Provitamin D Doped Silica and Polymeric Films: New Materials for UV Biosensor

Orlova, Tetiana; Terenetskaya, I. P.; Eremenko, A. M.; Surovtseva, N. I.

doi:10.4236/msa.2010.15039

Cited by 1 publication

(2 citation statements)

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“…Similar transformations were detected upon UV irradiation with both lamps for the hydrogel films with incorporated 7-DHC (provitamin D3). It is significant that unlike previous data on provitamin D doped polymer and porous silica films [5], the absorption spectra of both provitamins in hydrogel matrices were almost identical to the spectra in ethanol solution. With the help of specifically developed software [12], the above-mentioned fact allowed processing the spectra for concentration analysis based on the known photoisomer individual spectra in the solution [15].…”

Section: Resultscontrasting

confidence: 88%

“…Influence of a reaction medium on the photochemistry of biologic molecules is of great current interest. Photoisomerization of provitamin D, in particular, as the initial step of natural synthesis of vitamin D upon sunlight, has been studied in various media [1][2][3][4][5]. For the most part, interaction of provitamin D molecules with microenvironment affects both the absorption spectrum and the photoconversions.…”

Section: Introductionmentioning

confidence: 99%

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Photoisomerization of Provitamin D in Hydrogel Matrix

Terenetskaya¹,

Samchenko²,

Orlova³

et al. 2013

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Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)-and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D 3 (7-dehydrocholesterol) and D 2 (ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active 'antirachitic' UV radiation.

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Section: Resultscontrasting

confidence: 88%