Spectrofluorimetric Assessment of Metoclopramide Hydrochloride Using Terbium Doped in PMMA Matrix Optical Sensor

Abstract

A new, simple and accurate spectrofluorimetric method for the determination of metoclopramide hydrochloride was developed. The metoclopramide hydrochloride can remarkably enhance the luminescence intensity of the Tb(3+) ion doped in PMMA matrix at λ(ex)=360 nm in methanol at pH 6.9. The intensity of the emission band at 545 nm of Tb(3+) ion doped in PMMA matrix is increased due to the energy transfer from metoclopramide hydrochloride to Tb(3+) in the excited stated. The effect of different parameters, e.g., pH, temperature, Tb(3+) concentration, foreign ions that control the fluorescence intensity of the produced ion associate was critically investigated. The calibration curve of the emission intensity at 545 nm shows linear response of metoclopramide over a concentration range of 5 × 10(-5)-5.0 × 10(-8) M with detection limit of 8.7 × 10(-10) M. The method was used successfully for the determination of metoclopramide in pharmaceutical preparations and human serum. The average recovery of 99.48% with standard deviation of 0.32% and 96.98% with standard deviation of 0.4%, of pharmaceutical preparations and human serum respectively, were obtained which compared will with the results obtained from standard LC method of average recovery 99.04% and standard deviation of 0.6% and average recovery of 98.19% with standard deviation of 0.6% of pharmaceutical preparations and human serum, respectively.

Spectrofluorometric Determination of Alpha Fetoprotein in different serum samples of Liver Cancer by Tb-acetyl acetone complex embedded in Polymethylmethacrylate optical sensor

“…After the addition of ACAC to the Tb 3+ ion in the PMMA matrix, the characteristic peaks of the Tb 3+ ion ( 5 D 4 → 7 F 6 , 5 D 4 → 7 F 5 , and 5 D 4 →F 4 ) appeared (see curves 2 and 1 in Fig. 2) [27][28][29][30][31]. Comparing curve 4 with curves 2 and 3 in Fig.…”

Spectrofluorimetric Assessment of Hydrochlorothiazide Using Optical Sensor Nano-Composite Terbium Ion Doped in Sol-Gel Matrix

“…6 H 2 O in sol-gel matrix was studied under the conditions established above. The results show that there is no quenching in the energy of Tb 3+ -(HCT) in solgel matrix in the presence of acetonitrile [30][31][32][33][39][40][41][42].…”

A highly luminescent complexes of Eu(III) and Tb(III) with norfloxacin and gatifloxacin doped in sol–gel matrix: A comparable approach of using silica doped Tb(III) and Eu(III) as optical sensor

“…Also, the luminescence intensities for the complex in aprotic solvent like acetonitrile and DMF are stronger than in protic solvent like water and ethanol. This could be attributed to the efficient quenching of the excited state of the Eu 3 þ and Tb 3 þ by interaction with high-energy vibration oscillators like O-H groups [35].…”