Spectrophotometric Determination of Naproxen in Pure and Pharmaceutical Preparations

Khan, Islam Ullah; Aman, Tehseen; Ashraf, Ambreen; Kazi, Asrar Ahmad

doi:10.1080/00032719908542950

Cited by 25 publications

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References 13 publications

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“…Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, [3][4][5] spectrofluorimetry, [6][7][8] room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, [12][13][14] capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniques are timeconsuming, involving the use of organic solvents or require expensive and sophisticated instruments and for this reason they are not suitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Santini¹,

Oliveira²,

Pezza³

et al. 2006

J. Braz. Chem. Soc.

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As características, o desempenho e a aplicação de um eletrodo do tipo Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, onde NAP=íon naproxenato, são descritas. O eletrodo responde a NAP com sensibilidade de (58,1± 0,9) mV década -1 no intervalo de 5,0 × 10 -5 -1,0 × 10 -2 mol L -1 , a pH 6,0-9,0 e com um limite de detecção de 3,9 × 10 -5 mol L -1 . O eletrodo é de baixo custo e facilmente construído, apresenta um rápido tempo de resposta (10-35 s) e pode ser usado por um período de seis meses sem qualquer divergência considerável nos potenciais. O sensor supracitado mostrou boa seletividade para naproxeno na presença de várias substâncias, tais como carboxilatos e ânions inorgânicos, sendo aplicado na análise direta de naproxeno em medicamentos (comprimidos) via método da adição de padrão. Os resultados analíticos obtidos com o eletrodo proposto estão em boa concordância com aqueles obtidos pelo procedimento preconizado na Farmacopéia Americana.The characteristics, performance, and application of an electrode, namely, Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, where NAP stands for naproxenate ion, are described. This electrode responds to NAP with sensivity of (58.1± 0.9) mV decade -1 over the range 5.0 × 10 -5 -1.0 × 10 -2 mol L -1 at pH 6.0-9.0 and a detection limit of 3.9 × 10 -5 mol L -1 . The electrode is easily constructed at a relatively low cost with fast response time (within 10-35 s) and can be used for a period of 6 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of naproxen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.Keywords: naproxenate-sensitive electrode, potentiometry, pharmaceutical formulations Introduction Naproxen [(+)-2-(6-metoxy-2naphthyl)propionic acid], is a non-steroidal anti-inflammatory drug that also presents analgesic and antipyretic properties often preferred to acetylsalicylic acid because of its better absortion following oral administration and fewer adverse effects.Naproxen is extensively used in the treatment of many diseases like rheumatoid arthrits, degenerative joint disease, ankylosing spondylits, acute gout and primary dismenorrea. 1 Like other non-steroidal anti-inflammatory drugs, it inhibits the biosyntesis of prostaglandins. 1 The United States Pharmacopeia 2 2003 reports an highperformance liquid chromatography (HPLC) method for the determination of naproxen tablets. Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, 3-5 spectrofluorimetry, 6-8 room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, 12-14 capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniq...

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Section: Introductionmentioning

confidence: 99%

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Santini¹,

Oliveira²,

Pezza³

et al. 2006

J. Braz. Chem. Soc.

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“…Several analytical methods have been reported for determining NAP including spectrophotometry [2,3], fluorometry [4,5], synchronous spectrometry [6], phosphorimetry [7], voltammetry [8,9], liquid chromatography [10,11], capillary electrophoresis [12], high performance liquid chromatography (HPLC) [13][14][15], and chemiluminescence (CL) [16][17][18][19][20]. Among the above methods, CL coupled with flow injection offers the advantages of equipment simplicity, high detection sensitivity, low background noise and good reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticle-Enhanced Chemiluminescence Method for Determining Naproxen Based on Europium(III)-Sensitized Ce(IV)-Na2S2O4 Reaction

et al. 2012

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A simple and sensitive chemiluminescence (CL) method coupled with flow-injection technique is proposed to determine naproxen (NAP). The method is based upon the enhancement of the weak CL signal arising from the reaction of Ce(IV) and Na(2)S(2)O(4) with Eu(3+) to form the Eu(3+)-Ce(IV)-Na(2)S(2)O(4) system. The CL intensity was significantly increased by the introduction of NAP into this system in the presence of silver nanoparticles (Ag NPs). Examination of the recorded UV-vis spectra and fluorescence spectra indicated that the energy of the intermediate SO(2)*, which originated from the redox reaction of Ce(IV) and Na(2)S(2)O(4), was transferred to Eu(3+) via NAP and that the process was accelerated by Ag NPs due to their catalytic activity. Under the optimum conditions, the CL intensity was increased with increasing NAP concentration and the correlation was linear (r = 0.9992) over the NAP concentration range of 1-420 ng mL(-1). The limit of detection (LOD) was 0.11 ng mL(-1) with a relative standard deviation (RSD) of 1.15% for 5 replicate determinations of 200 ng mL(-1) NAP. The method was successfully applied to determine NAP in pharmaceutical and biological samples.

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“…Various analytical methods have been reported for the determination of naproxen in pharmaceutical preparations and in biological fluids, including spectrophotometry, [3] fluorometry, [4,5] phosphorimetry, [6] voltammetry, [7,8] liquid chromatography, [9] capillary electrophoresis [10] and CL methods, [11][12][13][14] which were based on the CL reactions of KMnO 4 -Na 2 SO 3 , [11] Na 2 SO 3 -SDBS, [12] Ru(bpy) 3 2+ -PbO 2 [13] or direct oxidation with Ce(IV). [14] The trivalent lanthanide ions, especially europium(III) ion and terbium(III) ion, have recently been shown to be the useful CL sensitizers for chemical and biological applications.…”

Section: Introductionmentioning

confidence: 99%

Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO₄–H₂O₂ reaction

Du¹,

Li²,

Lu³

2009

Luminescence

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A simple and sensitive chemiluminescence (CL) method combined with flow injection technique was developed for the determination of naproxen. It was based upon the weak CL signal arising from the reaction of KIO(4) with H(2)O(2) being significantly increased by naproxen in the presence of europium(III) ion. The experimental conditions that affected the CL signal were carefully optimized and the CL reaction mechanism was briefly discussed. Under the optimum conditions, the increment of CL intensity was proportional to the concentration of naproxen ranging from 5.0 x 10(-8) to 5.0 x 10(-6) g/mL. The detection limit was 1 x 10(-8) g/mL naproxen and the relative standard deviation for 5.0 x 10(-7) g/mL naproxen solution was 2.1% (n = 11). The proposed method was applied to the determination of naproxen in tablets and in spiked human urine samples with satisfactory results.

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Spectrophotometric Determination of Naproxen in Pure and Pharmaceutical Preparations

Cited by 25 publications

References 13 publications

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Silver Nanoparticle-Enhanced Chemiluminescence Method for Determining Naproxen Based on Europium(III)-Sensitized Ce(IV)-Na2S2O4 Reaction

Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO₄–H₂O₂ reaction

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Spectrophotometric Determination of Naproxen in Pure and Pharmaceutical Preparations

Cited by 25 publications

References 13 publications

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Silver Nanoparticle-Enhanced Chemiluminescence Method for Determining Naproxen Based on Europium(III)-Sensitized Ce(IV)-Na2S2O4 Reaction

Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO4–H2O2 reaction

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Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO₄–H₂O₂ reaction