Spectrophotometric and Atomic Absorption Determination of Ramipril, Enalapril Maleate and Fosinopril through Ternary Complex Formation with Molybdenum (V)-Thiocyanate (Mo(V)-SCN)

Baraka, Mohamed M.; El-Sadek, Mohamed; Moussa, Ewais M.M.; Abd-Alaty, Nashat Mohamed Alanowar

doi:10.1248/cpb.56.1521

Cited by 6 publications

(4 citation statements)

References 32 publications

(24 reference statements)

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“…The proposed method was advantageous over other reported visible spectrophotometric and colorimetric methods [25,[37][38][39][40][41], related to their high reproducibility, high sensitivity, less time consuming and using simple and inexpensive reagents. Moreover, this method allowed the determination of both drugs up to 0.4 μg mL -1 , in addition to simplicity, rapidity, precision and stability of colored species for more than 48 h. The proposed method may be applied for routine analysis and in quality control laboratories for the quantitative determination of the ENM and LIS in raw materials and in pharmaceutical formulations.…”

Section: Resultsmentioning

confidence: 99%

Spectrophotometry Microdetermination of Some Antihypertensive Drugs in Pure Form and in Pharmaceutical Formulations

Shama

Amin

Omara

2011

J. Chil. Chem. Soc.

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Simple, rapid, accurate, precise and sensitive spectrophotometric method for the microdetermination of enalapril maleate (ENM) and lisinopril dihydrate (LIS) has been developed. The method is based on oxidation of the drug by potassium permanganate in acidic medium and determine the unreacted oxidant by measuring the decrease in absorbance for three different acidic dyes; acid red 73 (AR), amaranth dye [acid red 27] (AM) and acid orange 7 (AO) at a suitable λ max (510, 521 and 484 nm for ENM and 509, 521 and 485 nm for LIS), respectively. Regression analysis of Beer's law plots showed good correlation in the concentration ranges 0.7-12, 0.5-7.6 and 0.6-9.5 µg mL -1 and 0.5-9.0, 0.4-6.1 and 0.4-7.2 µg mL -1 for ENM and LIS using AR, AM and AO, respectively. The apparent molar absorptivity, Sandell sensitivity, detection and quantitation limits are calculated. Statistical treatment of the results reflects that the proposed procedures are precise, accurate and easily applicable for the determination of ENM and LIS in pure and in pharmaceutical preparations.

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Section: Resultsmentioning

confidence: 99%

Spectrophotometry Microdetermination of Some Antihypertensive Drugs in Pure Form and in Pharmaceutical Formulations

Shama

Amin

Omara

2011

J. Chil. Chem. Soc.

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“…enalapril maleate by the formation of ternary complex with copper (II) and eosin for enalapril, Fe (III) and thiocyanate for ramipril 63 . Ramipril, enalapril maleate and fosinopril were determined by the formation of ternary complex with molybdenum (V) and thiocyanate 69 .…”

Section: Atomic Absorption Spectrometric Methods Ayad Et Al Determined Ramipril Andmentioning

confidence: 99%

Analysis of Angiotensin Converting Enzyme Inhibitors and Antagonists

Khashaba

Mohamed

Shahin

2021

Sphinx Journal of Pharmaceutical and Medical Sciences

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The Angiotensin-converting enzyme inhibitors and antagonists are widely used in the management of essential hypertension, stable chronic heart failure, myocardial infarction and diabetic nephropathy, so that specific and sensitive methods are needed for the qualitative and quantitative determinations of these drugs in pharmaceutical dosage forms and in biological material. In the last few years, there was no review published covering all different analytical methods used for the determination of these drugs. The aim of this work is to review the most important recent methods for their analysis in pure forms, in different pharmaceutical dosage forms and in biological fluids due to the great importance of this class of drugs. This review includes two parts: the first part presents the methods applied for the analysis of pharmaceuticals. The second part is devoted to the methods elaborated for the assays in biological material (blood, plasma and urine).

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“…This give rise to the importance of providing a flexible analytical method that can selectively determine magnesium in high sensitivity and regardless of its salt form or other components in the product [1]. Many research showed that atomic absorption spectrometry (AAS) technique can be applied to detect trace levels of minerals in food [4], Catfish [7], geology [8] and Drugs [1,4,9,10]. Flame-AAS is an analytical technique that is frequently used to determine Mg 2+ ions in raw material or as formulated preparations; alone or with other components [1] quantitatively and qualitatively [8].…”

Section: Magnesium (Mgmentioning

confidence: 99%

A New Flame AAS Application for Magnesium Determination in Solid Pharmaceutical Preparations as an Active Ingredient and an Excipient

Sbahi

Abdelwahed

Sakur

2020

IRJPAC

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Objective: A new application of Atomic Absorption Spectroscopy (AAS) has been carried out to determine magnesium in its solid preparations (effervescent and uncoated compressed tablets) as an active ingredient and/or excipient. Methodology: The linear range of magnesium was determined. A sample of magnesium effervescent tablets was analyzed. Magnesium stearate concentration was also indirectly determined in commercial paracetamol tablets using two digestion methods. Finally, a sample of drug-free tablets (only contain excipients) was analyzed to study the effect of talc on total magnesium content of the sample. Results: Linear range was observed in concentrations between 0.08-0.40 ug/mL of magnesium. Effervescent tablets samples were recovered in the range between 98.66-103.00% which indicates that the product meets specifications. For paracetamol tablets, the content of magnesium stearate was in average of 0.2% and there is no differences between the two digestion methods (t=0.454). Our work on the drug-free sample proved a significant increase of magnesium concentrations in the presence of talc. Conclusion: The AAS method is a simple and rapid technique that can be employed for the simultaneous estimation of magnesium in in-process and final products analyses.

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Spectrophotometric and Atomic Absorption Determination of Ramipril, Enalapril Maleate and Fosinopril through Ternary Complex Formation with Molybdenum (V)-Thiocyanate (Mo(V)-SCN)

Cited by 6 publications

References 32 publications

Spectrophotometry Microdetermination of Some Antihypertensive Drugs in Pure Form and in Pharmaceutical Formulations

Spectrophotometry Microdetermination of Some Antihypertensive Drugs in Pure Form and in Pharmaceutical Formulations

Analysis of Angiotensin Converting Enzyme Inhibitors and Antagonists

A New Flame AAS Application for Magnesium Determination in Solid Pharmaceutical Preparations as an Active Ingredient and an Excipient

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