Spectrophotometric and HPTLC-densitometric determination of lisinopril and hydrochlorothiazide in binary mixtures

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

“…High Performance Liquid Chromatography (HPLC) together with various types of detection UV (ultraviolet), FD (fluorescence detection) and MS (mass spectrometry) has become the method of choice for analytical method development. Apart from these methods other analytical methods also used which are High performance thin layer chromatography [50][51][52], Ultra performance liquid chromatography [59,60], Thin layer chromatography [62], Voltammetry [16], Capillary electrophoresis [14,15] are also widely used.…”

“…The spectrophotometric methods include third derivative (3 D ) ultraviolet spectrophotometry with zero crossing measurement at 217.4 and 233.4 nm, second derivative of the ratio spectra with measurement at 214.3 and 228.0 nm; both classical least squares and principal component regression were applied to the UV absorption and first derivative spectra of the mixture. The HPTLC method was based on separation of both drugs followed by densitometric measurements of their spots at 210 and 275 nm for lisinopril and Hydrochlorothiazide, respectively [26].…”

“…The limit of detection and the limit of quantification for the Irbesartan were found to be 30 and 100 ng/spot respectively and for hydrochlorothiazide 25 and 100 ng/spot respectively. Different spectrophotometric and HPTLCdensitometric methods are presented by Gindy et al [51] for the simultaneous determination of lisinopril and hydrochlorothiazide in pharmaceutical tablets. The spectrophotometric methods include third derivative (D) ultraviolet spectrophotometry with zero crossing measurement at 217.4 and 233.4 nm, second derivative of the ratio spectra with measurement at 214.3 and 228.0 nm; The HPTLC method was based on separation of both drugs followed by densitometric measurements of their spots at 210 and 275 nm for lisinopril and hydrochlorothiazide, respectively.…”

The Evaluation of Angiotensin-Converting Enzyme Inhibitors in Renal Elimination with Selected Molecular Descriptors

“…ACE inhibitors were determined in pharmaceutical formulations and biological material. There are few data on the elimination of ACE inhibitors by peritoneal dialysate (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Physico-chemical Profiling of ACE-inhibitor Lisinopril: Acid-base Properties

“…Several analytical methods have been applied for the determination of lisinopril in biological samples and pharmaceutical preparations such as alkalimetry [11], spectrophotometry [12], high performance liquid chromatography (HPLC) [13], high performance thin-layer chromatography (HPTLC) [14], and capillary electrophoresis (CE) [15]. Obviously, upon the application of these methods, exact knowledge of acid-base chemistry is essential (for pharmacopoeial methods) or at least favourable (for chromatographic techniques and CE).…”