Spectrofluorimetric method for determination of duloxetine hydrochloride in bulk and pharmaceutical dosage forms

Prabu, S.; Shahnawaz, Sheikh; Cd, Kumar; Shirwaikar, Annie

doi:10.4103/0250-474x.44603

Cited by 17 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A survey of literature showed few analytical methods has been reported for determination of duloxetine hydrochloride in human serum and biological fluids using tandem MS and LC-MS methods 3 and HPLC 4-5 method for the estimation of duloxetine hydrochloride in pharmaceutical preparations. Determination of duloxetine hydrochloride by spectroflourimetric method [6][7] has also been reported. To the best of our knowledge, there is no report on UV-Visible spectrophotometric method for its estimation.…”

Section: Introductionmentioning

confidence: 99%

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

Yunoos¹,

Sankar

Kumar³

et al. 2009

Journal of Chemistry

View full text Add to dashboard Cite

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104L/mol.cm in 0.1 N HCL. Beer's law was found to be obeyed in the concentration range of 5-30 μg/mL. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its capsule dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

Yunoos¹,

Sankar

Kumar³

et al. 2009

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“… Pure samples: Galantamine hydrobromide was kindly supplied by Cadila Pharmaceutical Ltd. (Ahmedabad, India) Market samples: Galamer 4 mg tablets (Sun Pharmaceutical ltd.) Chemical and Reagents: Distilled water prepared by distillation unit in the laboratory was used throughout the study. [ 8 9 10 11 12 13 ] …”

Section: Methodsmentioning

confidence: 99%

Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry

Patel

et al. 2013

J Pharm Bioall Sci

View full text Add to dashboard Cite

Aim:To develop a simple, accurate, sensitive, rapid and precise method for the determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form.Material and Methods:The method employs wavelength detection and determination of galantamine hydrobromide at excitation wavelength 282 nm and emission wavelength 607 nm in a solution of simple distilled water.Result and Conclusion:The method was found to be linear in the range of 2–14 μg/ml having r2 = 0.9999. The mean accuracy was found to be 98.12% to 99.67%. The intraday and interday precision was found to be 0.18–0.35% and 0.13–0.46%, respectively. The limit of detection was found to be 0.29 μg/ml. The limit of quantification was found to be 0.89 μg/ml. The method was successfully applied for the determination of galantamine hydrobromide in bulk drug as well as pharmaceutical dosage form.

show abstract

“…Though determination of duloxetine hydrochloride by spectrofluorimetric method [9,10] has been reported but there is no UV-visible spectrophotometric method for determination of duloxetine, which motivates us to develop and carry out this research work. This present research paper was found to be simple, precise, and accurate and validated as per ICH guidelines and rapid for the estimation of duloxetine in pure form.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Uv-Visible Spectrophotometric Method for Determination of Duloxetine

Samal¹,

Prusty²

2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: The aim of the present work was to develop and validate a simple UV spectroscopic method for the determination of duloxetine, which is a thiophene derivative and a selective neurotransmitter reuptake inhibitor for serotonin, norepinephrine, and to lesser degree dopamine. Methods: The UV Spectrophotometric analysis was performed using Shimadzu UV-1800 and Shimadzu UV-1700 spectrophotometer by using solvent system acetonitrile and water in the ratio of 8:2. Detection was performed at a wavelength of 290 nm. Method validation was carried out according to ICH Q2R1 guidelines by taking the parameters linearity, accuracy, precision, ruggedness, and robustness, LOD and LOQ. Results: The UV Spectrophotometric method was found linear in the range of 10-50 μg/ml. The method was rugged and robust with % relative standard deviation less than 2. The extraction recoveries were found to be higher than 99% in all experimental conditions. Conclusion: Based upon the performance characteristics, the proposed method was found accurate, precise and rapid and suitable for the determination of Duloxetine for routine analysis.

show abstract

Spectrofluorimetric method for determination of duloxetine hydrochloride in bulk and pharmaceutical dosage forms

Cited by 17 publications

References 3 publications

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry

Development and Validation of Uv-Visible Spectrophotometric Method for Determination of Duloxetine

Contact Info

Product

Resources

About