Spectrophotometric determination of some dibenzazepine drugs by electrophilic coupling

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

“…A second advantage of our methods is the instant formation of highly absorbing colored products in ambient conditions. Many of the other published procedures require heating for several minutes at high temperatures with or without subsequent cooling to generate a stable color [60][61][62][63][64][65] or cooling to low temperatures due to limited stability of some of the reagents used [63,66].…”

New and Sensitive Method for the Spectrophotometric Determination of Certain Tricyclic Antidepressants

“…Visible spectrophotometric methods used for the determination of IPH, DPH, CPH and TPM are of ®ve types: type I is based on coupling of the intended compound with a diazotized reagent and spectrophotometric measurement of the resulting azo dye [15]; type II involves the oxidative coupling of the drug with an electrophilic reagent, in the presence of oxidant, and measurement of the resulting chromophore [15], type III is based on ion-pair formation, and extraction with dyes, in order to develop colour for spectrophotometric determination [14]; the reaction of type IV uses electron acceptor like chloranil and electron donor such as IPH. The resultant product is a coloured charge-transfer complex which is measured spectrophotometrically [16]; and type V is based on the use of a suitable oxidant in an acidic medium to produce colour for the spectrophotometric measurement [ 17± 19].…”