Spectrofluorimetric Assessment of Hydrochlorothiazide Using Optical Sensor Nano-Composite Terbium Ion Doped in Sol-Gel Matrix

Abstract

A new, simple, sensitive and selective spectrofluorimetric method for the determination of Hydrochlorothiazide was developed in acetonitrile at pH 6.2. The Hydrochlorothiazide can remarkably enhance the luminescence intensity of the Tb(3+) ion doped in sol-gel matrix at λ(ex) = 370 nm. The intensity of the emission band of Tb(3+) ion doped in sol-gel matrix was increased due to the energy transfer from the triplet excited state of Hydrochlorothiazide to ((5)D(4)) excited energy state of Tb(3) ion. The enhancement of the emission band of Tb(3+) ion doped in sol-gel matrix at ((5)D(4)→(7)F(5)) 545 nm was directly proportion to the concentration of Hydrochlorothiazide with a dynamic ranges of 5.0 × 10(-10)-5.0 × 10(-6) mol L(-1) and detection limit of 2.2 × 10(-11) mol L(-1).

Towards the development of solid-state platform optical sensors: aggregation of gold nanoparticles on polyurethane foam

“…The inability of detection in unclear or colored solutions and instability of some AuNPs in aqueous phase limit time of life of such sensors, whereas changeability of AuNP aggregates makes reevaluation of the analysis difficult. These problems could be overcome using solid-phase sensors [16][17][18][19][20][21][22][23][24].…”

“…Several nanoparticle-based colorimetric approaches on a solid-state platform have been developed [16][17][18][19][20][21][22]. Most of them are based on using nanoparticles firmly attached to a solid matrix or incorporated into a flexible brush-like surface layer.…”

A Rapid DMeyer-CWT Method Application to the Spectrophotometric Data for the Quantification of Losartan Potassium and Hydrochlorothiazide in a Binary Mixture

“…The aim of this study is to propose a new signal processing approach based on the simultaneous quantitative detection of losartan potassium (LOS) and hydrochlorothiazide (HCT) in tablets without the usage of a separation step using CWT and zero crossing methodology [15]. In pharmacological and biological investigations, several analytical techniques for the determination of LOS and HCT have been published, including spectrophotometric methods [16][17][18][19], spectrofluorometric methods [20], and chromatographic methods [21][22][23][24][25].…”

Spectrophotometric Determination of Losartan Potassium and Hydrochlorothiazide in tablets by Wavelet Transform Approach

“…In this paper, the aim is is to develop new signal processing method based on the combined use of CWT with zero crossing technique simultaneous quantitative determination of losartan potassium (LOS) and hydrochlorothiazide (HCT) in tablets without the use of a separation step. Several analytical methods for the analysis of LOS and HCT have been reported in pharmaceutical and biological studies, including spectrophotometric methods [15][16][17][18], spectrofluorometric method [19] and chromatographic methods [20][21][22][23][24].…”