Spectrophotometric Determination of Phenols in Aqueous Solution via Oxidative-Coupling Reaction with 4-Amino-N,N-Diethylaniline and Potassium Dichromate

Al-Abachi, Mouayed Q.; Al-Sharook, M.M.; Al-Najafi, S.

doi:10.33899/edusj.2005.83087

Cited by 3 publications

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“…The organic and pharmaceutical compounds have been estimated using traditional methods such as gravimetric (48,49) and volume (50,51,52,53) of different types, but these methods did not respond to the possibility of determination trace quantities of these compounds, as well as chemical interference and length of analysis time, and this is what led there is an increasing need to estimate trace or archaeological quantities of such compounds in various samples of industrial, food and biological sources such as blood, urine, etc., using automatic and high-sensitivity methods. The most prominent of these is the direct and indirect determination using flame and thermo atomic absorption spectroscopy because of the advanced advantages of this technique, including:…”

Section: Atomic Absorption Spectrometrymentioning

confidence: 99%

Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

kadhim¹,

Alsailawi²,

Mudhafar³

et al. 2023

World J. Adv. Res. Rev.

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The present study includes analytical methods for determination of the drugs Chlorpromazine hydrochloride (CPZ) and trifluoperazine hydrochloride (TFPH) in some pharmaceuticals using molecular absorption, indirect AAS, in addition to investigating complexes obtained throughout. Chlorpromazine hydrochloride and trifluoperazine hydrochloride are widely used for the treatment of schizophrenia. Synthetic formulas for the prepared drug complexes were proposed through the results of the molar ratios of the combination between the drug and each of copper, lead, chrome and iron.

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Section: Atomic Absorption Spectrometrymentioning

confidence: 99%

Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

kadhim¹,

Alsailawi²,

Mudhafar³

et al. 2023

World J. Adv. Res. Rev.

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“…This reaction does not require the use of an organic solvent and is of green reaction chemistry [12]. Various analytical methods have been used in the literature, such as microbiological assay [immunoassay, UV spectrophotometric (UV-visible) liquid chromatography-mass spectrometry (LC-MS) [12][13][14], capillary electrophoresis (CE), ultrahigh performance liquid chromatography (UHPLC) [14], and ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) for the determination of compounds in drug preparations [2,15]. The microbiological method was used as a standard method for the determination of folic acid.…”

Section: Introductionmentioning

confidence: 99%

Determination of Folic Acid in both Pure and Pharmaceutical Preparations via Oxidative Coupling Reaction

Sager,

Katoof,

Radh

2023

Iraqi Journal of Science

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In this study, the development of an indirect spectrophotometric method for the determination of folic acid in pure and pharmaceutical preparations is described. The method is based on the oxidation of pyrocatechol with iron (III) in an acidic medium, followed by the reaction with folic acid (FA) to produce a stable, water-soluble orange compound with maximum absorption at 350 nm versus the blank reagent. The complex of charge transfer was studied under optimal conditions; the titration graph was linear over the range of 0.5-25 μg/mL with a relative error of 1.2-2.8 and a relative standard deviation of 2.43-1.45 depending on the concentration level.

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“…Other methods used oxidative coupling reaction with different reagents such as: promethazine in the presence of hypochlorite as oxidizing agent (Al-Abachi et al, 1995), 4amino-N,N-diethylaniline in the presence of dichromate in acidic medium (Al-Abachi, 1997) by using the same method (Al-Talib,1997) replaced the reagent with 4-amino-N,Ndimethylaniline, and N,N-diethyl-p-phenylendiamine sulphate in the presence of KIO 4 was used (Nagaraja et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric and High Performance Liquid Chromatographic Methods for the Determination of Dapsone in a Pharmaceutical Preparation

Sarsam¹

2013

RJS

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The detailed investigation of a sensitive and selective spectrophotometric method for the determination of dapsone; based on the oxidative coupling reaction of dapsone drug with pyrocatechol in the presence of potassium periodate in acidic medium to form an intense, stable, purple-red coloured water-soluble dye, which shows a maximum absorption at 509 nm. Beer's law obeyed over the range of 10-500 µg /25 ml, i.e,0.4-20 ppm with a molar absorptivity of 1.05×10 4 l.mol-1 .cm-1 and Sandell's sensitivity index of 0.0235 µg.cm-2 ,a relative standard deviation of ±2.60 to ±1.05%; and limit of detection, (LOD) of 0.1735 µg.ml-1 .; and (LOQ) of 0.5785µg.ml-1. And the method does not require temperature control or solvent extraction. HPLC technique has been also developed for the measurement of dapsone. The analysis was achieved on a C 18 column using water and acetonitrile in the ratio of 50:50 (V:V) as a mobile phase at a flow rate equals to 0.5 ml / min. and the detection was done spectrophotometrically at 297 nm. A linear relationship is obeyed over the range 0.5-20 ppm with a relative standard deviation (RSD) ±1.53 to ±0.83% and relative error-0.3 to +1.1 %. Both methods were applied successfully to the assay of dapsone in pharmaceutical preparation (Tablet).

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Spectrophotometric Determination of Phenols in Aqueous Solution via Oxidative-Coupling Reaction with 4-Amino-N,N-Diethylaniline and Potassium Dichromate

Cited by 3 publications

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Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

Determination of Folic Acid in both Pure and Pharmaceutical Preparations via Oxidative Coupling Reaction

Spectrophotometric and High Performance Liquid Chromatographic Methods for the Determination of Dapsone in a Pharmaceutical Preparation

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