Spectrophotometric and Spectrofluorimetric Determination of 1,4-Dihydropyridine Drugs Using Potassium Permanganate and Cerium (Iv) Ammonium Sulphate

Askal, Hassan F.; Abdelmegeed, Osama H; El-Hamd, Mohamed Abo

doi:10.21608/bfsa.2010.64763

Cited by 13 publications

(10 citation statements)

References 17 publications

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“…The accuracy of the method was demonstrated by analyzing different concentrations covering the points in the calibration range (10,15,20,25, 30 μg/mL) for nifedipine and (40, 45, 50, 55, 60 µg/mL) for atenolol. All concentrations were injected in triplicate.…”

Section: Accuracymentioning

confidence: 99%

“…Several analytical methods have been developed for nifedipine and atenolol quantification in pharmaceuticals. The most recent methods include UV-VIS spectrophotometry [9][10][11][12][13][14] and HPLC [15][16][17][18][19]. The scientific novelty of the present work is that the methods used are simple, rapid, selective, and less expensive and less time consuming compared with the other published methods.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Determination of Atenolol and Nifedipine by Using Spectrophotometric Method with Multivariate Calibration and HPLC Method Implementing ?Design of Experiment?

Abdallah¹,

Ibrahim²,

Ibrahim³

et al. 2015

Pharm Anal Acta

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Objectives: The aim of the present work is to develop rapid and simple methods for the simultaneous determination of atenolol and nifedipine. Multivariate calibration using preprocessing methods to enhance results in case of presence of any interference in samples and RP-HPLC method for achieving a good separation with accepted system suitability parameters with the use of design of experiment for robustness testing according to Plackett-Burman design. Methods: The spectrophotometric method is based on the measurement of the mixture in the range of 200-400 nm then applies the multivariate calibration methods for resolution of the binary mixture mainly using partial least squares (PLS) and principal component regression (PCR). The proposed RP-HPLC method utilizes an YMC-pack pro C 18 column (250 mm x 4.6 mm, 5 μm). Optimum chromatographic conditions were attained by application of Design of experiment (DOE). Both spectrophotometric and chromatographic methods were applied on the determination of both drugs in marketed capsules. Also, dissolution testing of these capsules was investigated. Results: The recovery percentage for nifedipine and atenolol in capsules dosage form were found to be in PLS method (100.50 ± 0.850, 100.78 ± 1.07), PCR method (100.60 ± 0.960, 100.72 ± 1.09) and RP-HPLC method (99.77 ± 0.560, 100.90 ± 1.23); respectively. Conclusion: The methods were validated according to ICH guidelines. All the results obtained were found to be within the acceptable limits. The methods were successful to estimate nifedipine and atenolol in bulk powder and pharmaceutical preparation.

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Section: Accuracymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Atenolol and Nifedipine by Using Spectrophotometric Method with Multivariate Calibration and HPLC Method Implementing ?Design of Experiment?

Abdallah¹,

Ibrahim²,

Ibrahim³

et al. 2015

Pharm Anal Acta

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“…However, some of these methods are expensive, somewhat time consuming and require sophisticated instruments that may be unavailable in many quality control laboratories. In comparison with HPLC technique the developed method is simple, cost effective and it is sensitive than other reported methods as HPLC [9] , HPTLC [15] and more selective and sensitive than reported spectrophotometric method which its linear range is 5.0–30.0 μg/mL [22] . Therefore, the development of more simple, rapid, selective and sensitive method for the determination of AML is necessary.…”

Section: Introductionmentioning

confidence: 99%

“…Spectrophotometry because of its inherent simplicity is considered one of the most convenient alternative techniques. Few spectrophotometric methods have been reported for the determination of AML [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] . However, some of these methods are expensive, somewhat time consuming and require sophisticated instruments that may be unavailable in many quality control laboratories.…”

Section: Introductionmentioning

confidence: 99%

Kinetic spectrophotometric method for determination of amlodipine besylate in its pharmaceutical tablets

Mahmoud

Abdel-Wadood

Mohamed

2012

Journal of Pharmaceutical Analysis

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A simple and sensitive kinetic spectrophotometric method has been developed and validated for determination of amlodipine besylate (AML). The method was based on the condensation reaction of AML with 7-chloro-4-nitro-2,1,3-benzoxadiazole in an alkaline buffer (pH 8.6) producing a highly colored product. The color development was monitored spectrophometrically at the maximum absorption λ max 470 nm. The factors affecting the reaction were studied and the conditions were optimized. The stoichiometry of the reaction was determined, and the reaction pathway was postulated. Moreover, both the activation energy and the specific rate constant (at 70 °C) of the reaction were found to be 6.74 kcal mole −1 and 3.58 s −1 , respectively. The initial rate and fixed time methods were utilized for constructing the calibration graphs for the determination of AML concentration. Under the optimum reaction conditions, the limits of detection and quantification were 0.35 and 1.05 μg/mL, respectively. The precision of the method was satisfactory; the relative standard deviations were 0.85–1.76%. The proposed method was successfully applied to the analysis of AML in its pure form and tablets with good accuracy; the recovery percentages ranged from 99.55±1.69% to 100.65±1.48%. The results were compared with that of the reported method.

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“…Many analytical methods were developed for determination of 1,4-DHP drugs, namely, nifedipine (NIF), nicardipine (NIC), nimodipine (NIM), felodipine (FEL), and amlodipine (AML) (Figure 1), in their pharmaceutical formulations and in biological fluids, such as titrimetric methods [3,4], spectrometric methods (spectrophotometry [5][6][7][8][9][10][11][12][13] or spectrofluorimetry [12,[14][15][16][17][18][19][20]), electrochemical methods [21][22][23], liquid chromatographic methods [24][25][26][27][28], and gas chromatographic methods [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs UsingN-Bromosuccinimide and Indigo Carmine Dye

Hamd

Derayea

Abdelmageed

et al. 2013

International Journal of Spectroscopy

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Indirect spectrophotometric method is described for quantification of five of 1,4-dihydropyridine (1,4-DHP) drugs using N-bromosuccinimide (NBS) with the aid of indigo carmine (INC) dye. The method is based on addition of known excess of NBS to an acidified solution of 1,4-DHP drugs and determining the residual of NBS through its ability to bleach the colour of the used dye; the amount of NBS that reacted corresponded to the amount of drugs. Beer’s law is obeyed in the concentration range 1.25–13.00 μg/mL. Good correlation coefficients (0.998-0.999) were found between the absorbance values and the corresponding concentrations. Limits of detections ranged from 0.141 to 0.500 μg/mL. The proposed method was successfully applied to the analysis of dosage forms; percent of recoveries ranged from 97.31 to 99.46% without interference from any common excipients. The statistical comparison by Student’s t-test and variance ratio F-test showed no significant difference between the proposed and official or reported methods.

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Spectrophotometric and Spectrofluorimetric Determination of 1,4-Dihydropyridine Drugs Using Potassium Permanganate and Cerium (Iv) Ammonium Sulphate

Cited by 13 publications

References 17 publications

Simultaneous Determination of Atenolol and Nifedipine by Using Spectrophotometric Method with Multivariate Calibration and HPLC Method Implementing ?Design of Experiment?

Simultaneous Determination of Atenolol and Nifedipine by Using Spectrophotometric Method with Multivariate Calibration and HPLC Method Implementing ?Design of Experiment?

Kinetic spectrophotometric method for determination of amlodipine besylate in its pharmaceutical tablets

Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs UsingN-Bromosuccinimide and Indigo Carmine Dye

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