Spectral monitoring of biologically active solar UVB radiation using an in vitro model of vitamin D synthesis

Terenetskaya, I. P.

doi:10.1016/s0039-9140(00)00459-8

Cited by 30 publications

(30 citation statements)

References 18 publications

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“…In view of significant difference between the CIE erythema and 'Vitamin D' action spectra [11,12], polysulphone film is incapable to adequate evaluation of the vitamin D synthetic capacity of sunlight and/or an artificial UV source. Since vitamin D synthesis is originated from the UVB photon absorption by provitamin D molecule, obviously, a UV transparent film impregnated with provitamin D molecules is the most appropriate material for the 'antirachitic' UV dosimetry.…”

Section: Discussionmentioning

confidence: 99%

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Provitamin D Doped Silica and Polymeric Films: New Materials for UV Biosensor

Orlova¹,

Terenetskaya²,

Eremenko³

et al. 2010

MSA

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Section: Discussionmentioning

confidence: 99%

“…Being extension of our previous studies on the reaction medium effect on provitamin D photochemistry [7][8][9][10], this work is also directed on elaboration of new UV sensitive materials, in particular, as UV biosensors for direct monitoring of the vitamin D synthetic capacity of solar/artificial UV radiation [11,12].…”

Section: Introductionmentioning

confidence: 99%

Provitamin D Doped Silica and Polymeric Films: New Materials for UV Biosensor

Orlova¹,

Terenetskaya²,

Eremenko³

et al. 2010

MSA

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“…A significant step towards the widespread practical use of the in vitro model for on-site measurements was the development of original spectrophotometric analysis of the photoisomer mixture formed under UV irradiation of 7-Dehydrocholesterol [7,8].…”

Section: Methodsmentioning

confidence: 99%

“…Before the beginning of an irradiation and after the certain exposures, the absorption spectrum of the solution is registered by a spectrophotometer within a range of 230-330 nm with a 1 nm step. Then for concentration analysis the recorded spectra are processed by computer using original software [8], and the concentration of accumulated previtamin D, which determines 'antirachitic' UV dose, is obtained.…”

Section: Measurement Of Previtamin D Concentration Using Spectrophotomentioning

confidence: 99%

Metrology of the vitamin-D-synthetic activity of UV lamps

Terenetskaya

Orlova

2017

18th International Congress of Metrology

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Abstract. Ultraviolet lamps are widely used in phototherapy, and positive health effect of UV irradiation is associated with the synthesis of vitamin D in human skin. Nevertheless, to avoid harmful effects of UV radiation a variety of commonly used broadband UV detectors have an output in erythema units. Therefore the measurement of the vitamin-D-synthetic capacity is a missing link in the metrology of UV lamps that are used for medical and/or cosmetic purposes. This paper presents original UV measuring device based on the same photoreaction in vitro by which vitamin D is synthesized in human skin via photo-and thermo-induced conversions of 7-Dehydrocholesterol (provitamin D 3 ). Thus the targets for UV photons are provitamin D molecules embedded in specially designed UV transparent and stable matrix mimicking biological samples. Three operation modes of varying complexity are developed to follow the photoreaction course in real time.

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“…Excessive solar UV radiation exposure led to the premature deaths of approximately 60 000 people in the year 2000 . It is well known that exposure to small amounts of UV radiation are beneficial for the human body and important in the production of vitamin D 3 , whereas excessive exposure to sunlight is known to cause skin cancer, immune suppression, DNA damage, erythema and sun-related eye disorders (Baron et al, 2003;Glerup et al, 2000;Terenetskaya, 2000;Sliney, 2004;Setlow et al, 1993). Approximately 90-95% of our vitamin D 3 requirement comes from exposure to the sun (Holick, 2004;Holick, 1998).…”

Section: Introductionmentioning

confidence: 99%

Utilising shade to optimize UV exposure for vitamin D

Turnbull

Parisi

2008

Atmos. Chem. Phys.

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Abstract. Numerous studies have stated that humans need to utilise full sun radiation, at certain times of the day, to assist the body in synthesising the required levels of vitamin D 3 . The time needed to be spent in the full sun depends on a number of factors, for example, age, skin type, latitude, solar zenith angle. Current Australian guidelines suggest exposure to approximately 1/6 to 1/3 of a minimum erythemal dose (MED), depending on age, would be appropriate to provide adequate vitamin D 3 levels. The aim of the study was to determine the exposure times to diffuse solar UV to receive exposures of 1/6 and 1/3 MED for a changing solar zenith angle in order to assess the possible role that diffuse UV (scattered radiation) may play in vitamin D 3 effective UV exposures (UV D 3 ). Diffuse and global erythemal UV measurements were conducted at five minute intervals over a twelve month period for a solar zenith angle range of 4 • to 80 • at a latitude of 27.6 • S. For a diffuse UV exposure of 1/3 MED, solar zenith angles smaller than approximately 50 • can be utilised for exposure times of less than 10 min. Spectral measurements showed that, for a solar zenith angle of 40 • , the UVA (315-400 nm) in the diffuse component of the solar UV is reduced by approximately 62% compared to the UVA in the global UV, whereas UV D 3 wavelengths are only reduced by approximately 43%. At certain latitudes, diffuse UV under shade may play an important role in providing the human body with adequate levels of UV D 3 (290-315 nm) radiation without experiencing the high levels of UVA observed in full sun.

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Spectral monitoring of biologically active solar UVB radiation using an in vitro model of vitamin D synthesis

Cited by 30 publications

References 18 publications

Provitamin D Doped Silica and Polymeric Films: New Materials for UV Biosensor

Provitamin D Doped Silica and Polymeric Films: New Materials for UV Biosensor

Metrology of the vitamin-D-synthetic activity of UV lamps

Utilising shade to optimize UV exposure for vitamin D

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