Spectrophotometric and spectrofluorometric methods for the determination of non-steroidal anti-inflammatory drugs: A review

Gouda, Ayman A.; El-Sayed, Mohamed I. Kotb; Amin, Alaa S.; Sheikh, Ragaa El

doi:10.1016/j.arabjc.2010.12.006

Cited by 101 publications

(59 citation statements)

References 98 publications

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“…As revealed above eosin Y is one of the important fluorescent ion pairing agent and spectrofluorimetric technique play an important role in the analysis of many pharmaceutical compounds and active current research area as a number of research articles and reviews published every year on this topic [102][103][104][105][106][107][108]. Spectrofluorimetry provides an extremely sensitive, selective and simple method for a variety of active pharmaceutical ingredients at a very low detection limits up to pictogram range [109].…”

Section: Resultsmentioning

confidence: 99%

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Rahman

2017

Int J Pharm Pharm Sci

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Globally, dyes are widely used in the pharmaceutical, food, textile, cosmetics, plastics, leather, paint, ink and paper industries. Eosin is an acidic orange-pink dye and has very strong staining properties. Haematoxylin and eosin Y (H and E) combination is the most common staining and primary diagnostic technique in histo-pathological laboratories. This review mainly discussed the utility of eosin dye in quality control laboratories as an ion pairing agent for drug analysis. Eosin Y is one the most common ion pairing agent and its mono and di anionic forms are capable of interacting with many drug molecules to form colored/fluorescent binary or ternary complexes that can be analyzed with or without extraction by spectrofluorimetry and/or spectrophotometry. Quenching fluorescence and advantages of spectrofluorimetry over spectrophotometry were also discussed. Fluorescence detection greatly enhances the sensitivity and providing a sensitive and relatively inexpensive instrumental method of analysis using eosin Y for various important drugs in pure, commercial dosage forms and biological fluids.

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Section: Resultsmentioning

confidence: 99%

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Rahman

2017

Int J Pharm Pharm Sci

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“…[3] The NSAIDs exist in highly ionized forms in plasma and have the ability to bind with plasma proteins (>97 %), due to favora-almost invariably different from the original NSAID target. [4] The NSAIDs are classified according to their chemical structures into the following groups: (i) salicylic acid derivatives, (ii) aniline and p-aminophenol derivatives, (iii) pyrazolone derivatives, (iv) oxicams, (v) arylalkanoic acid derivatives, (vi) 2-arylpropionic acid derivatives, (vii) N-arylanthranilic acids, (viii) enolic acid derivatives, (ix) coxibs (selective COX-2 inhibitors), (x) naphthylbutanone derivatives, (xi) sulfonamides, and (xii) benzoxazocine derivatives. The study shows that the molecular weights of metal complexes containing the same NSAID are linearly related to their IC 50 values against MCF-7 cells.…”

Section: Introductionmentioning

confidence: 99%

Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level

2016

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The nonsteroidal anti-inflammatory drugs (NSAIDs) make up a great group of drugs that provide benefits in the prevention of cancers. Coordinated metal ions with NSAIDs provide advantages over the drugs themselves. The metal complexes of NSAIDs display a range of biological activities quite often inaccessible to the original NSAID ligands. NSAIDs-metal complexes have molecular properties different from those of the parent drugs. Thus, if a given NSAIDs-metal complex remains intact in the biological medium its biological target is [a] She is now a Postdoctoral Fellow of the National Scholarships Foundation of Greece-Siemens program with a fellowship of excellence. Her research interests are mainly focused on bioinorganic chemistry and particularly on the evaluation of the anticancer properties of metal complexes by studying their interaction with intracellular molecules. Sotiris K. Hadjikakou was born in Famagusta, Cyprus. He graduated from the Chemistry 3049 dentate, bidentate, or bridge ligands in polynuclear complexes.Compounds of NSAIDs with biometals exhibit better pharmacological activity than free NSAIDs. [11] The structural characteristics, medicinal/veterinary properties, superoxide dismutase (SOD) activity [SOD is an enzyme that catalyzes the dismutation of the superoxide (O 2 -) radical into both ordinary molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ), thus being involved in the inflammation mechanism], anti-inflammatory, and ulcerogenic effects of Cu-NSAIDs have also been reviewed. [5] The review concluded that the mode of action of the Cu-NSAIDs is similar to that of the traditional NSAIDs and the complexes reduced gastrointestinal toxicity. Moreover, the stabilities of Cu-NSAIDs complexes are a critical determinant of their activity and toxicity. [5] This review summarizes the complexes of NSAIDs: (i) acetylsalicylic acid, diflunisal, salicylic acid (salicylic acid derivatives, Scheme 1), (ii) diclofenac, indometacin, sulindac, tolmetin (arylalkanoic acid derivatives, Scheme 2), (iii) ibuprofen, ketoprofen, Scheme 1. Salicylic acid derivatives.Scheme 2. Arylalkanoic acid derivatives. MicroreviewScheme 3. Arylpropionic acid derivatives (profens).Scheme 4. N-Arylanthranilic acid (fenamic acids). 3050Scheme 5. Other acid derivatives.Scheme 6. Oxicams. MicroreviewScheme 7. Aniline and p-aminophenol derivatives.Scheme 8. Sulfonamides. Discussion Metal Complexes of NSAIDs Exhibiting Anti-Inflammatory or Analgesic ActivityMn II -, Fe II -, Co II -, Ni II -, and Zn II -Schiff base complexes that contain anthranilic acid and aldoses in the Schiff base component are four-coordinate in the anhydrous state with the general formula ML 2 [M = Mn II (1), Fe II (2), Co II (3), Ni II (4), and Zn II (5), Scheme 9]. They were tested for their in vivo biological activities. The stability of the complexes in DMSO solution was confirmed by 1 H NMR spectroscopy. The relative toxicities of the metal complexes were determined with albino Wistar male rats; the LD 50 values followed the trend Ni < Mn < Co < Fe < Zn, w...

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“…1 Later, other oxicam derivatives including; tenoxicam (TXM, 4-hydroxy-2-methyl-N-(pyridine-2-yl)-2H-thieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide) and meloxicam (MXM, 4-hydroxy-2-methyl-N-(5methyl-2-thiazolyl)-2H-1,2-benzo-thiazine-3-carboxamide-1,1di-oxide) were widely prescribed as medication. 3,4 Bibliography data 3 indicate that only liquid chromatographic methods with UV 5 or MS detection 6 have been used for LXM determination. 2 Different official and non-official methods for analysis of oxicams (OXMs) were found in the literature.…”

Section: Introductionmentioning

confidence: 99%

Novel screen printed potentiometric sensors for the determination of oxicams

et al. 2015

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The construction and performance characteristics of new sensitive and selective sensors based on functionalized multi-walled carbon nanotubes/b-cyclodextrin nanocomposite (FMWCNTs/b-CD) was demonstrated for potentiometric determination of different anti-inflammatory agents including lornoxicam, meloxicam, piroxicam and tenoxicam. Screen printed sensors (SPEs) modified with FMWCNTs/b-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-PNPE) showed proper electroanalytical performances with a Nernstian compliance range between 61.2 and 52.6 mV decade À1 activity and a detection limit of 6.0 Â 10 À7 mol L À1 for different oxicam derivatives. Modification with carbon nanotube composite as sensing material remarkably improved the potential stability and lifetime of the fabricated sensors. The proposed sensors offer a simple analytical tool for determination of different oxicam derivatives in their pharmaceutical formulations under batch and flow injection analysis (FIA) conditions.

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Spectrophotometric and spectrofluorometric methods for the determination of non-steroidal anti-inflammatory drugs: A review

Cited by 101 publications

References 98 publications

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level

Novel screen printed potentiometric sensors for the determination of oxicams

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