Novel screen printed potentiometric sensors for the determination of oxicams

Abstract

The construction and performance characteristics of new sensitive and selective sensors based on functionalized multi-walled carbon nanotubes/b-cyclodextrin nanocomposite (FMWCNTs/b-CD) was demonstrated for potentiometric determination of different anti-inflammatory agents including lornoxicam, meloxicam, piroxicam and tenoxicam. Screen printed sensors (SPEs) modified with FMWCNTs/b-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-PNPE) showed proper electroanalytical performances with a Nernstian compliance range between 61.2 and 52.6 mV decade À1 activity and a detection limit of 6.0 Â 10 À7 mol L À1 for different oxicam derivatives. Modification with carbon nanotube composite as sensing material remarkably improved the potential stability and lifetime of the fabricated sensors. The proposed sensors offer a simple analytical tool for determination of different oxicam derivatives in their pharmaceutical formulations under batch and flow injection analysis (FIA) conditions.

Disposable Nafion-Coated Single-Walled Carbon Nanotube Test Strip for Electrochemical Quantitative Determination of Acetaminophen in a Finger-Prick Whole Blood Sample

“…This enables the production of inexpensive disposable SWCNT electrodes on a wide range of substrates including polymers. Carbon nanotube-modified screen-printed electrode strips have also been previously reported. − The fabrication of such electrodes, however, requires preparation of special carbon nanotube composite ink formulations or modification of the electrodes after screen printing. In contrast, the dry transfer process directly produces a high-surface-area electrode with high conductivity.…”

An Overview of Recent Electroanalytical Applications Utilizing Screen‐Printed Electrodes Within Flow Systems

“…[36] In all the aforementioned papers, very low LODs (� 0.004 μmol L À 1 ) were obtained for the analysis of pesticides in natural water samples. In addition, in 2015, FIA-SPE methods were also explored for the determination of analytes such as methimazole, [17] nimodipine, [37] biotin, [15] pioglitazone, [38] oxicams derivatives, [39] H 2 O 2 , [14,40] nitromethane, [41] glucose, [42] 3hydroxyanthranilic acid, [43] bromate, [44] phosphate through monitoring of an electroactive complex obtained by the reaction between phosphate and molybdate, [45] and iodide. [46] During the year 2016, the possibility of determination of free chlorine, [47] hydroquinone, [48] labile copper, [49] Cr(VI), [50] and zinc phenolsulfonate [24] were reported.…”

“…[81] Similar to FIA, BIA systems also allow for Gaussian shapes to be obtained via the injection of small solution volumes (10 to 150 μL). However, this is possible without the use of tubes and connections (without leaks or air bubbles), pumping systems, [13] Hydrogen peroxide Hair colorant and milk CNTSPE modified with metal NPs 20 450 [14] Biotin PF SPCE modified with horseradish peroxidase 0.008 13 [15] Paracetamol Naproxen PF SPCE and MWCNTSPE 0.4 0.3 90 [16] Methimazole Human serum and PF SPCE modified with (IrOxNPs) and tyrosinase 0.004 36 [17] Paraoxon Drinking, river and lake water SPGE modified with butyrylcholinesterase and PB NPs 0.004 NR [18] Gallic acid White and red wine SPEÀ Au-SAM/AuNPs-Linker/ Fullerenols/TvL 6.5 14 [34] Chlorpyriphos-oxon Malaoxon Milk SPCE modified with acetylcholinesterase 0.000005 19 [35] Organophosphate insecticide Lake water Carbon paste SPE modified with enzyme magnetic beads 0.003 18 [36] Nimodipine PF Carbon nanofiber SPE 0.08 NR [37] Pioglitazone PF SPE modified with MWCNT -polyvinyl chloride 0.8 90 [38] Oxicam derivatives PF, plasma and urine SPE modified with MWCNT -b-cyclodextrin 0.6 240 [39] [42] 3-hydroxyanthranilic acid Urine AuSPE modified with MIPs 0.02 225 [43]…”

“…In all the aforementioned papers, very low LODs (≤0.004 μmol L −1 ) were obtained for the analysis of pesticides in natural water samples. In addition, in 2015, FIA‐SPE methods were also explored for the determination of analytes such as methimazole, nimodipine, biotin, pioglitazone, oxicams derivatives, H 2 O 2 , nitromethane, glucose, 3‐hydroxyanthranilic acid, bromate, phosphate through monitoring of an electroactive complex obtained by the reaction between phosphate and molybdate, and iodide …”