cm -1 , 2.10×10 4 L mol -1 cm -1 and 3.34×10 4 L mol -1 cm -1 for Method A, Method B and Method C, respectively. The proposed methods were successfully applied to the determination of MCP in pharmaceutical preparations without any interference from common excipients.

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Section: Citationmentioning

confidence: 99%

Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

AH¹,

TAS²,

AS³

2017

Pharm Anal Acta

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“…The synthesis of xanthenes and dibenzoxanthenes' derivatives have received significant attention in recent years because of their wide range of biological and pharmaceutical properties such as agricultural bactericide, 1 anti-viral, 2 antibacterial, 3 and anti-inflammatory 4 activities. Also, a number of these compounds have been considered as dyes and fluorescent visualization materials for biomolecules and laser technologies.…”

Section: Introductionmentioning

confidence: 99%

A DABCO Derived Ionic Liquid Based on Tetrafluoroborate Anion: Preparation, Characterization and Evaluation of its Catalytic Activity in the Synthesis of 14-Aryl-14H-dibenzo[a, j]xanthenes

Zare-Bidaki

Davoodnia²

2012

Bulletin of the Korean Chemical Society

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“…[1] Also, xanthenes constitute as an important class of biologically active compounds due to their broad spectrum of pharmacological activities such as antibacterial, [2] antiviral, [3] antiinflammatory activities. [4] Natural and synthetic xanthene derivatives are also well-known for their ability to act as antioxidants and/or enzyme inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives

Zukić¹,

Veljović²,

Špirtović-Halilović³

et al. 2018

Croat. Chem. Acta

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Ten biologically active 2,2,5,5-tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, 1 H and 13 C NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while antifungal activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.

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Spectrophotometric determination of some fluoroquinolone antibacterials by binary complex formation with xanthene dyes

Cited by 136 publications

References 32 publications

Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

A DABCO Derived Ionic Liquid Based on Tetrafluoroborate Anion: Preparation, Characterization and Evaluation of its Catalytic Activity in the Synthesis of 14-Aryl-14H-dibenzo[a, j]xanthenes

Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives

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