A New Flame AAS Application for Magnesium Determination in Solid Pharmaceutical Preparations as an Active Ingredient and an Excipient

Abstract

Objective: A new application of Atomic Absorption Spectroscopy (AAS) has been carried out to determine magnesium in its solid preparations (effervescent and uncoated compressed tablets) as an active ingredient and/or excipient.
 Methodology: The linear range of magnesium was determined. A sample of magnesium effervescent tablets was analyzed. Magnesium stearate concentration was also indirectly determined in commercial paracetamol tablets using two digestion methods. Finally, a sample of drug-free tablets (only contain excipients) was analyzed to study the effect of talc on total magnesium content of the sample.
 Results: Linear range was observed in concentrations between 0.08-0.40 ug/mL of magnesium. Effervescent tablets samples were recovered in the range between 98.66-103.00% which indicates that the product meets specifications. For paracetamol tablets, the content of magnesium stearate was in average of 0.2% and there is no differences between the two digestion methods (t=0.454). Our work on the drug-free sample proved a significant increase of magnesium concentrations in the presence of talc.
 Conclusion: The AAS method is a simple and rapid technique that can be employed for the simultaneous estimation of magnesium in in-process and final products analyses.

Spectrofluorimetric determination of magnesium ions in water, ampoule, and suspension samples using a fluorescent azothiazol‐benzenesulfonamide derivative

“…The LOD value of Mg 2+ using an M-sensor was 18.0 ng ml À1 , which was less than the total concentration of Mg 2+ ions in the real pharmaceutical samples. Atomic absorption spectrometry 0.08-0.40 μg ml À1 Effervescent tablets [17] Atomic absorption spectrometry 10-200% of the formula Mg 2+ content Tablets [18] Flame atomic absorption spectrometry Up to 8.5 μg ml À1 Tablets [19] Flame atomic absorption spectrometry 0.05-0.40 mg L À1 Multivitamin granulated formulation [20] Spectrophotometry 0.5-3.5 μg ml À1 Tablets [10] Spectrophotometry 0-20 mg L À1 Tablets [23] HPLC 0.00-0.04 mg ml À1 Tablets…”

“…Several methodologies have been published for magnesium detection in different environmental samples, these includes X-ray atomic spectrometric methods, [5] electrochemical methodologies, [6] atomic absorption spectroscopic methods, [7] flame atomic absorption spectrometric methods, [8] ion-selective electrode methods, [9] derivative spectrophotometric methods, [10] high performance liquid chromatography (HPLC), [11] nuclear magnetic resonance (NMR), [12] colorimetric methods, [13] graphite furnace atomic absorption spectrometric methods [14] and fluorescence methods. [15] In addition a few methodologies have been published for the determination of magnesium in different pharmaceutical samples, for example electrochemical methodologies, [16] atomic absorption spectroscopic methods, [17,18] flame atomic absorption spectrometric methods, [19,20] ion-selective electrode methods, [21] derivative spectrophotometric methods, [10] HPLC, [22] and colorimetric methods. [23] These analytical methodologies still have some drawbacks, such as full sample consumption, requirement for complex technologies steps, the necessity for use of time-consuming and costly machinery and the need for skilled operators.…”

Enhancing Curcumin and Mineral Content in Red Turmeric via Magnetic Field Exposure

“…Magnesium content was determined using Atomic Absorption Spectrophotometry (AAS) [22,23]. The stock solution is made from 1000 g/mL magnesium chloride, taken in 10 mL, and put into a 100 mL volumetric flask.…”