Spectral optical coherence tomography findings in patients with ocular toxoplasmosis and active satellite lesions (MINAS Report 1)

Oréfice, Juliana Lambert; Costa, Rogério A.; Scott, Ingrid U.; Calucci, Daniela; Oréfice, Fernando

doi:10.1111/j.1755-3768.2012.02531.x

Cited by 41 publications

(22 citation statements)

References 27 publications

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“…Localized choroidal thickening has already been described in patients with ocular toxoplasmosis or choroidal tumors [8,9]; however, different from the choroidal bulging observed in this series of patients with VKH disease, an associated retinal or choroidal lesion was invariably observed in these scenarios on clinical exam (i.e., fundoscopy).…”

Section: Discussioncontrasting

confidence: 65%

Choroidal bulging in patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage

Sakata

Silva

Hirata

et al. 2014

J OPHTH INFLAMM INFECT

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BackgroundDetection of choroidal inflammation in Vogt-Koyanagi-Harada (VKH) disease is still a challenge. Progression to sunset glow fundus has been observed despite apparent good clinical control of inflammation. Indocyanine green angiography (ICGA) permits choroid inflammation detection, though it is invasive, time consuming, and costly. The purpose of the present study is to report a sign indicative of probable inflammation on enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT): a localized increase in choroidal thickness with bulging of the outer retina (‘choroidal bulging’) in patients with VKH disease in the non-acute uveitic stage.FindingsThis is a retrospective observational study. The choroidal bulging was a particular finding observed in four eyes of three patients with VKH disease in the non-acute uveitic stage (median disease duration 55.3 ± 40.3 months, range 10 to 108). This study is part of an ongoing longitudinal study in patients with VKH disease carried out in the Uveitis Service, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. In all eyes, the choroidal bulging was identified in the presence of anterior chamber cells and/or on fundus angiographic (fluorescein and indocyanine green) findings, indicative of disease activity. Changes in the thickness of the choroidal bulging accompanied the variation in the clinical and angiographic signs of inflammation.ConclusionThe choroidal bulging is a particular finding detected on EDI-OCT that may indicate ongoing inflammation in the posterior segment of the eye. This EDI-OCT feature may assist in the treatment-monitoring of patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage.

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Section: Discussioncontrasting

confidence: 65%

Choroidal bulging in patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage

Sakata

Silva

Hirata

et al. 2014

J OPHTH INFLAMM INFECT

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“…In addition, thickening of the posterior hyaloid, hyperreflective signals, and spherical hyperreflective depositions in vitreous have been reported [8]. One-fifth of the patients were reported to have subretinal fluids at the lesion site [6,8]. We could demonstrate the active lesion in three of eight patients and see thickening of the retina at the lesion site, increased reflectivity of inner retinal layers, and posterior shadowing in all.…”

Section: Discussionmentioning

confidence: 56%

“…It has been reported that the retina was thickened at the lesion site, with an increased reflectivity of inner retinal layers and posterior shadowing [7]. In addition, thickening of the posterior hyaloid, hyperreflective signals, and spherical hyperreflective depositions in vitreous have been reported [8]. One-fifth of the patients were reported to have subretinal fluids at the lesion site [6,8].…”

Section: Discussionmentioning

confidence: 99%

Causes of visual impairment in patients with ocular toxoplasmosis

Şahinoğlu-Keşkek

Ünal

Cevher

et al. 2017

J Infect Dev Ctries

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Introduction: The aim of this study was to report the causes of visual impairment in patients with the classic clinical presentation of ocular toxoplasmosis (OT). Methodology: Eight patients with OT underwent standardized ophthalmologic examination and fundus imaging. Macula and the lesions that could be visualized were evaluated by spectral domain optical coherence tomography (SOCT) at presentation. The scan acquisition protocols for SOCT included a radial line scan through the retinochoroiditis lesion, radial line macular scan, and horizontal volume scans at the macula. Results: The mean age of the five (62.5%) women and three (37.5%) men was 25.7±7.6 years. The mean logMAR ETDRS best-corrected visual acuity was 0.45 (Snellen equivalent, 20/50). SOCT findings of macula were normal in seven patients, and one patient had decreased retinal thickness from a healed chorioretinitis at the fovea. Of eight patients, two had 3+ vitreous haze, four had 2+ vitreous haze, and two had 1+ vitreous haze at presentation. OCT scans revealed vitreous hyperreflective dots in all patients with different densities in different radial scans. Hyperreflective dots were denser in macular scans of eyes in which the active lesion was closer to the fovea. Conclusions: In this study, visual impairment in majority of the patients was found to be related to vitreous cells and flare. Dense vitritis on macula scans and visual impairment were seen in the patients who had an active lesion closer to the fovea. SOCT may provide objective data of the cellular load of the eyes with posterior segment inflammation.

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“…Spectral-domain optical coherence tomography (SD-OCT) imaging is an important diagnostic tool to identify the morphological features of the vitreoretinal changes in ocular toxoplasmosis [39,40,41]. The stage of the disease is determinant for the SD-OCT findings of chorioretinal lesions.…”

Section: Clinical Featuresmentioning

confidence: 99%

Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis

Özgönül

Besirli²

2016

Ophthalmic Res

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Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised patients, may create diagnostic challenges and lead to misdiagnosis and inappropriate treatment. Molecular biology techniques to diagnose ocular toxoplasmosis have been available for many years and are now accessible as standard laboratory tests in many countries. Aqueous humor or vitreous evaluation to detect parasite DNA by polymerase chain reaction or specific antibody may provide definitive evidence for rapid diagnosis. Oral pyrimethamine and sulfadiazine plus systemic corticosteroids are an effective therapy for ocular toxoplasmosis. Recent data supports the use of other treatment approaches, including intravitreal antibiotics. The aim of the present review is to discuss briefly the new diagnostic tools and treatment options for ocular toxoplasmosis.

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Spectral optical coherence tomography findings in patients with ocular toxoplasmosis and active satellite lesions (MINAS Report 1)

Cited by 41 publications

References 27 publications

Choroidal bulging in patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage

Choroidal bulging in patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage

Causes of visual impairment in patients with ocular toxoplasmosis

Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis

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