Spectrofluorimetric and micelle-enhanced spectrofluorimetric methods for determination of Felodipine and Nimodipine in pharmaceutical preparations and human plasma

Mohamed, Abdel‐Maaboud I.; Omar, Mahmoud A.; Hammad, Mohamed A.; Mohamed, Abobakr A.

doi:10.1016/j.saa.2015.05.026

Cited by 23 publications

(19 citation statements)

References 17 publications

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“…[ 19 ] This enhancement has been used to increase sensitivity and selectivity of various luminescence techniques. [ 20–22 ]…”

Section: Introductionmentioning

confidence: 99%

“…Several analytical methods have been reviewed for determination of NAP in formulations and biological matrices in analytical profile. [ 23 ] Other reported methods include spectrophotometry, [ 24–29 ] HPLC, [ 30–34 ] high performance thin layer chromatography (HPTLC), [ 29 ] spectrofluorimetry [ 3,5–39 ] and voltammetry. [ 40,41 ]…”

Section: Introductionmentioning

confidence: 99%

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Micelle‐enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets

2021

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Two simple and sensitive spectrofluorimetric methods were developed and validated for determination of diphenhydramine. The use of sodium dodecyl sulfate surfactant at pH 7 enhances the fluorescence intensity of diphenhydramine at 286 nm (method I) enabling its nanodetermination in biological samples with mean per cent recovery ± SD of 100.33 ± 1.519. Method I was validated according to ICH‐Q2R1 guidelines and was successfully applied for determination of diphenhydramine in pharmaceutical dosage form and spiked human plasma in the concentration ranges 0.1–4.0 μg/mL and 0.2–1.0 μg/mL, respectively. Method I acted as a basis for the development of a first derivative synchronous spectrofluorimetry (method II) for simultaneous analysis of diphenhydramine and naproxen using a zero‐crossing approach. Method II determines both drugs with linearity ranges of 0.05–3.0 μg/mL and 0.1–0.9 μg/mL for diphenhydramine and naproxen, respectively. The developed method was applied for the simultaneous determination of both drugs in their laboratory‐prepared mixtures containing all expected excipients. Method II determines both drugs with a mean percent recovery ± SD of 100.56 ± 0.891 and 100.20 ± 1.125 for diphenhydramine and naproxen, respectively. The method was statistically compared with a reported method using Student's t‐ and F‐ tests, and no significant differences were observed.

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“…[ 19 ] This enhancement has been used to increase sensitivity and selectivity of various luminescence techniques. [ 20–22 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Micelle‐enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets

2021

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“…On the other hand, spectrouorimetric methods have the advantages of being simple, highly sensitive and time saving technique. [12][13][14][15][16] To our knowledge, there is no reported spectrouorimetric method for determination of salmeterol xinafoate up till now. In this study, we investigate the reaction of salmeterol xinafoate that contains a basic secondary amine with NBD-Cl which has been widely used for the determination of many pharmaceuticals containing primary and secondary amino groups [17][18][19][20][21][22] in order to develop new, simple, sensitive and rapid spectrouorimetric method for determination of the studied drug in its dosage form, spiked plasma and in the presence of its degradation products.…”

Section: Introductionmentioning

confidence: 99%

Utility of 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole for development of a highly sensitive stability indicating spectrofluorimetric method for determination of salmeterol xinafoate; application to human plasma

2017

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“…This effect may be attributable to the destructive effect of these solvents on the formed micelles . Besides that, the addition of short‐chain alcohols (ethanol and methanol) to the Tween‐20 micellar system not only resulted in a reduction of the micellar size but also it produced a progressive breakdown of the surfactant aggregates at very high concentrations . Also, dimethylformamide and dimethylsulphoxide decreased the FI of LDS, as they initiated an intersystem crossing process (similar to the heavy atom effect) .…”

Section: Resultsmentioning

confidence: 96%

Micellar‐based spectrofluorimetric method for the selective determination of ledipasvir in the presence of sofosbuvir: application to dosage forms and human plasma

et al. 2019

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A fast, low-cost, sensitive, and selective spectrofluorimetric method for the determination of ledipasvir was developed and validated. The method is based on an enhancement in the native fluorescence intensity of ledipasvir by 500% of its original value by the formation of hydrogen bonds between the cited drug and Tween-20 in the micellar system (pH = 5.0). All fluorescence measurements were carried out at 425 nm and 340 nm for emission and excitation wavelengths, respectively. A linear relationship between the concentration of ledipasvir and the observed fluorescence intensity was achieved in the range of 0.1-2.0 μg ml −1 with 0.028, 0.084 μg ml −1 , for detection and quantitation limits, respectively. The acquired selectivity and sensitivity using the proposed method facilitate the analysis of ledipasvir in spiked human plasma with sufficient percentage recovery (95.36-99.30%). The proposed method was developed and validated according to International Council for Harmonisation (ICH) guidelines. Moreover, the cited drug was successfully determined in its pharmaceutical dosage form using the proposed method. In addition, the validity of the proposed results was statistically confirmed using Student's t-test, variance ratio F-test, and interval hypothesis test. K E Y W O R D Shuman plasma, ledipasvir, pharmaceutical tablets, sofosbuvir, spectrofluorimetric, Tween-20

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Spectrofluorimetric and micelle-enhanced spectrofluorimetric methods for determination of Felodipine and Nimodipine in pharmaceutical preparations and human plasma

Cited by 23 publications

References 17 publications

Micelle‐enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets

Micelle‐enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets

Utility of 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole for development of a highly sensitive stability indicating spectrofluorimetric method for determination of salmeterol xinafoate; application to human plasma

Micellar‐based spectrofluorimetric method for the selective determination of ledipasvir in the presence of sofosbuvir: application to dosage forms and human plasma

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