Spectral Transmittance of Intraocular Lenses under Natural and Artificial Illumination

Artigas, José María Gatell; Felipe, Adelina; Navea, Amparo; Artigas, Cristina; García-Domene, Mari Carmen

doi:10.1016/j.ophtha.2010.06.023

Cited by 40 publications

(34 citation statements)

References 26 publications

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“…Proponents argue that it might provide, for example, extra protection against age-related retinal disease and improves chromatic aberration. 28 Opponents point out that positive effects are unproven that 'blue blockers' cause loss in scotopic vision and might have adverse effects on the circadian physiology by reducing the input to nonvisual photoreception. 29 A meta-analysis showed no advantages for visual performance.…”

Section: Eyementioning

confidence: 99%

Light damage to the retina: an historical approach

Norren

Vos²

2015

Eye

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A brief review of retinal light damage is presented. Thermal damage requires a local rise in temperature of at least 10°C, causing an instant denaturation of proteins. The primary absorber is melanin. Photochemical damage occurs at body temperature and involves cellular damage by reactive forms of oxygen. The photosensitizers are photoproducts of the visual pigments. First indications that non-thermal damage might exist, in particular in the case of eclipse blindness, was presented by Vos in 1962. Attribution thereof to photochemical action was presented in 1966 by Noell et al who also measured the first action spectrum, in rat. It turned out to be identical to the absorption spectrum of rhodopsin. However, in 1976 and 1982 Ham et al found a quite different spectrum in monkeys, peaking at short wavelengths. The latter spectrum, but not the former, was confirmed since in numerous publications with animal models including rat. In ophthalmological practice a 'sunburn' was at first the only complaint caused by light damage. To avoid this, patients with dilated pupils should always be advised to wear sunglasses. Since the invention of the laser accidents have been reported, the most recent development is youth playfully pointing a strong laser pen in their eyes with marked consequences. The operation microscope and endoilluminators should always be used as brief as possible to avoid photochemical damage. Arguments for implant lenses that block not only the UV but also part of the visible spectrum seem too weak to justify extra costs.

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Section: Eyementioning

confidence: 99%

Light damage to the retina: an historical approach

Norren

Vos²

2015

Eye

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“…3). This Figure shows that the IOL incorporates a perfect cut-off filter [18], which totally filters out ultraviolet radiation, only a slight uniform decrease (approximately 3%) in the transmission in the visible spectrum when the IOL is drug-loaded can be observed. When the IOL releases the drug this small decrease is practically recovered.…”

Section: Discussionmentioning

confidence: 95%

“…The integrating sphere is used, which means that all radiation that passes through the IOL, both direct and scattered, is collected by the detector. The air was taken as a reference to measure transmittance [18].…”

Section: Spectral Transmission Measurementsmentioning

confidence: 99%

Intra-ocular lens optical changes resulting from the loading of dexamethasone

Artigas

García-Domene

Navea

et al. 2017

Biomed. Opt. Express

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Abstract:To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)-silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties. Br.

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“…In fact, the integrating sphere mode [14][15][16] is always used for ascertaining not only the shape of the spectral transmission curve, but also the total amount of light that passes through the IOL. The integrating sphere mode is also used for human 17 and pig 18 crystalline lenses.…”

Section: Discussionmentioning

confidence: 99%

Determination of scattering in intraocular lenses by spectrophotometric measurements

et al. 2014

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Abstract. This study presents a method for measuring scattering in explanted intraocular lenses (IOLs). Currently, determining scattering in IOLs is usually performed by Scheimpflug cameras and the results are expressed in the units used by this apparatus. The method we propose uses a spectrophotometer and this makes it possible to measure the total transmission of the IOL by using an integrating sphere; the direct transmission is determined by the double-beam mode. The difference between these two transmissions gives a value of the scattering in percentage values of light lost. In addition, by obtaining the spectral transmission curve, information about the most scattered wavelengths is also obtained. The IOL power introduces errors when directly measured, particularly with high powers. This problem can be overcome if a tailor-made cuvette is used that shortens the distance between the IOL and the condensing lens of the spectrophotometer when the IOL powers are below 24 diopters. We checked the effectiveness of this method by measuring the scattering of three explanted IOLs from cornea donors. This method, however, does not make it possible to ascertain whether the scattering measured is caused by surface light scattering or internal light scattering. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Spectral Transmittance of Intraocular Lenses under Natural and Artificial Illumination

Cited by 40 publications

References 26 publications

Light damage to the retina: an historical approach

Light damage to the retina: an historical approach

Intra-ocular lens optical changes resulting from the loading of dexamethasone

Determination of scattering in intraocular lenses by spectrophotometric measurements

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